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Intranasal insulin improves cognitive function in patients with type 2 diabetes
Date:11/13/2013

ents with diabetes. Fifteen patients with diabetes and 14 healthy older adults, average age 62, were administered a single 40-unit dose of insulin or saline in a randomized order on two subsequent days. Measurements of brain function were then made using regional perfusion and vasodilatation with 3 Tesla MRI and neuropsychological evaluation of learning and memory.

"We observed in both the healthy subjects and the patients with diabetes that there was an improvement in both verbal learning and visual-spatial learning and memory after they received the insulin," explains Novak. Through imaging tests, the investigators also learned that these improvements were dependent on the brain's vascular function.

"Our findings provide preliminary evidence that intranasal insulin administration appears safe in older adults, and does not lead to low sugar levels," says Novak. "Intranasal insulin may potentially improve learning and memory in older adults with and without diabetes, through vascular mechanisms. However, larger and longer duration studies are needed to determine whether intranasal insulin may provide long-term benefits for memory in older patients with diabetes."


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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

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