Navigation Links
Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
Date:10/17/2007

Portal venous tumor thrombus (PVTT) is a crucial factor that can worsen the prognosis of patients with hepatocellular carcinoma (HCC). It often leads to extensive spreading of the tumor throughout the liver, and can increase portal venous blood pressure, resulting in the fatal rupture of esophageal varices, and can decrease portal flow which causes ascites, jaundice, hepatic encephalopathy, and liver failure. However, there is no effective useful therapy for HCC combined with PVTT. Therefore, there is an urgent need for new and active drugs and combination chemotherapy of advanced HCC.

A total of 10 consecutive patients with Stage IVA HCC accompanied by PVTT were studied prospectively to examine the efficacy of treatment by intra-arterial infusion of a chemotherapeutic agents consisting of etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil by Ishikawa, et al.

The median survival time after the therapy was 457.2 days; the 1-year survival rate was 70 %. Adverse reactions were tolerable.

Although the prognosis of most patients with HCC by PVTT is poor, our combination chemotherapy may induce long-term survival and is an effective treatment and produced anti-tumor activity with tolerable adverse effects in patients for advanced HCC accompanied by PVTT.

Intra-arterial combination chemotherapy is useful and inducing long-term survival for advanced HCC accompanied by PVTT. Further prospective randomized clinical trials of chemotherapy for HCC with PVTT are needed.


'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
0086-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Smoking and Breast Cancer - A Deadly Combination
3. The bad combination
4. Drug Combinations May Boost Stroke Risk
5. Combination therapy to treat breast cancer
6. Combination regime may work against prostate cancer
7. New Drug Combination Found To Improve Memory in Alzheimer’s Patient
8. A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
9. Combination Therapy Effective In Improving Lung Cancer Survival
10. Combination Therapy Found To Improves Stroke Recovery
11. Combination Therapy Found To Be More Effective In Treating Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... Tuesday, May 24, Women's Excellence ... practice enhanced with Young Living Essential Oils, taught by Patti Dolan, RYT, a ... Orion location. Yoga Flow is 6:30pm - 7:15pm followed by a small intro to ...
(Date:5/24/2016)... ... ... launched the #perioddrama campaign to mark Menstrual Hygiene Day on May 28 and raise ... do not have access to a toilet, even when they’re on their periods. , WaterAid ... (sometimes hilarious) results help shine a light on the awkwardness that women face while menstruating, ...
(Date:5/24/2016)... ... May 24, 2016 , ... Local ... Republic on September 21, 2016. Dr. Gerard, who holds a Doctorate of Chiropractic ... not-for-profit organization promoting health and wellness in Third World countries where resources are ...
(Date:5/24/2016)... ... ... The Dream Builders Project, a 501(c)3 nonprofit organization based in Los Angeles, ... Mexico on Saturday, May 21st. The volunteers took the children out for the day ... 15 volunteers traveled from Los Angeles to Tijuana, Mexico for the day in the ...
(Date:5/24/2016)... , ... May 24, 2016 , ... The old expression ... the problem. A common injury that’s often misunderstood, whiplash should be swiftly diagnosed and ... Harvard-trained, orthopedic spine surgeon at Atlantic Spine Center . , So named ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... May 23, 2016 Global Paclitaxel ... pages, profiles 12 companies and the Paclitaxel analysis in ... on the industry and its players. This ... in nature, details the current state of the industry ... definitions, classifications, applications and industry chain structure. The Paclitaxel ...
(Date:5/23/2016)... May 23, 2016 The World Health Organization (WHO) ... device to include adolescents aged 13 years, and above. Effective ... offered for adult and adolescent males in the 14 priority ... PrePex was the first male circumcision device to receive WHO ... Eddy Horowitz said: " The expanded ...
(Date:5/23/2016)... May 23, 2016   Purdue Pharma L.P. ... an agreement with Egalet Corporation and Acura Pharmaceuticals, ... part of the agreement the companies will exchange ... all three companies to develop and sell several ... "This agreement reflects the commitment of Purdue Pharma ...
Breaking Medicine Technology: