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Interventional radiologists: Tough on liver cancer, kind to patients
Date:10/19/2011

Salem.

In a related report, "Consolidation of Hepatic Arterial Inflow by Embolization of Variant Hepatic Arteries in Preparation for Yttrium-90 Radioembolization," the same team was able to make treatment simpler and safer by blocking extra (variant) arteries that almost half of normal people have and utilizing collateral (detour) vessels inside the liver to assist in microsphere delivery. "After blocking these variant arteries, we were able to treat nearly 100 percent of tumors through the main hepatic arterytaking advantage of the networks of blood vessels within the liver," reported Sze.

"By embolizing small, less important vessels to the tumors, one main arterial channel was created that could treat the entire area in a technically simple and practical way," Salem explained. He also noted that these principles may be applicable to other embolization procedures, such as drug-eluting bead chemoembolization using microspheres that have been impregnated with a chemotherapy agent rather than radioactivity. "Based on this research, more people who are not good candidates for surgery will benefit in several ways," he explained.

"Whenever we can administer chemotherapy directly to a tumor, we limit the drug's entrance into the patient's bloodstream and thus lessen the spread throughout the body and the associated consequences and side effects. This method of delivering chemotherapy provides an additional advantage by releasing the drug slowly, destroying the tumor over a greater period of time. The new techniques applied to radioembolization may also be applied to chemoembolization," said Salem.

In "Toxicities Following Radioembolization With Yttrium-90 SIR-Spheres: Incidence and Contributing Risk Factors at a Single Center," Thomas Jefferson University researchers examined the results of liver function tests from 29-571 days following treatment in 81 patients who received 122 Y-90 infusions to treat primary or metastatic liver tum
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Contact: Ellen Acconcia
eacconcia@sirweb.org
703-460-5582
Society of Interventional Radiology
Source:Eurekalert

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