Navigation Links
Intranasal insulin improves cognitive function in patients with type 2 diabetes
Date:11/13/2013

BOSTON In recent years, the link between type 2 diabetes and dementia has become widely recognized. Older individuals with diabetes develop Alzheimer's disease at an earlier age, and are more likely to develop vascular dementia than people who do not have diabetes.

Now, a small proof-of-concept study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) offers promise of a new treatment for this widespread problem. Currently published on-line in the journal Diabetes Care, the study results show that a single dose of intranasal insulin can help improve cognitive function in patients with diabetes.

"We know that diabetes accelerates brain aging," explains first author Vera Novak, MD, PhD, an investigator in the Department of Neurology at BIDMC, who conducted this research as a faculty member in BIDMC's Department of Medicine. "If we consider that there are more than 45 million people with diabetes in the U.S. alone and that older adults are the fastest growing segment of the diabetes population, we realize what an extremely serious problem we're facing."

In the brain, insulin helps to regulate signaling and connections among neurons and also regulates vascular functions. Central insulin receptors are abundant and yet are mostly dependent upon insulin transport through the blood-brain barrier. Therefore, inadequate insulin delivery may affect perfusion and cortical activity in brain regions associated with high-energy demands, such as cognitive networks.

"Previous studies had suggested that augmenting cerebral insulin may enhance cognitive function," says Novak, an Associate Professor of Neurology at Harvard Medical School. Intranasal administration delivers insulin directly to the brain, bypassing the blood-brain barrier and reaching receptors in multiple brain regions within minutes after administration.

In this pilot study, the authors tested whether similar effects would be observed in patients with diabetes. Fifteen patients with diabetes and 14 healthy older adults, average age 62, were administered a single 40-unit dose of insulin or saline in a randomized order on two subsequent days. Measurements of brain function were then made using regional perfusion and vasodilatation with 3 Tesla MRI and neuropsychological evaluation of learning and memory.

"We observed in both the healthy subjects and the patients with diabetes that there was an improvement in both verbal learning and visual-spatial learning and memory after they received the insulin," explains Novak. Through imaging tests, the investigators also learned that these improvements were dependent on the brain's vascular function.

"Our findings provide preliminary evidence that intranasal insulin administration appears safe in older adults, and does not lead to low sugar levels," says Novak. "Intranasal insulin may potentially improve learning and memory in older adults with and without diabetes, through vascular mechanisms. However, larger and longer duration studies are needed to determine whether intranasal insulin may provide long-term benefits for memory in older patients with diabetes."


'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Related medicine news :

1. Importance of Managing Insulin Resistance Discussed in New Video By Health Nutrition News
2. 4 Tips to Increase Insulin Sensitivity and Fat Loss published By Health News Wires
3. Leptin May End Diabetic’s Need For Insulin Injections
4. Longest and largest study of insulin pumps to treat type 1 diabetes in children shows they control blood sugar more effectively and with fewer complications than injections
5. Effects of Insulin Resistance and How to Increase Insulin Sensitivity Published in New Video by Health News Wire
6. A reduction in BMI improves insulin sensitivity in obese teens
7. Insulin Pump Therapy Provides Better Glycemic Control Among Type 1 Diabetics, According to Kantar Health Research
8. Tiny RNA molecule may have role in polycystic ovary syndrome, insulin resistance
9. Case Western Reserve receives Helmsley Trust grant to develop new glucose-sensitive insulin
10. Taking insulin for type 2 diabetes could expose patients to greater risk of health complications
11. Binge drinking increases risk of Type 2 diabetes by causing insulin resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice ... X users can now reveal the media of their split screens with growing ...
(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... people are unfamiliar with. The article goes on to state that individuals are now ... of these less common operations such as calf and cheek reduction. The Los Angeles ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
Breaking Medicine Technology: