Navigation Links
International study finds new genetic links to juvenile arthritis
Date:4/24/2013

CINCINNATI Researchers report in Nature Genetics they have increased the number of confirmed genes linked to juvenile idiopathic arthritis (JIA) from three to 17 a finding that will clarify how JIA fits into the spectrum of autoimmune disorders and help identify potential treatment targets.

Published April 21, the study involves an international research team that analyzed 2,816 JIA cases recruited from more than 40 pediatric rheumatology clinics. It was the largest collaborative patient population of JIA to date, including patient DNA samples from across the United States, Germany and United Kingdom, according to Susan Thompson, PhD, a researcher in the Division of Rheumatology at Cincinnati Children's Hospital Medical Center who was a leader for the study.

"These findings will help us understand how the long suspected genetic contributions to JIA are driving the disease process, with the ultimate goal being earlier and improved diagnosis and treatment," Thompson said.

JIA is the most common rheumatic disease of childhood that involves several different but related forms. Affecting some 50,000 children in the US, the actual cause of the disease remains unknown. JIA is considered an autoimmune disorder, in which the body's immune system mounts an attack against its own healthy tissues. JIA can be treated with medications and physical therapy, but the disease can persist for many patients into adulthood.

Prior to the current study only three genes were associated with known JIA risk, although scientists have suspected the likelihood that more genes are involved. The research team used what is known as the Immunochip array to measure variation in the genes (DNA) coding for components of the immune system for 2,816 JIA patients in the study. Those findings were compared to the DNA of 13,000 healthy controls to look for genetic differences.

The analyses re-confirmed JIA's connection to the original three gene
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. International Food Protection Training Institute Unveils New Website
2. TekLink International Inc. and Reboard GmbH Announce Strategic Partnership Providing Mobility Solutions
3. Data Devices International Announces the Introduction of the DataGauss Hard Disk Drive and Magnetic Media Degausser
4. Solatube International Celebrates Earth Day 2013 by Harnessing the Sun’s Rays with Daylighting
5. Westchester County Dentist Dr. Kenneth Magid, D.D.S. has been Selected for Fellowship in The International College of Dentists 2013
6. Johns Hopkins experts to present genetics advances at international meeting this weekend
7. Pacific Prime Wins Bupa International Top Global Distributor Award
8. BOMI International and Transwestern Partner to Offer Property and Facility Staff Skill-Enhancing Education Programs
9. AMD Global Telemedicine Reports Increase in International Adoption of Clinical Telemedicine
10. Narconon International Pledges Wholehearted Support for Rx Drug Abuse Summit Cause: “Make an Impact”
11. Sofia University Professor Karen Erlichman to Co-Lead Spiritual Directors International Leadership Institute 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... HealthDay Reporter MONDAY, Nov. 17, ... severe abusive head trauma before the age of 5 will ... In addition, among those who survive severe injuries, ... found. Abusive head trauma includes shaken baby syndrome, in ... injuries, according to background information in the study. In ...
(Date:11/18/2014)... Dennis Thompson HealthDay Reporter ... healthy people on the verge of burning out are more ... Those suffering from so-called vital exhaustion -- a toxic combination ... increased risk of developing heart disease, researchers report. "In ... stress. And I think, when that stress is left unchecked ...
(Date:11/18/2014)... -- Until recently, insect-transmitted Chagas disease was found mainly in ... way to the United States over the past few years. ... the bite of the "kissing bug," which feeds on the ... suggests that common bedbugs might be carriers as well. ... parasite. Our next step is to determine whether they are, ...
(Date:11/17/2014)... Vernon Brewer, Founder and President of World Help, ... and saw firsthand the devastating holocaust that ISIS is exacting ... Syria. , “‘Holocaust’ is not a term I use lightly, ... thousands of Christians and members of other faiths from their ... As ISIS expands, they continue to kill Christians and ...
(Date:11/17/2014)... 17, 2014 QuickChek customers and employees ... “Dog Tag” Promotion. In total, the New ... The Warriors® in support of military families both locally ... national nonprofit dedicated to restoring a sense of self, ... service members and our military families. , Throughout ...
Breaking Medicine News(10 mins):Health News:Head Trauma in Abused Babies, Toddlers Can Have Lifelong Impact 2Health News:Head Trauma in Abused Babies, Toddlers Can Have Lifelong Impact 3Health News:Head Trauma in Abused Babies, Toddlers Can Have Lifelong Impact 4Health News:Feeling 'Worn Out'? Your Heart May Pay the Price 2Health News:Feeling 'Worn Out'? Your Heart May Pay the Price 3Health News:Bedbugs Could Be Potential New Source of Tropical Disease in U.S. 2Health News:Bedbugs Could Be Potential New Source of Tropical Disease in U.S. 3Health News:President of WORLD HELP Travels to Iraq and Jordan; Finds Religious Holocaust Being Executed by ISIS 2Health News:President of WORLD HELP Travels to Iraq and Jordan; Finds Religious Holocaust Being Executed by ISIS 3Health News:QuickChek Gives Big Support to Hope For The Warriors One Dollar at a Time 2
... and successful initial testing of a new tool that ... an operation is underway, so that surgeons can remove ... patients, survival. The report appears in ACS, journal ... out that cancer can recur if tumor cells remain ...
... known that hard training can lead to degradation of muscle ... to counter this but surprisingly there has to date been ... Preliminary data showing that nutritional supplements given after exercise ... provided by Ren van den Hoven and colleagues in the ...
... Canadian Journal of Cardiology ( www.onlinecjc.ca ) ... imaging methods. This study is important for patients worried ... heart. X-ray based methods have greatly improved the diagnosis ... of radiation exposure. New imaging methods offer ...
... October 19, 2011 Poorly managed pain in the ... consequences, causing physiological and behavioral instability in preterm infants ... systems, and developing brains. In a study published in ... that breastfeeding during minor procedures mitigated pain in preterm ...
... therapies that specifically target signaling pathways in cancer cells ... patients taking them, which can adversely affect patients, quality ... in the Journal of the National Cancer ... antineoplastic agents have been introduced that inhibit specific cellular ...
... team of Canadian researchers has sequenced the genome of ... industrial hemp and marijuana, and in the process revealed ... properties., Jon Page is a plant biochemist and adjunct ... explains that a simple genetic switch is likely responsible ...
Cached Medicine News:Health News:Improving training efficiency in horses 2Health News:Can breastfeeding reduce pain in preterm infants? 2Health News:Antineoplastic agents associated with thyroid dysfunction 2Health News:How hemp got high: Canadian scientists map the cannabis genome 2
(Date:11/18/2014)... November 18, 2014 This report ... the overall new requirements of application dossiers for medical ... but also provides the guidance of practical operation ... products entry into the Chinese medical device market. ... market is one of segment market of the most ...
(Date:11/18/2014)...  Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ) announced ... December 8, 2014 at 9:00 a.m. Eastern Time to discuss ... American Society of Hematology Annual Meeting and Exposition.  ... dialing 877-443-5662 or access the webcast at www.isispharm.com .  ... at the same address. ABOUT ISIS PHARMACEUTICALS, ...
(Date:11/18/2014)... Tocagen Inc. today announced that interim data ... at six months for recurrent high grade glioma (HGG) ... to published benchmarks. HGG includes glioblastoma, the most common ... were delivered in an oral presentation at the 19 th ... Society for Neuro-Oncology (SNO) by Tim Cloughesy , ...
Breaking Medicine Technology:Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation in China (2014 Edition) 2Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation in China (2014 Edition) 3Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation in China (2014 Edition) 4Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation in China (2014 Edition) 5Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation in China (2014 Edition) 6Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation in China (2014 Edition) 7Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation in China (2014 Edition) 8Isis Pharmaceuticals to Host Webcast to Discuss ISIS-FXI Rx Data Presented at the ASH Annual Meeting 2Isis Pharmaceuticals to Host Webcast to Discuss ISIS-FXI Rx Data Presented at the ASH Annual Meeting 3Interim Data Show Increased Median Overall Survival of Recurrent Brain Cancer Patients Treated with Tocagen's Toca 511 & Toca FC, Compared to Published Benchmarks 2Interim Data Show Increased Median Overall Survival of Recurrent Brain Cancer Patients Treated with Tocagen's Toca 511 & Toca FC, Compared to Published Benchmarks 3Interim Data Show Increased Median Overall Survival of Recurrent Brain Cancer Patients Treated with Tocagen's Toca 511 & Toca FC, Compared to Published Benchmarks 4Interim Data Show Increased Median Overall Survival of Recurrent Brain Cancer Patients Treated with Tocagen's Toca 511 & Toca FC, Compared to Published Benchmarks 5
... SILVER SPRING, Md., May 6, 2011 The U.S. Food ... allow a new group of patients at risk of stroke ... RX Acculink carotid stent. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... neck bring blood to the brain. The blood flow in ...
... BEACH, Calif., May 6, 2011 Yesterday, the ... Novartis drug Afinitor® (everolimus) for the treatment of ... less than five percent of all pancreatic cancer ... aggressive than the more common form of pancreatic ...
Cached Medicine Technology:FDA Expands Approved Use For Carotid Stent 2FDA Expands Approved Use For Carotid Stent 3FDA Approves Novartis Drug Afinitor to Treat Pancreatic Neuroendocrine Tumors 2
... The Vitros 250 is ... meet requirements in multiple environments ... large hospitals, clinics and satellite ... features on-board dilution, and can ...
The IMx system is an automated analyzer designed to perform microparticle enzyme immunoassay (MEIA), fluorescence polarization immunoassay (FPIA) and ion capture technologies....
Architect i2000 is a flexible solution for your evolving laboratory providing high throughput and walkaway time with built-in flexibility....
... The Bayer Immuno 1 provides ... immunoassay instrument with over 50 ... endocrinology, tumor marker, therapeutic drug, ... can be performed on a ...
Medicine Products: