Navigation Links
International group finds 11 new Alzheimer's genes to target for drug discovery
Date:10/27/2013

PHILADELPHIA - The largest international Alzheimer's disease genetics collaboration to date has found 11 new genetic areas of interest that contribute to late onset Alzheimer's Disease (LOAD), doubling the number of potential genetics-based therapeutic targets to interrogate. The study, published in Nature Genetics, provides a broader view of genetic factors contributing to the disease and expands the scope of disease understanding to include new areas including the immune system, where a genetic overlap with other neurodegenerative diseases such as multiple sclerosis and Parkinson's disease was identified.

"Human genetic studies are being used with increased frequency to validate new drug targets in many diseases. Here we greatly increased the list of possible drug target candidates for Alzheimer's disease, finding as many new significant genes in this one study as have been found in the last 15 years combined," said co-senior author Gerard Schellenberg, PhD, director of the Alzheimer's Disease Genetics Consortium (ADGC) and professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania. "This international effort has given us new clues into the steps leading to and accelerating Alzheimer's disease. We can add these new genetic clues to what we already know and try to piece together the mechanism of this complex disease."

Pooling resources through the International Genomics of Alzheimer's Project (IGAP), the collaborative team collected 74,076 patients and controls from 15 countries. After a two stage meta-analysis, the group found some genes which confirmed known biological pathway of Alzheimer's disease, including the role of the amyloid pathway (SORL1 , CASS4) and tau (CASS4, FERMT2). Newly discovered genes involved in the immune response and inflammation (HLA-DRB5/DRB1, INPP5D, MEF2C) reinforced a pathway implied by previous work (on CR1, TREM2). Additional genes related
'/>"/>

Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. International breast health global summit will focus on supportive care and quality of life
2. International conference to explore health of descendants of transatlantic slave trade
3. Kessler Foundation researchers present at first International Congress on Cognition in MS
4. Internationally known expert in ovarian cancer to be honored at the ASCO Annual Meeting
5. Nobel laureate to keynote international pharmaceutical conference at URI
6. International Nanomedicine Conference bound for Sydney: July 2-4, 2012
7. June 2012 marks a milestone for International Urogynecology Associates as Dr. Robert D. Moore and Dr. John R. Miklos perform their 24th Neovagina Surgery in 24 months
8. Heavy Duty Alternators and Starters Expert Elreg Distributors Ltd. Meets Needs of International Market with Launch of Spanish Website
9. The US Drug Watchdog Now Urges Plaintiffs Law Firms Worldwide To Contact Them About A Possible International Effort To Help Victims Of Defective Drugs Or Medical Devices
10. RMAX International to donate Recuper8 - a free, health - restoring program to Everyone in Uniform
11. International symposium on veterinary rehabilitation and physical therapy to be held in Vienna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... Plains, NJ (PRWEB) , ... August 31, 2015 ... ... practice! Garden State Urology was formed in 2008, the result of a merger ... the principle that by working cooperatively, they could provide more cost-effective and higher ...
(Date:8/31/2015)... Scotch Plains, NJ (PRWEB) , ... August 31, 2015 , ... NJ Top Docs Presents, ... Doc”!, Born and raised in Park Ridge, New Jersey, Dr. Michael Betsy graduated from Don ... and ice hockey and served as team captain in both sports in his senior year. ...
(Date:8/31/2015)... ... 31, 2015 , ... Dr. Stewart Shofner of Shofner Vision Center ... Month. Only a comprehensive eye examination can diagnose amblyopia. According to the National ... children, affecting approximately 2 to 3 out of every 100 children. , Dr. ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... company announced today that it has officially launched a new website and company ... and brand refresh are more closely aligned with the company’s strategic vision for ...
(Date:8/31/2015)... ... August 31, 2015 , ... Three Bakers Gluten Free Bakery launched the ... more relevant and easy-to-find information on their offering of gluten-free breads and pizzas, living ... an important way for us to share information about our gluten free product offerings, ...
Breaking Medicine News(10 mins):Health News:NJ Top Docs Presents, Garden State Urology! 2Health News:NJ Top Docs Presents, Dr. Michael Betsy! 2Health News:NJ Top Docs Presents, Dr. Michael Betsy! 3Health News:Renowned Eye Surgeon Dr. Stewart Shofner Shares Information about the Causes of Lazy Eye During Amblyopia Awareness Month 2Health News:Renowned Eye Surgeon Dr. Stewart Shofner Shares Information about the Causes of Lazy Eye During Amblyopia Awareness Month 3Health News:Diablo Publications Launches New Company Website 2Health News:Diablo Publications Launches New Company Website 3Health News:Three Bakers Gluten Free Bakery Announces Launch of New Website 2
... banned all imports of poultry from UK to prevent the spread ... said in statement// as soon as the British ministry informed them ... ,This virus is less dangerous to humans than the H5N1 ... worker in UK. Its incidence of late is on the rise ...
... turn camel milk, a healthier option than cow's milk, into the ... method of milking normally yields some 1.5 litres of milk per ... litres produced by cows. //Yagil, however, says he has developed a ... ,Traditionally seen as riding and pack animals, camels are hugely ...
... a high risk of contracting severe injuries, more specifically sideswipe injuries ... which can be cited in the latest edition of Medical Journal ... driver resting his/her hands on the car window, in a relaxed ... to the protruding limb/elbow. ,In an attempt to identify ...
... the levels of a hormone found in the stomach ... activity in overweight and obese people. // ,The ... International Journal of Obesity. ,The research team ... oxyntomodulin to fifteen overweight volunteers from Hammersmith Hospital. They ...
... UK couples go abroad in order to undergo fertility treatment. ... own country is that there is a long waiting list ... //were removed by a law. Hence European fertility clinics are ... and Embryology Authority (HFEA) is warning people about the mad ...
... IVF on the grounds that she was a lesbian, ... ,According to Lambda Legal lawyer Jennifer Pizer ... violates California civil rights law. The suit was announced ... doctors however claimed that being fundamental Christians prevented them ...
Cached Medicine News:Health News:Milking the ship of the desert for 'white gold' 2Health News:Watch Out! Sideswipe Elbow Injuries On The Rise 2Health News:Lesbian Sues Doctors 2
(Date:8/31/2015)... , Aug. 31, 2015  Qualcomm Incorporated ... subsidiary, Qualcomm Life, Inc., is collaborating ... chronic care management solutions powered by Qualcomm Life,s ... Platform to enable continuous care, informed interventions and ... announced at Qualcomm Life,s annual Connect 2015 ...
(Date:8/31/2015)... PARK, Calif. , Aug. 31, 2015 /PRNewswire/ ... company focused on the emerging field of regenerative ... successfully dosed at Chicago -based ... clinical trial evaluating activity of escalating doses of ... with sensory and motor complete cervical spinal cord ...
(Date:8/31/2015)...  QT Vascular Ltd., together with its subsidiaries ... its subsidiaries, the "Group"), a global company engaged ... therapeutic solutions for the minimally invasive treatment of ... the below-the-knee ("BTK") cohort of patients in the ... on August 15, 2015 at the 5th Annual ...
Breaking Medicine Technology:Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 2Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 3Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 4Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 4Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 6Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 2Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 3Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 4
... May 3, 2012  Abbott (NYSE: ABT ), ... plans to establish its first nutrition research and development ... leading contract research organization. The Abbott Nutrition R&D Center ... affordable nutrition products for the country and enable the ...
... 2012  Hill-Rom Holdings, Inc. (NYSE: HRC ) announced ... year 2012 third quarter dividend of $0.125 per share. This ... record as of the close of business on June 15, ... Hill-Rom is a leading worldwide manufacturer and provider of ...
Cached Medicine Technology:Abbott Announces Collaboration with Syngene to Open First Nutrition R&D Center in India 2Abbott Announces Collaboration with Syngene to Open First Nutrition R&D Center in India 3Abbott Announces Collaboration with Syngene to Open First Nutrition R&D Center in India 4
... first time, the Integrated Cytometry Solution ... post-analytical solution coupled with complete LIS ... steps a sample undergoes - and ... one - it delivers a progressive ...
Convective Air Warming Blankets...
MAMMOMAT 3000 Nova supports high-volume screening as well as interventional diagnostics. Versatile procedural capabilities include magnification, stereotactic biopsy, needle localization, and specime...
Inquire...
Medicine Products: