Navigation Links
Interspecies transplant works in first step for new diabetes therapy
Date:7/12/2013

ach seem insurmountable until now.

In the new study, scientists persuaded the immune systems of mice to recognize rat islets as their own and not reject them. Notably, the method did not require the long-term use of drugs to suppress the immune system, which have serious side effects. The islets lived and produced insulin in the mice for at least 300 days, which is as long as scientists followed the mice.

While the barrier from rats to mice is probably lower than from pigs to humans, the study showed interspecies islet transplants are possible and without immunosuppressive drugs, Luo said.

In the study, the rat splenocytes, a type of white blood cell located in the spleen, were removed and treated with a chemical that caused their deaths. Next, the dead splenocytes were injected into the mice. The cells entered the spleen and liver and were mopped up by scavenger cells. The scavengers processed the splenocytes and presented fragments of them on their cell surface, triggering a reaction that told the T cells to accept the subsequently transplanted rat islets and not attack them.

But rejection was still a threat. A unique challenge of an interspecies transplant is controlling the B cells, immune cells that are major producers of antibodies. Initially, when scientists transplanted the rat islets into the mice, the mouse immune system started producing antibodies against the rat cells causing rejection.

To solve the problem, Luo realized she needed to kill off the B-cells at the same time she injected the donor islets into the mice. Thus, she gave the mice B-cell depleting antibodies -- already used in a clinical setting in human transplants. When the B-cells naturally returned after the transplant, they no longer attacked the rat islets.

"With this method, 100 percent of the islets survived indefinitely," Luo said. "Now we're trying to figure out why the B-cells are different when they come back."


'/>"/>
Contact: Erin White
ewhite@northwestern.edu
847-491-4888
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Injecting iron supplement lets Stanford scientists track transplanted stem cells
2. Urine biomarker test can diagnose as well as predict rejection of transplanted kidneys
3. Acid reflux surgery could help prevent rejection in lung transplant patients
4. Hair Transplant Clinics the Latest Addition to myMEDholiday.com’s Growing Specialists Directory
5. Major hurdle cleared to diabetes transplants
6. Transplant patient outcomes after trauma better than expected
7. Split liver transplants for young children proven to be as safe as whole organ transplantation
8. National review: Non-adherence among teenage heart transplant recipients is widespread, often fatal
9. Study suggests new source of kidneys for transplant
10. HIV No Barrier to Getting Liver Transplant, Study Finds
11. Robotic transplant an option for obese kidney patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the release of ... kids with cancer. The Chemo Duck App, available on iTunes for ... games to help children of all ages living with cancer adjust ... kids entertained, educated and at ease while waiting for clinic visits ...
(Date:1/22/2015)... is a seasoned and trusted leader who consistently delivers trendy ... have it lead the wedding dress industry into the future. ... for the global market. , “The CEO of VogueQueen is ... on continuing the goal of operational excellence and giving back ...
(Date:1/22/2015)... January 23, 2015 Angelweddingdress is a famous ... invites its customers to follow it on Facebook, Twitter, and ... Valentine’s Day gift. Angelweddingdress draws a lottery every week. , ... to Feb. 28, 2015. Click Angelweddingdress homepage for ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, ... dresses. View website of AngelWeddingDress.com to find ... wedding dresses online for a bridal party. AngelWeddingDress offers ... for them. Its maternity wedding dresses are specially designed ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3
... , , NEW YORK, Sept. ... received Orphan-Drug designation from the U.S. Food and Drug Administration (FDA) ... that it had reached an agreement with the FDA regarding a ... trial in relapsed/refractory multiple myeloma and that the study is expected ...
... , WEDNESDAY, Sept. 16 (HealthDay News) -- Supervised exercise ... pain, according to a new study. , Shockwave treatment ... a number of studies have suggested that it,s not ... women, aged 18 to 70, who,d had shoulder pain ...
... ATLANTA and LONDON, Sept. 16 ... security services, is streamlining the Payment Card Industry (PCI) ... (ITO) Self-Assessment Questionnaire processes with Predefined Assessment Programs. ... the PCI and FFIEC guidelines. An organization,s ...
... , , NORWALK, Conn., ... protection services, today announced the availability of new features in its IdentitySecure ... types of identity theft: medical identity theft. , , ... personal health records containing inaccurate information are used by health care providers ...
... , , ... and Chief Scientific Officer Dr. Michael Merzenich spoke today as the ... at General Motors Technical Center campus. Dr. Merzenich spoke about the ... to keep driving longer safely and under varied conditions. These clinically-validated ...
... , , , ... HealthLink, Inc., today announced it has changed its business name ... , "We are very excited about the introduction ... Health allows us to better represent our business as we ...
Cached Medicine News:Health News:Keryx Biopharmaceuticals Receives Orphan-Drug Designation for KRX-0401 (Perifosine) for the Treatment of Multiple Myeloma 2Health News:Keryx Biopharmaceuticals Receives Orphan-Drug Designation for KRX-0401 (Perifosine) for the Treatment of Multiple Myeloma 3Health News:Keryx Biopharmaceuticals Receives Orphan-Drug Designation for KRX-0401 (Perifosine) for the Treatment of Multiple Myeloma 4Health News:Shockwave Treatment May Not Be Best for Shoulder Pain 2Health News:SecureWorks, Inc. Streamlines the PCI AOC and FFIEC ITO Self-Assessment Questionnaire Processes with Predefined Assessment Programs and Affiliate Compliance Summary Reports 2Health News:SecureWorks, Inc. Streamlines the PCI AOC and FFIEC ITO Self-Assessment Questionnaire Processes with Predefined Assessment Programs and Affiliate Compliance Summary Reports 3Health News:Affinion Security Center Launches Benefits to Help Detect and Resolve Medical Identity Theft 2Health News:Affinion Security Center Launches Benefits to Help Detect and Resolve Medical Identity Theft 3Health News:Brain Training Keeps Older Drivers Safe Behind the Wheel 2Health News:Brain Training Keeps Older Drivers Safe Behind the Wheel 3Health News:Axion Health Inc. Issues Notification of Business Name Change 2Health News:Axion Health Inc. Issues Notification of Business Name Change 3
(Date:1/23/2015)... , Jan. 23, 2015  Mallinckrodt plc (NYSE: ... Directors has approved a share repurchase program. The open-ended ... million of Mallinckrodt plc ordinary shares. ... remain top priorities as we continue to pursue a ...
(Date:1/22/2015)...  ViewRay™, a privately held medical device company, announced today ... with ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to ... of cancer in Japan . ViewRay,s ... and only MRI-guided radiation therapy system that images and ...
(Date:1/22/2015)... - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), a ... cardiovascular disease and overall health is pleased to provide you ... its outlook for 2015 from the CEO, Mr. Eugene ... would like to take this opportunity to share with you ...
Breaking Medicine Technology:Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... Science Liaisons (MSLs) have become a key link between the ... that drive marketplace success. And the role of MSLs - ... the coming years as the device industry turns to them ... Given the expanding role of MSLs, it,s critical for organizations ...
... Watson Pharmaceuticals, Inc. (NYSE: WPI ... authorized generic version of PROMETRIUM® (progesterone, USP) Capsules ... with Abbott Laboratories. Watson began shipping the product ... the prevention of endometrial hyperplasia in non hysterectomized ...
Cached Medicine Technology:New Study Examines the Evolving Role of Medical Science Liaisons in the Medical Device Sector 2Watson Launches Generic PROMETRIUM(R) 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: