Navigation Links
International consortium announces the 1000 Genomes Project
Date:1/22/2008

echnologies and novel computational methods, we hope to give biomedical researchers a genome-wide map of variation down to the 1 percent level. This will change the way we carry out studies of genetic disease.

With current approaches, researchers can search for two types of genetic variants related to disease. The first type is very rare genetic variants that have a severe effect, such as the variants responsible for causing cystic fibrosis and Huntingtons disease. To find these rare variants, which typically affect fewer than one in 1,000 people, researchers often must spend years on studies involving affected families. However, most common diseases, such as diabetes and heart disease, are influenced by more common genetic variants. Most of these common variants have weak effects, perhaps increasing risk of a common condition by 25 percent or less. Recently, using a new approach known as a genome-wide association study, researchers have been able to search for these common variants.

Between these two types of genetic variants very rare and fairly common we have a significant gap in our knowledge. The 1000 Genomes Project is designed to fill that gap, which we anticipate will contain many important variants that are relevant to human health and disease, said David Altshuler, M.D., Ph.D., of Massachusetts General Hospital in Boston and the Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University in Cambridge, Mass., who is the consortiums co-chair and was a leader of the HapMap Consortium.

One use of the new catalog will be to follow up genome-wide association studies. Investigators who find that a part of the genome is associated with a disease will be able to look it up in the catalog, and find almost all variants in that region. They will then be able to conduct functional studies to see whether any of the catalogued variants directly contribute to the disease.

The 1000 Genomes Project builds
'/>"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Susan G. Komen for the Cure Sharing Grassroots Advocacy Knowledge With International Representatives in Intensive Dallas Training Session
2. Synutra International, Inc. Amends August 2005 Current Report on Form 8-K and Annual Report on Form 10-K for the Fiscal Year Ended March 31, 2007
3. MINRAD International, Inc. Announces Appointment of Charles R. Trego, Jr. to CFO & EVP
4. International Isotopes Inc. Names James Mayer as Chief Operating Officer
5. International brain aging expert challenges the existence of Alzheimers as a disease
6. EHE International Supports the American Liver Foundations Efforts at Raising Awareness for Hepatitis
7. QED International Associates Announces Changes to the HealthShares(TM) Emerging Cancer Index
8. International Sports Sciences Associations Ten Best Resolutions for Better Health in 2008
9. Joint Commission International Achieves Accreditation from ISQua
10. International Development Expert to Lead the Pan American Health and Education Foundation
11. Natural Nutrition Launches Long Life Cocktail with International Television Ad Campaign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... The inaugural single day event in Japan will ... Gardens in Tokyo. Clinical data scientists will meet and discuss ... second single day event in China will be ... clinical data scientists attending this event will discuss topics around ... display data collected in clinical studies and beyond. , ...
(Date:9/23/2014)... COLUMBIA, Mo. Infants, vocalizations throughout the first ... crying and cooing to forming syllables and first ... the amount of vocalizations may differ between hearing ... shows that infant vocalizations are primarily motivated by ... infants with profound hearing loss who received cochlear ...
(Date:9/23/2014)... of published studies found that FDG-PET technology is ... disease in regions where infections like histoplasmosis or ... suspicious for cancer could lead to unnecessary tests ... and mortality. , Histoplasmosis and other fungal ... concentrated in bird droppings and are found in ...
(Date:9/23/2014)... World of Home Fitness is committed ... recently, the gym has been raising money to support ... the year, World of Home Fitness has participated in ... Over the summer, World of Home Fitness raised more ... Fitness program, participants helped feed seniors "one rep at ...
(Date:9/23/2014)... As a consumer in today’s world, ... It’s difficult to trust testimonials that are supplied by ... manipulate their customers into saying anything. , Consumer advocacy ... to lack in depth coverage on a particular market ... to fix this issue and focus on exposing the ...
Breaking Medicine News(10 mins):Health News:PhUSE Further Expands its Global Community Into the Asian Region 2Health News:Infant cooing, babbling linked to hearing ability, MU researcher finds 2Health News:Study questions accuracy of lung cancer screens in some geographic regions 2Health News:World of Home Fitness Supports Meals on Wheels 2Health News:Consumer Health Reports Debuts Revolutionary Review Website 2
... for, immunization against diphtheria, tetanus, pertussis, polio and Haemophilus ... ... LYON, France, June 23 Sanofi,Pasteur, the vaccines division of ... Administration (FDA) has licensed Pentacel(R),Diphtheria and Tetanus Toxoids and Acellular ...
... of persistent, recent-onset symptoms linked to ovarian cancer ... quickly and abdominal bloating when combined with the ... ovarian cancer by 20 percent, according to new findings ... online today in CANCER . , Research has ...
... Delivery Unit at The Children,s,Hospital of Philadelphia, the ... birth defects, PHILADELPHIA, June 22 Hundreds ... Hospital of Philadelphia for,the 12th Annual Fetal Surgery ... been followed by the Center for Fetal Diagnosis ...
... are struggling with the health fallout caused by a lack ... Most women don,t need a survey to tell them a ... too sluggish to make it through the day with vigor. ... moms, empty-nesters or grandmothers, many -- if not most -- ...
... best in those under 80, could ease expected worldwide shortfall ... blood substitute product called HBOC-201 proved safe and effective in ... reports. , In all, 688 patients, ages 18 and ... unit of blood (about one pint) or an equivalent one ...
... India, June 20 The United States,has provided ... the Children to assist people affected by the ... Shortages have emerged in recent months because the ... rapidly growing rat infestations in,crop-growing areas. With funds ...
Cached Medicine News:Health News:U.S. FDA Licenses Sanofi Pasteur's New Pediatric Combination Vaccine, Pentacel(R) 2Health News:U.S. FDA Licenses Sanofi Pasteur's New Pediatric Combination Vaccine, Pentacel(R) 3Health News:U.S. FDA Licenses Sanofi Pasteur's New Pediatric Combination Vaccine, Pentacel(R) 4Health News:U.S. FDA Licenses Sanofi Pasteur's New Pediatric Combination Vaccine, Pentacel(R) 5Health News:Symptom screening plus a simple blood test improves early detection of ovarian cancer 2Health News:12th Annual Fetal Surgery Family Reunion Gathers Families From Across the U.S. and Canada 2Health News:12th Annual Fetal Surgery Family Reunion Gathers Families From Across the U.S. and Canada 3Health News:So Much to Do, So Little Sleep 2Health News:So Much to Do, So Little Sleep 3Health News:Blood Substitute Found Safe in Large Phase III Trial 2
(Date:9/23/2014)... , Sept. 23, 2014 Market Snapshot: Transcatheter Heart Valve 2007 to ... France , Italy , UK, Spain ... 2007 to 2020 - Europe ( Germany ... Spain )" provides quantitative analysis of the transcatheter heart valves market ... revenue and volume over the 2007–2020 period and key company share data by ...
(Date:9/23/2014)... , Sept. 23, 2014  SI-BONE, Inc., a ... iFuse Implant System, ® a minimally invasive surgical ... joint, today announced that the U.S. Patent and Trademark ... systems and methods for the fixation and fusion of ... fenestrated implant with a tapered distal end that may be placed from ...
(Date:9/23/2014)... 23, 2014  Global Discovery Biosciences, a laboratory dedicated ... the biggest healthcare challenges, announces their collaboration with IPMD, ... test for the early detection of lung cancer. ... death. Typically, the symptoms and subsequent diagnosis of lung ... the chance of a cure has already passed. Early ...
Breaking Medicine Technology:Market Snapshot: Transcatheter Heart Valve 2007 to 2020 - Europe (Germany, France, Italy, UK, Spain) 2SI-BONE, Inc. Strengthens Patent Portfolio with the U.S. Patent and Trademark Office's Issuance of Threaded, Fenestrated Implant Method Patent 2SI-BONE, Inc. Strengthens Patent Portfolio with the U.S. Patent and Trademark Office's Issuance of Threaded, Fenestrated Implant Method Patent 3Global Discovery Biosciences Announces Collaboration with IPMD, Inc. to Develop Innovative Aptamer-Based Blood Test for the Early Detection of Lung Cancer 2
... Feb. 7, 2011 ConvaTec, a world-leading developer and ... care, today announced the appointment of several executives to ... Pionati has been appointed President, Intercontinental in a newly ... and Canada. These markets continue to be a strategic ...
... Corp. (Nasdaq: BSTC ; the "Company" or ... products, today announced that its Board of Directors has ... 14, 2002 and previously amended June 19, 2003 (the ... for determining "Acquiring Person" status under the Rights Agreement ...
Cached Medicine Technology:ConvaTec Announces New Appointments to Leadership Team 2
The Astigmatome makes precise and accurate cuts for astigmatism correction simply and safely. The procedure can be done in the office under topical anesthesia. Complete Set Includes Vacuum Speculum, ...
... Streamline family of temporary sensing and pacing ... standard in temporary pacing leads and improved ... to use and less traumatic to heart ... are designed to provide consistent temporary sensing ...
Carbo-Seal Valsalva AAP is the first valved graft to replicate the natural Sinus of Valsalva, encouraging the natural formation of systolic vortices....
Current annuloplasty rings and bands are designed for symmetric dilatation. The IMR ETlogix ring is the first asymmetric ring designed to treat asymmetric dilatation....
Medicine Products: