Navigation Links
International study finds new genetic links to juvenile arthritis
Date:4/24/2013

CINCINNATI Researchers report in Nature Genetics they have increased the number of confirmed genes linked to juvenile idiopathic arthritis (JIA) from three to 17 a finding that will clarify how JIA fits into the spectrum of autoimmune disorders and help identify potential treatment targets.

Published April 21, the study involves an international research team that analyzed 2,816 JIA cases recruited from more than 40 pediatric rheumatology clinics. It was the largest collaborative patient population of JIA to date, including patient DNA samples from across the United States, Germany and United Kingdom, according to Susan Thompson, PhD, a researcher in the Division of Rheumatology at Cincinnati Children's Hospital Medical Center who was a leader for the study.

"These findings will help us understand how the long suspected genetic contributions to JIA are driving the disease process, with the ultimate goal being earlier and improved diagnosis and treatment," Thompson said.

JIA is the most common rheumatic disease of childhood that involves several different but related forms. Affecting some 50,000 children in the US, the actual cause of the disease remains unknown. JIA is considered an autoimmune disorder, in which the body's immune system mounts an attack against its own healthy tissues. JIA can be treated with medications and physical therapy, but the disease can persist for many patients into adulthood.

Prior to the current study only three genes were associated with known JIA risk, although scientists have suspected the likelihood that more genes are involved. The research team used what is known as the Immunochip array to measure variation in the genes (DNA) coding for components of the immune system for 2,816 JIA patients in the study. Those findings were compared to the DNA of 13,000 healthy controls to look for genetic differences.

The analyses re-confirmed JIA's connection to the original three genes, identified a link to the 14 new genes and pointed to the possibility that another 11 genetic regions may be implicated. The scientists stressed that their work continues in order to identify additional genetic links and also begin conducting functional studies to pinpoint disease processes.

Although the current study substantially increases the number of confirmed susceptibility genes for JIA, the researchers said their data indicate that additional genetic risk factors still remain to be discovered.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Related medicine news :

1. International Food Protection Training Institute Unveils New Website
2. TekLink International Inc. and Reboard GmbH Announce Strategic Partnership Providing Mobility Solutions
3. Data Devices International Announces the Introduction of the DataGauss Hard Disk Drive and Magnetic Media Degausser
4. Solatube International Celebrates Earth Day 2013 by Harnessing the Sun’s Rays with Daylighting
5. Westchester County Dentist Dr. Kenneth Magid, D.D.S. has been Selected for Fellowship in The International College of Dentists 2013
6. Johns Hopkins experts to present genetics advances at international meeting this weekend
7. Pacific Prime Wins Bupa International Top Global Distributor Award
8. BOMI International and Transwestern Partner to Offer Property and Facility Staff Skill-Enhancing Education Programs
9. AMD Global Telemedicine Reports Increase in International Adoption of Clinical Telemedicine
10. Narconon International Pledges Wholehearted Support for Rx Drug Abuse Summit Cause: “Make an Impact”
11. Sofia University Professor Karen Erlichman to Co-Lead Spiritual Directors International Leadership Institute 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star ... , Millions of individuals in the United States and Canada wear eyeglasses. Once considered ... both correct vision and make a fashion statement. Even celebrities use glasses as a ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
Breaking Medicine Technology: