Navigation Links
International study suggests improved treatment alternative for lymphoid leukemia
Date:2/11/2013

cording to the National Cancer Institute, the overall survival rate for all ages of people with ALL is 66.4 percent and 90.8 percent for children under the age of 5 years.

During the onset of a disease like ALL, cancer signals among cells activate a protein called p53, which is often referred to as the "guardian of the genome." A repressor of tumor growth, p53 normally initiates a DNA repair program that is supposed to induce programmed cell death to stop or slow down tumor progression.

In the case of ALL, the researchers said the disease relies on the Gfi1 protein to get around p53's tumor repressing capabilities by essentially overriding p53. Gfi1 has an important role in the normal development of lymphoid cells. But analyses of ALL mouse models and primary human tumors showed that Gfi1 is overexpressed in the disease state.

When the researchers removed Gfi1 in established mouse lymphoid tumors, the leukemia regressed through p53-induced cell death. Next, to see if removal of Gfi1 would be effective in modeled human ALL, the research team inserted T-cell leukemia cells from human patients into mice. Inhibiting Gfi1 in this instance stopped the progression of human leukemia in the animals without any harmful effects.

The scientists are continuing their research to see if results of the current study will be translatable to human patients.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. 15th International Celiac Disease Symposium will unveil new research, dispel gluten-free myths
2. OXIS International Reports 2012 Year End Revenue Exceeds $340,000.
3. Cigars International Rolls up a Bundle of Workforce Optimization Features to Help Bring Their Vision of the Customer Experience to Life
4. International network to study the causes behind IBS
5. GeneCell International and its Subsidiary Celulas Madre Latin America Opens State-of-the-Art Clinical Laboratory, BIOCEMA, to Serve Thousands of Families in Venezuela
6. At least 1 in 5 were infected in flu pandemic, international study suggests
7. Xocai's New Xe Product Provides An Incentive For Marketing Xocolate International Corporation (MXI Corp) Distributors To Launch Their Business To A Whole New Level
8. TekLink International Inc. Announces 30% Increase in Revenue for 2012
9. A Delicious, And Healthy New Seasonal Hot Chocolate Beverage, Xocai's Sipping Xocolate, Has Been Released By Marketing Xocolate International Corporation (MXI Corp)
10. Natural Source International Introduces New 'Recipe For Health'
11. AkAsha International Launches Children's Book Series
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... ... July 06, 2015 , ... ... year for aesthetic reasons, which is why liposuction regularly ranks among the top ... however, fat reduction has become more than a way to slim down a ...
(Date:7/6/2015)... ... ... Olive Fertility Centre is proud to announce that Olive medical director Dr. Jason ... department of Family Practice. , “This award is a real honour,” says Dr Hitkari. ... changing so rapidly and we are also developing new models of patient-centred care that ...
(Date:7/6/2015)... ... 06, 2015 , ... doTERRA, the leading global essential oils company, is pleased ... Jowers held the position as Director of the Hinckley Institute at the University of ... the institute, Jowers states that he was ready for a new challenge, and out ...
(Date:7/6/2015)... ... July 06, 2015 , ... ... allows newly-diagnosed cancer patients, caregivers and medical professionals to chat with the CHN ... same cancer. , “Receiving a cancer diagnosis is often the most traumatic experience ...
(Date:7/6/2015)... ... 2015 , ... Health care systems and genomics projects have generated massive patient ... and use this “Big Data” to improve health and cut costs is now on ... Mount Sinai Health System in New York City. Physicians will have these new capabilities ...
Breaking Medicine News(10 mins):Health News:Learn How CoolSculpting® and Liposuction in Virginia Beach Help Military Members Stay the Course 2Health News:Learn How CoolSculpting® and Liposuction in Virginia Beach Help Military Members Stay the Course 3Health News:Olive Fertility Centre Physician Honoured for Teaching 2Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 2Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 3Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 4Health News:Cancer Hope Network Launches Upgraded Website to Support Cancer Patients, Caregivers 2Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 2Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 3Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 4Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 5
... shows that individuals with mild H1N1 infection may go ... in the August issue of the American Journal ... Association for Professionals in Infection Control and Epidemiology, (APIC). ... are more accurate in determining influenza infection than presence ...
... Reporter , WEDNESDAY, July 28 (HealthDay News) -- For the first ... stem cells, albeit in rabbits not humans. And the joints worked. ... weight, virtually like normal rabbits," said Dr. Jeremy Mao, senior author ... . "This was the first regeneration of the entire joint with ...
... Child Health Research shows an association between ADHD and ... have just been published online in the international ... studies at the Institute, Associate Professor Wendy Oddy, said ... from the long-term Raine Study and classified diets into ...
... Spanish . , Mushrooms are among the many ... immune system healthy. Now, Agricultural Research Service (ARS)-funded scientists have ... mushrooms enhanced the activity of critical cells in the body,s ... represent 90 percent of the total mushrooms consumed. The ...
... Postmenopausal women with diabetes taking thiazolidinediones (TZDS), including rosiglitazone ... according to a new study accepted for publication in ... Metabolism (JCEM). Men with diabetes taking both loop ... of fractures. "Our study shows that increased ...
... By Steven Reinberg HealthDay Reporter , ... reports of potentially hazardous food products were filed with ... first seven months of operation, the U.S. Food and ... requires manufacturers, processors, packers and distributors to immediately report ...
Cached Medicine News:Health News:Scientists Use Stem Cells to Help Rabbits Grow New Joints 2Health News:Scientists Use Stem Cells to Help Rabbits Grow New Joints 3Health News:Western diet link to ADHD 2Health News:FDA Cites Its Food Safety Web Site 2
(Date:7/6/2015)... , July 6, 2015  OrthoSpace Ltd. ("OrthoSpace" ... first three patients in its US Investigational Device ... 184 patient randomized, single blinded control study that ... conventional repair or partial repair for the treatment ... InSpace is currently commercially available outside of ...
(Date:7/6/2015)... PARIS , July 6, 2015 ... inventor of Cellvizio®, the multidisciplinary confocal laser endomicroscopy ... Japan,s Ministry of Health, ... Confocal Laser Endomicroscopy solution, the AQ-Flex 19 miniprobe. ... Cellvizio AQ -Flex™ 19 miniprobe is comprised of ...
(Date:7/6/2015)... , June 29, 2015 ... of the "Pharmaceutical Packaging Market in North America ... pharmaceutical packaging market in North America ... the period 2014-2019. International regulations regarding ... drug manufacturers, which in turn fuels adoption of sustainable ...
Breaking Medicine Technology:OrthoSpace Enrolls First Patients in US IDE Study 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 3North American Pharmaceutical Packaging Market 2015-2019 with Amcor, Bemis Healthcare Packaging, MeadWestvaco, Owens-Illinois & West Pharmaceutical Services Dominating 2North American Pharmaceutical Packaging Market 2015-2019 with Amcor, Bemis Healthcare Packaging, MeadWestvaco, Owens-Illinois & West Pharmaceutical Services Dominating 3
... SOUTH SAN FRANCISCO, Calif., Dec. 7, 2011 Rigel ... that Raul Rodriguez, the company,s president and chief operating ... the Oppenheimer 22nd Annual Healthcare Conference in New York ... (Logo: http://photos.prnewswire.com/prnh/20030226/RIGLLOGO ) ...
... (NYSE AMEX: IBIO ) today announced that Jules ... a Managing Director of the Company for at least the ... development activity.  Mr. Musing, formerly a Senior Executive at Johnson ... 2011.  In the course of his career in the Pharmaceutical ...
Cached Medicine Technology:Jules Musing to Lead Business Development Effort 2Jules Musing to Lead Business Development Effort 3
Onyx Liquid Embolic System is a device utilized for the pre-surgical embolization of arteriovenous malformations (AVMs)....
... P2000 Pachymeter [i.e., PalmScan P2000] device ... biometer, which incorporates A-mode pulsed-echo ultrasound,technology, ... accurately measure the corneal thickness (CT) ... PalmScan P2000 includes two software user,interfaces; ...
The Cordis ANGIOGUARD Capture Guidewire is the first embolic protection device shown in clinical testing to achieve a relative stroke reduction of 70% during carotid stenting procedures....
... TOX/See™ is a 1-step, hand-held, point-of-care device for ... in human urine. The TOX/See device can ... abused drugs in 3 to 8 minutes and ... TOX/See cassette is individually packaged to maximize convenience ...
Medicine Products: