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International panel revises 'McDonald Criteria' for diagnosing multiple sclerosis
Date:3/9/2011

rence scan be performed at least 30 days after the initial clinical event; this is no longer a requirement.)
  • Dissemination in space can be demonstrated with at least one T2 lesion in at least two our of four areas of the central nervous system: periventricular, juxtacortical, infratentorial, or spinal cord. These lesions need not be gadolinium enhanced.

    In the case of diagnosing primary-progressive MS, aspects of the previous criteria remain, but the MAGNIMS recommendations for demonstrating dissemination in space were incorporated to harmonize with other 2010 updates. As shown in Table 1, diagnosing primary-progressive MS requires one year of disease progression (determined retrospectively or prospectively), plus at least 2 out of these 3 criteria: dissemination in space in the brain based on at least 1 T2 lesion in periventricular, juxtacortical or infratentorial regions; dissemination in space in the spinal cord based on at least 2 T2 lesions; or positive cerebrospinal fluid (CSF) findings.

    While the International Panel has provided revised and simplified criteria for MS diagnosis, recommendations for further testing of the Criteria are made as well, to bolster the scientific evidence supporting the 2010 recommendations.

    Comment: The 2010 Revisions to the McDonald Diagnostic Criteria for MS should speed and make easier and more certain the diagnosis of MS. As with the original Criteria, these need prospective study, and it is expected that additional research will result in further refinements.

    "Efforts like the work of this international panel illustrate the National MS Society's role as a convening force to push forward progress that not only improves clinical care, but also identifies research opportunities and gaps," noted Timothy Coetzee, PhD, the Society's chief research officer. "The paper highlights the need for research to identify additional biological markers of MS and its subtypes. This gap impedes p
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  • Contact: Arney Rosenblat
    arney.rosenblat@nmss.org
    212-476-0436
    National Multiple Sclerosis Society
    Source:Eurekalert

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