Navigation Links
International group finds 11 new Alzheimer's genes to target for drug discovery
Date:10/27/2013

PHILADELPHIA - The largest international Alzheimer's disease genetics collaboration to date has found 11 new genetic areas of interest that contribute to late onset Alzheimer's Disease (LOAD), doubling the number of potential genetics-based therapeutic targets to interrogate. The study, published in Nature Genetics, provides a broader view of genetic factors contributing to the disease and expands the scope of disease understanding to include new areas including the immune system, where a genetic overlap with other neurodegenerative diseases such as multiple sclerosis and Parkinson's disease was identified.

"Human genetic studies are being used with increased frequency to validate new drug targets in many diseases. Here we greatly increased the list of possible drug target candidates for Alzheimer's disease, finding as many new significant genes in this one study as have been found in the last 15 years combined," said co-senior author Gerard Schellenberg, PhD, director of the Alzheimer's Disease Genetics Consortium (ADGC) and professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania. "This international effort has given us new clues into the steps leading to and accelerating Alzheimer's disease. We can add these new genetic clues to what we already know and try to piece together the mechanism of this complex disease."

Pooling resources through the International Genomics of Alzheimer's Project (IGAP), the collaborative team collected 74,076 patients and controls from 15 countries. After a two stage meta-analysis, the group found some genes which confirmed known biological pathway of Alzheimer's disease, including the role of the amyloid pathway (SORL1 , CASS4) and tau (CASS4, FERMT2). Newly discovered genes involved in the immune response and inflammation (HLA-DRB5/DRB1, INPP5D, MEF2C) reinforced a pathway implied by previous work (on CR1, TREM2). Additional genes related
'/>"/>

Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. International breast health global summit will focus on supportive care and quality of life
2. International conference to explore health of descendants of transatlantic slave trade
3. Kessler Foundation researchers present at first International Congress on Cognition in MS
4. Internationally known expert in ovarian cancer to be honored at the ASCO Annual Meeting
5. Nobel laureate to keynote international pharmaceutical conference at URI
6. International Nanomedicine Conference bound for Sydney: July 2-4, 2012
7. June 2012 marks a milestone for International Urogynecology Associates as Dr. Robert D. Moore and Dr. John R. Miklos perform their 24th Neovagina Surgery in 24 months
8. Heavy Duty Alternators and Starters Expert Elreg Distributors Ltd. Meets Needs of International Market with Launch of Spanish Website
9. The US Drug Watchdog Now Urges Plaintiffs Law Firms Worldwide To Contact Them About A Possible International Effort To Help Victims Of Defective Drugs Or Medical Devices
10. RMAX International to donate Recuper8 - a free, health - restoring program to Everyone in Uniform
11. International symposium on veterinary rehabilitation and physical therapy to be held in Vienna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... DiaSorin has announced that their new webinar , ... guest speaker Dr. Gregory A. Plotnikoff, a physician and ... Integrative Medicine. Dr. Plotnikoff serves as an integrative medicine ... Healing and as Senior Consultant, Center for Health Care ... as a co-editor of the new journal Global Advances ...
(Date:8/27/2014)... August 28, 2014 National Resident ... in the Association for Medical Education in Europe (AMEE) ... Milan, Italy August 30 – September 3, 2014. ... the international medical education community, share the benefits of ... strengthen resident physician placement in countries throughout the world. ...
(Date:8/27/2014)... Delta, a reliable supplier of high quality ... D7R Dozers to its used bulldozer collection. ... that all these items are offered with deep discounts. ... Delta’s market share in the coming September. , ... offer; he has much confidence in the discounted Used ...
(Date:8/27/2014)... Philadelphia, PA. Inc. magazine ranked Holganix as ... an exclusive ranking of the nation’s fastest-growing privately held ... the most important segment of the economy - America’s ... as members of the Inc. 500 list include Dell, ... of world’s greatest companies have had their start on ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Reviewing the ... will now be easier for the public when using ... that are promoted in all 50 states in the ... , The different insurers that are generating the rates ... possible for adults to use the programmed system without ...
Breaking Medicine News(10 mins):Health News:DiaSorin Announces New Webinar in Their Annual Vitamin D Series 2Health News:DiaSorin Announces New Webinar in Their Annual Vitamin D Series 3Health News:National Resident Matching Program International (NRMPI) to Exhibit at the 2014 AMEE Conference 2Health News:Reliable Supplier Delta Adds New Items To Its Used Bulldozer Collection 2Health News:Inc Magazine Unveils 33rd Annual List of America's Fastest-Growing Private Companies - the Inc. 500 2Health News:Home Insurance Prices for All 50 States Now Supplied at Consumer Insurance Portal Online 2
... Pacific Dental Services (PDS(TM)) provided dentistry to the Community of ... Los Angeles , Over 250 employees, affiliated dentists and family members helped those ... in need , World Impact, Inc.(C) was a ... ...
... obesity epidemic in explaining the troubling trend , , TUESDAY, ... pronounced reduction in risk factors for heart disease is ... that the trend has flattened, starting at the beginning ... date back a fair amount of time, but now ...
... 11 The number of heart attack patients,admitted to ... smoking ban were implemented, according to a Henry Ford,Hospital ... hospital admissions from,1999-2006 in Michigan for what is known ... a smoking ban could lead to 3,340 fewer,admissions annually., ...
... Anthem Blue Cross and,Blue Shield in Maine is ranked ... according to the current (Nov. 17) issue of U.S. ... recognition as,one of the nation,s best health plans is ... member satisfaction and NCQA,accreditation., "We work hard to ...
... in Thermotherapy, ALAMEDA, Calif. and PITTSBURGH, Nov. ... today the introduction of ReBound, a new and,innovative ... and joint contractures using radio frequency (RF) diathermy. ... treatment systems,to the physical therapy and athletic training ...
... and prevention, new report finds , , TUESDAY, Nov. 11 ... of educational materials, and meager data collection are hindering ... driving in the United States and aggressively tackle the ... Foundation (NSF) released its findings Tuesday as part of ...
Cached Medicine News:Health News:Watts Powerhouse Church Receives a Facelift Through the Volunteers of Pacific Dental Services(R) 2Health News:Watts Powerhouse Church Receives a Facelift Through the Volunteers of Pacific Dental Services(R) 3Health News:After Decades, Decreases in Heart Risk Factors Level Off 2Health News:Study: Smoking Ban Would Help Reduce Heart Attack Admissions 2Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 2Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 3Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 4Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 5Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 6Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 7Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 8Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 9Health News:Game Ready(TM) and ReGear Life Sciences(TM) Bring Innovative New Heat Therapy to Market 2Health News:Game Ready(TM) and ReGear Life Sciences(TM) Bring Innovative New Heat Therapy to Market 3Health News:States Asleep at the Wheel in Fighting Drowsy Driving 2
(Date:8/27/2014)... Research and Markets  has announced the addition of ... report to their offering. The Global ... in-depth study on the current state of the global ... basic overview of the industry including definitions, classifications, applications ... is provided for the international markets including development trends, ...
(Date:8/27/2014)... Aug. 27, 2014 Decision Resources Group finds ... Memphis health system and hospital ... integration, with rivals Methodist Le Bonheur Healthcare and Baptist ... to coordinate patient care. In addition, a national contract ... most health plan enrollment in the Memphis ...
(Date:8/27/2014)... , August 27, 2014 ResearchMoz ... States  Laparoscopes Market Outlook to 2020. New report, ... market data on the United States Laparoscopes market ... dollars, volume (in units) and average prices (in US ... Laparoscopes and Flexible Tip Video Laparoscopes), Robotic Surgical Systems ...
Breaking Medicine Technology:Global Pulse Oximeter Industry Report 2014 2Memphis-area Health Systems Turn Attention to Clinical Integration 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 3United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 4United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 5
... Saturday, August 20, veterinary cardiologists are going to the ... Heart Health Tour will stop with a soundproof medical ... Dog Park. (Photo:   http://photos.prnewswire.com/prnh/20110815/CG52446 ) ... veterinarians will be available to answer questions for dog ...
... 2011 For the first time, the U.S. ... clarifying how benefit-risk determinations are made during premarket ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) Released today, the ... regulatory pathway for high-risk medical devices. The recommendations ...
Cached Medicine Technology:Free Dog Heart Health Screenings Available August 20 in Providence 2FDA Proposes Guidelines That Clarify Benefit-Risk Determinations for Medical Devices 2
For the quantitative determination of aspartate aminotransferase (AST) in human serum. The reagents are used in routine examination and monitoring of therapy and relapses....
Intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma. Reaction: Kinetic. Wavelength: 340 nm. Linearity: 440 U/L at 30C. Liquid buffer and dry powder r...
The Midas II Stainer is an automated slide stainer designed for use in hematology and microbiology laboratories....
... 44 is an "assembly-line worker" for routine ... cytology laboratories. It automatically stains big quantities ... increased large number of reagent stations in ... a high throughput. Up to 12 baskets ...
Medicine Products: