Navigation Links
Internationally known neuroblastoma expert reviews progress versus challenging childhood cancer
Date:6/14/2010

Pediatric oncologist John M. Maris, M.D., describes the current state of the science in combating neuroblastoma, the most common solid cancer of early childhood. In his article in the June 10, 2010 New England Journal of Medicine, "Recent Advances in Neuroblastoma," Maris reviews the field's latest research knowledgemuch of it based on efforts by Maris and his colleagues at The Children's Hospital of Philadelphia. Maris directs a laboratory at CHOP in collaboration with the multicenter Children's Oncology Group (COG) using tissue samples from 5,000 patientsthe world's largest sample collection for neuroblastoma.

A cancer of the sympathetic nervous system, neuroblastoma most commonly occurs as a solid tumor arising from the adrenal gland in the abdomen. Neuroblastoma remains one of the most puzzling of childhood cancersranging from cases of widespread but benign tumors in infants that spontaneously and completely disappear, to high-risk subtypes in older children that are relentlessly aggressive.

Maris is the chief of Oncology at Children's Hospital and director of the Hospital's Center for Childhood Cancer Research. Just three years ago, he wrote a review article on neuroblastoma for The Lancet. Since that time, a stream of discoveries from his lab has explored the genetic landscape of neuroblastoma. In 2008, Maris led the team that identified common DNA variations on chromosome 6, the first time researchers found the cancer's genetic origin. Later that year, Yael Mosse, M.D., collaborating at CHOP with Maris, reported that mutations in the ALK gene were the main cause of inherited neuroblastoma, and also played a role in many cases of non-inherited neuroblastoma. In 2009, Maris published two more gene studies, identifying common variants in the gene BARD1 and copy number variants on chromosome 1 that raised the risk of neuroblastoma. The latter study was the first ever to find a specific copy number variant that predisposes to a huma
'/>"/>

Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Sanford Heart Hospital Physicians Again Recognized Internationally for Innovative Techniques
2. Northern California Cancer Centers Findings on Breast Cancer and Secondhand Smoke Released Internationally by the American Association for Cancer Research
3. Reno Children With Disabilities Profit From a Little Known but Internationally Recognized Non-Profit Organization as it Quietly Crosses the $200,000.00 Mark in Service Investment Into the Reno Area
4. American Red Cross Responds Internationally and at Home to Chile Quake
5. Dr. Mahaveer Mehta, A Well Known Dermatologist from Dubai, Receives Prestigious 'Hind Rattan Award'
6. Major Imaging Initiative to Shed Light on Little Known Brain Disease
7. Physicians Coalition Asks Federal Court to Block Obama Healthcare: Doctors Claim Bill Would End Practice of Medicine as We Have Known It, Assert Presidents Actions Are Unconstitutional
8. Yoga reduces cytokine levels known to promote inflammation
9. Penn researchers find genetic link to leukemias with an unknown origin
10. Nationally Known Interventional Neuroradiologist John Pile-Spellman, M.D., Joins Neurological Surgery, P.C.
11. Chiropractic Traffic CEO Matt Prados Releases the Easiest and Fastest Free Chiropractic Marketing Method Known to Man
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Internationally known neuroblastoma expert reviews progress versus challenging childhood cancer
(Date:8/1/2015)... ... , ... The condition where veins are enlarged and gnarled is known as ... discomfort. Those who spend a lot of time on their feet and standing are ... what it can to create awareness and provide a cure in observance of Senior ...
(Date:8/1/2015)... ... 2015 , ... Brig and Lita Hart, icons of the network marketing industry ... Home mission with the HOPE Movement of EvolvHealth. In what has been a long-term ... agreed to join their missions of purpose together to change the course of the ...
(Date:8/1/2015)... ... ... Lume Wellness creators Alex, Robert, and Sam have announced update 3.0.1 to ... , The app is designed to track various metrics of wellness, including physical activity, ... health and use this information for positive behavior modification. Lume Wellness keeps track of ...
(Date:8/1/2015)... ... ... Phil Valentine – the Executive Director of Connecticut Community for Addiction Recovery (CCAR) – began ... and heading north. Since that day, Phil has hiked over 1400 miles in nine states. ... family. He visited CCAR and left an inspirational message to his staff: “You can ...
(Date:7/31/2015)... New York (PRWEB) , ... July 31, 2015 , ... ... strut their stuff, Super-Sod debuted their new type of sod called Leisure Time(TM) ... trademark application in process. , To commemorate introduction of this new type of sod, ...
Breaking Medicine News(10 mins):Health News:Northeast Houston Vein Center Warns Men about Varicose Veins 2Health News:Northeast Houston Vein Center Warns Men about Varicose Veins 3Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2
... events, from tornados, floods, fires and hurricanes, researchers at ... physiological changes associated with aging and the presence of ... or injury, even death, during a disaster. Investigators ... of 86, who were evacuated for five days due ...
... France, 21 October 2011 A pioneering educational resource, ... chronic hepatitis B, was launched today at an annual ... 26 patient advocacy groups from 14 countries and regions ... ("Patients and Professionals Acting Together for Hepatitis B") programme ...
... FRIDAY, Oct. 21 (HealthDay News) -- Elevated levels of hormones ... number of different elevated hormones rises, so does the risk, ... Women,s Hospital and Harvard Medical School in Boston examined levels ... collected from nurses up to nine years before their health ...
... a higher burden of multiple, large-joint osteoarthritis (OA), and may ... OA." African Americans were also more likely to have knee ... than Caucasians according to the findings reported today in ... College of Rheumatology (ACR). OA is the most ...
... -- The number of American women with precancerous cells ... 2000, and the increase has led to the release Thursday ... Cancer of the vulva -- the outside of the genital ... (HPV), which also causes cervical cancer. The precancerous condition -- ...
... , THURSDAY, Oct. 20 (HealthDay News) -- Most Americans consume ... needed to reduce the amount of dietary salt, according to ... of sodium consumption are associated with increased risk of high ... experts warn. In general, people aged 2 years and ...
Cached Medicine News:Health News:Elderly long-term care residents suffer cognitively during disasters 2Health News:'PATH B,' a comprehensive support program in Europe for patients with chronic hepatitis B launched 2Health News:'PATH B,' a comprehensive support program in Europe for patients with chronic hepatitis B launched 3Health News:Breast Cancer Risk May Rise With High Hormone Levels 2Health News:More African-Americans burdened by osteoarthritis in multiple large joints 2Health News:Rise in Vulvar Precancers Leads to New Guidelines 2Health News:U.S. Diet Still Has Too Much Salt, CDC Warns 2
(Date:7/30/2015)... , July 30, 2015 Eisai Inc. announced ... the United States , European Union and ... and MHLW, respectively) for eribulin, for the treatment of ... received prior chemotherapy for advanced or metastatic disease. ... from a pivotal global Phase 3 clinical trial (Study ...
(Date:7/30/2015)... 30, 2015 Future Market Insights ... "Continuous Glucose Monitoring Systems Market: Global Industry Analysis and ... the global continuous glucose monitoring systems market was valued ... to reach US$ 788.4 Mn by 2020, registering a ... 2020. Global continuous glucose monitoring systems market ...
(Date:7/30/2015)... , July 30, 2015  Medimetriks Pharmaceuticals, ... the second Phase III clinical study for Ozenoxacin, ... impetigo.  Medimetriks owns the exclusive U.S. rights to ... trial, conducted at 44 centers with an emphasis ... patients aged 2 months and older with a ...
Breaking Medicine Technology:Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 3Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 4Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 5Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 4Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 3
... 2011 Zimmer Holdings, Inc. (NYSE: ZMH ; ... the Zimmer NexGen LPS-Flex Mobile Bearing ... the United States.  The LPS-Flex Mobile Bearing knee provides a ... cruciate ligament (ACL), replicating the anatomic center of knee rotation. ...
... Reportlinker.com announces that a new market research ... Merck & Co., Inc.: PharmaVitae Profile ... IntroductionThis analysis examines the historical and forecast performance ... sector. The profile encompasses global company strategy, portfolio ...
Cached Medicine Technology:Zimmer Introduces a Move Forward in Mobile Bearing Knee Design 2Zimmer Introduces a Move Forward in Mobile Bearing Knee Design 3Reportlinker Adds Merck & Co., Inc.: PharmaVitae Profile 2
Cannulated Interference Screws...
Cannulated Interference Screws...
... new WHITESTAR Technology, which transforms traditional ultrasound ... reduces the amount of phaco energy directed ... ultrasound cutting efficiency. Surgeons have ... and efficiently to the phaco tip, in ...
... NATURE'S TEARS is an all-natural moisturizing mist ... assistance of Dr. William Mathers, from Oregon ... Mathers' study of NATURE'S TEARS (2000) and ... the mist doubled the moisture volume of ...
Medicine Products: