Navigation Links
International study finds new genetic links to juvenile arthritis

CINCINNATI Researchers report in Nature Genetics they have increased the number of confirmed genes linked to juvenile idiopathic arthritis (JIA) from three to 17 a finding that will clarify how JIA fits into the spectrum of autoimmune disorders and help identify potential treatment targets.

Published April 21, the study involves an international research team that analyzed 2,816 JIA cases recruited from more than 40 pediatric rheumatology clinics. It was the largest collaborative patient population of JIA to date, including patient DNA samples from across the United States, Germany and United Kingdom, according to Susan Thompson, PhD, a researcher in the Division of Rheumatology at Cincinnati Children's Hospital Medical Center who was a leader for the study.

"These findings will help us understand how the long suspected genetic contributions to JIA are driving the disease process, with the ultimate goal being earlier and improved diagnosis and treatment," Thompson said.

JIA is the most common rheumatic disease of childhood that involves several different but related forms. Affecting some 50,000 children in the US, the actual cause of the disease remains unknown. JIA is considered an autoimmune disorder, in which the body's immune system mounts an attack against its own healthy tissues. JIA can be treated with medications and physical therapy, but the disease can persist for many patients into adulthood.

Prior to the current study only three genes were associated with known JIA risk, although scientists have suspected the likelihood that more genes are involved. The research team used what is known as the Immunochip array to measure variation in the genes (DNA) coding for components of the immune system for 2,816 JIA patients in the study. Those findings were compared to the DNA of 13,000 healthy controls to look for genetic differences.

The analyses re-confirmed JIA's connection to the original three genes, identified a link to the 14 new genes and pointed to the possibility that another 11 genetic regions may be implicated. The scientists stressed that their work continues in order to identify additional genetic links and also begin conducting functional studies to pinpoint disease processes.

Although the current study substantially increases the number of confirmed susceptibility genes for JIA, the researchers said their data indicate that additional genetic risk factors still remain to be discovered.


Contact: Nick Miller
Cincinnati Children's Hospital Medical Center

Related medicine news :

1. International Food Protection Training Institute Unveils New Website
2. TekLink International Inc. and Reboard GmbH Announce Strategic Partnership Providing Mobility Solutions
3. Data Devices International Announces the Introduction of the DataGauss Hard Disk Drive and Magnetic Media Degausser
4. Solatube International Celebrates Earth Day 2013 by Harnessing the Sun’s Rays with Daylighting
5. Westchester County Dentist Dr. Kenneth Magid, D.D.S. has been Selected for Fellowship in The International College of Dentists 2013
6. Johns Hopkins experts to present genetics advances at international meeting this weekend
7. Pacific Prime Wins Bupa International Top Global Distributor Award
8. BOMI International and Transwestern Partner to Offer Property and Facility Staff Skill-Enhancing Education Programs
9. AMD Global Telemedicine Reports Increase in International Adoption of Clinical Telemedicine
10. Narconon International Pledges Wholehearted Support for Rx Drug Abuse Summit Cause: “Make an Impact”
11. Sofia University Professor Karen Erlichman to Co-Lead Spiritual Directors International Leadership Institute 2013
Post Your Comments:
(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... of the most popular and least understood books in the Holy Scriptures, Revelation. The ... that have baffled scholars for centuries. Many have tossed it off as mere rubbish, ...
(Date:10/13/2017)... ... , ... “The Journey: From the Mountains to the Mission Field”: the story ... the Philippines. “The Journey: From the Mountains to the Mission Field” is the creation ... has taught all ages and currently teaches a class of ladies at her church, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
(Date:9/18/2017)... Pa. and KALAMAZOO, Mich. , Sept. 18, ... , and OptiMed Specialty Pharmacy of ... to offer a strategic hub service that expedites and ... sought-after personal spirometer, Spiro PD 2.0, and wellness management ... spirometer is a medical device used to measure lung ...
(Date:9/12/2017)... N.J. , Sept. 12, 2017  Consumer reviews on the ... Hearing as the number one company for hearing aids, ranking ... and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high ...
Breaking Medicine Technology: