Navigation Links
Interspecies transplant works in first step for new diabetes therapy
Date:7/12/2013

ach seem insurmountable until now.

In the new study, scientists persuaded the immune systems of mice to recognize rat islets as their own and not reject them. Notably, the method did not require the long-term use of drugs to suppress the immune system, which have serious side effects. The islets lived and produced insulin in the mice for at least 300 days, which is as long as scientists followed the mice.

While the barrier from rats to mice is probably lower than from pigs to humans, the study showed interspecies islet transplants are possible and without immunosuppressive drugs, Luo said.

In the study, the rat splenocytes, a type of white blood cell located in the spleen, were removed and treated with a chemical that caused their deaths. Next, the dead splenocytes were injected into the mice. The cells entered the spleen and liver and were mopped up by scavenger cells. The scavengers processed the splenocytes and presented fragments of them on their cell surface, triggering a reaction that told the T cells to accept the subsequently transplanted rat islets and not attack them.

But rejection was still a threat. A unique challenge of an interspecies transplant is controlling the B cells, immune cells that are major producers of antibodies. Initially, when scientists transplanted the rat islets into the mice, the mouse immune system started producing antibodies against the rat cells causing rejection.

To solve the problem, Luo realized she needed to kill off the B-cells at the same time she injected the donor islets into the mice. Thus, she gave the mice B-cell depleting antibodies -- already used in a clinical setting in human transplants. When the B-cells naturally returned after the transplant, they no longer attacked the rat islets.

"With this method, 100 percent of the islets survived indefinitely," Luo said. "Now we're trying to figure out why the B-cells are different when they come back."


'/>"/>
Contact: Erin White
ewhite@northwestern.edu
847-491-4888
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Injecting iron supplement lets Stanford scientists track transplanted stem cells
2. Urine biomarker test can diagnose as well as predict rejection of transplanted kidneys
3. Acid reflux surgery could help prevent rejection in lung transplant patients
4. Hair Transplant Clinics the Latest Addition to myMEDholiday.com’s Growing Specialists Directory
5. Major hurdle cleared to diabetes transplants
6. Transplant patient outcomes after trauma better than expected
7. Split liver transplants for young children proven to be as safe as whole organ transplantation
8. National review: Non-adherence among teenage heart transplant recipients is widespread, often fatal
9. Study suggests new source of kidneys for transplant
10. HIV No Barrier to Getting Liver Transplant, Study Finds
11. Robotic transplant an option for obese kidney patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 2014 Coral Gables is preparing to welcome ... Troopers, with its new clinic location set to open in ... hassle out of dealing with this common childhood parasite by ... two salon clinic locations in South Florida, or in the ... decision to expand developed naturally out of the demand for ...
(Date:12/22/2014)... New York (PRWEB) December 22, 2014 The ... a staple of the season. Many may be thinking about ... a span of a few weeks. Health Republic Insurance of ... of Registered Dietitian, Andrea Chernus, to provide some smart ideas ... and stay healthy. , 1)    Avoid arriving at a holiday gathering ...
(Date:12/22/2014)... Shanghai, China (PRWEB) December 22, 2014 ... for MabThera (rituximab) for the treatment of non-Hodgkin’s lymphoma ... Health , a leading global healthcare consulting firm. MabThera ... B-cell lymphoma (DLBCL), the most common form of NHL. ... Market Access and Barriers,” the incidence of NHL in ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Only weeks ... southern and mid-western cities to have a battery manufacturer ... TalkLocal ( http://www.talklocal.com ) is launching in Henderson ... economy. , “A strong manufacturing sector is going ... founder Gurpreet Singh explained, “and TalkLocal works with small ...
(Date:12/22/2014)... 2014 Pasadena sleep apnea ... sleep apnea. Drowsy drivers are 15 times more likely ... well-rested, and some experts believe that sleep-deprived drivers may ... drivers. Unfortunately, millions of Americans may be sleep-deprived without ... Sleep Medicine, about 18 million Americans have sleep apnea, ...
Breaking Medicine News(10 mins):Health News:Professional In-Home All-Natural Lice Removal Service Expands to Coral Gables and surrounding areas. 2Health News:Health Republic Insurance of New York Offers Five Simple Tips to Eat Healthy During the Holidays 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:TalkLocal Launches in Henderson Weeks Following New Megafactory, New Jobs Announcement 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2
... latest issue of Deutsches rzteblatt International ( ... research group presents epidemiological data. The authors surveyed ... specializing in the treatment of HIV patients in the ... to analyze the largest collection of data on the ...
... care information systems is a multibillion dollar industry. The ... to talk to each other regularly attract media comment. However ... Open Source, that could address many of these problems, because ... systems. Now new research by the University of Warwick,s ...
... Metabolomics is a post-genomic research field for analysis of ... approaches offer an analysis of metabolite level changes in ... in identifying the new diagnostic markers and therapeutic targets ... scarce. A research article to be published on ...
... an inflammatory obliterative cholangiopathy with unknown etiology, leading ... as an indispensable research tool for gene expression ... underlying BA, and allows the simultaneous analysis of ... studies have been performed to investigate the gene ...
... The best prescription for patients with venous leg ulcers is ... A five-year study led from the University of Leeds ... the healing process of leg ulceration contrary to what ... cheaper and easier to deliver, work just as well, the ...
... Reporter , MONDAY, March 7 (HealthDay News) -- Interactive ... kids, metabolisms to levels typically seen with moderate or ... the effect of six forms of so-called "exergaming" on ... (BMIs) at a youth fitness research and training center ...
Cached Medicine News:Health News:Resaerch finds open-source software is actually more secure for health care IT 2Health News:Laughter really is the best medicine (for leg ulcers) 2Health News:Video Games That Make Kids Move Burn Calories 2
(Date:12/19/2014)... Wash. , Dec. 19, 2014  Advanced ... stage development company engaged primarily in the development ... and therapeutic applications, today announced that a Life ... has been awarded for which AMIC is the ... State University (WSU) for the proposal titled "Optimized ...
(Date:12/19/2014)... , Dec. 19, 2014  Monarch America Inc. ... Kinetics Corp.) is pleased to provide this review of ... growth in 2015. "Over this past year, ... and I am extremely proud to say that Monarch ... today than it has ever been," stated Eric ...
(Date:12/19/2014)... LOS ALTOS, Calif. , Dec. 18, 2014 ... of a new generation of equipment for the ... today the release of the new Luminary™ Profiler, ... highly accurate light-based measurement in a cost-effective, portable ... to meet the specific needs of the cannabis ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 2Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 3Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2
... 2010 Decision Resources, one of the world,s leading ... finds that the methicillin-resistant S taphylococcus aureus ... in 2009 to $752 million in 2019 in the ... Japan. The Pharmacor 2010 findings from the ...
... SAN DIEGO, Nov. 10, 2010 The American Council ... the largest nonprofit fitness certification, education and training organization ... national campaign that will focus on eliminating obesity in ... motivate consumers about the critical need to regularly engage ...
Cached Medicine Technology:Driven by the Uptake of Several Emerging Agents, the MRSA Drug Market Will Increase From $631 Million in 2009 to $752 Million in 2019 2Driven by the Uptake of Several Emerging Agents, the MRSA Drug Market Will Increase From $631 Million in 2009 to $752 Million in 2019 3American Council on Exercise (ACE) Announces Nationwide Effort to Eliminate Obesity in America 2American Council on Exercise (ACE) Announces Nationwide Effort to Eliminate Obesity in America 3
Inquire...
Inquire...
... X-22 Series is up to 10 inches/ 25 cm ... 11 rotors, the Allegra X-22 Series is the space-saving ... Only 18 inches / 46 cm wide • 11 ... 3 different ways to Spin 1.5 mL & ...
... Optimal for Subcellular Fractionation, Proteins ... g (30,000 rpm) with fixed-angle ... 0.25 up to 85 mL ... C to 40° C • ...
Medicine Products: