Navigation Links
International clinical trial tests targeted drug for melanoma
Date:11/30/2010

CHICAGO Rush University Medical Center has just enrolled the first U.S. patient in an international clinical trial testing a novel drug to treat certain kinds of melanoma, a deadly skin cancer that in its advanced stages currently has few effective treatments.

Rather than blocking or killing all rapidly dividing cells, whether malignant or not, the drug, called nilotnib, is one of a new class of agents that have been designed to sabotage aberrant molecules characteristic of individual cancers in this case, the c-kit protein.

Dr. Howard Kaufman, director of the Rush University Cancer Center and lead investigator of the study at Rush, said that this kind of "targeted" therapy holds out hope of transforming cancer from a lethal disease into a chronic, but manageable disease.

"For advanced melanoma, there are currently few satisfactory treatments," Kaufman said. "But new targeted therapies, including vaccines, antibodies and small molecules like nilotnib are in clinical trials now, adding to an arsenal of treatments that appear to be promising. This trial is especially significant since the c-kit mutation is found more commonly in melanoma arising from the mucosa and foot, which are historically very difficult types of melanoma to treat."

Nilotnib, marketed by Novartis under the brand name Tasigna, is an oral drug approved by the Food and Drug Administration for the treatment of chronic myelogenous leukemia but is now being tested for the first time for the treatment of melanomas that express the c-kit gene. As a small molecule, nilotnib is able to slip across the cell's membrane and into the machinery inside. There it targets, and turns off, the abnormal c-kit protein, created by a mutated c-kit gene, shutting it down and thus disrupting the relay team of molecular signals the protein participates in that ultimately spur cell growth and cause melanoma lesions to proliferate.

Patients with melanomas expressing a mutated c-kit gene are eligible to participate in the study. These types of melanomas, which typically occur in mucosal tissue, the eye or the foot, are extremely aggressive. The aim of the trial is to determine whether nilotnib can block the growth and spread of this kind of melanoma and extend life.

Participants will receive either nilotnib or dacarbazine, a chemotherapy drug commonly used to treat advanced melanoma. Those in the latter group will be able to begin receiving nilotnib if their cancer progresses after dacarbzaine treatment.

Melanoma is a rare but deadly disease whose incidence is rising faster than that of any other solid tumor. According to the National Cancer Institute, there were 68,700 new cases of melanoma in 2009, and more than 8,500 deaths caused by the disease. The cancer typically begins in a mole, but can also lodge in other pigmented tissues, such as in the eye or in the intestines. If caught early, when the disease is superficial, the lesions can easily be removed surgically. But if it advances, the prognosis is poor. Median survival is six months to two years.


'/>"/>

Contact: Sharon Butler
Sharon_Butler@rush.edu
312-942-7816
Rush University Medical Center
Source:Eurekalert

Related medicine news :

1. International Diabetes Federation awards $2 million to 9 global diabetes research projects
2. Jion Beijing Great Wall International Travel Agency Immediate Exposure to China Expo 2010
3. H1N1 international symposium to be hosted by Emory-UGA Influenza Center
4. International Insurance Group, Inc. Releases First Quarter 2010 Newsletters
5. Partners Harvard Medical International Set to Play Key Role as Saudi Arabia Pursues Ambitious Health Care Transformation
6. The Hawaii Nurses Association Announces Affiliation with the Office and Professional Employees International Union, AFL-CIO
7. Reno Children With Disabilities Profit From a Little Known but Internationally Recognized Non-Profit Organization as it Quietly Crosses the $200,000.00 Mark in Service Investment Into the Reno Area
8. Tyco International Announces Exchange Rate for Quarterly Dividend
9. International Merchant Advisors Inc. to Open New Wellness Centers With Medical Marijuana Treatment Facilities
10. SRI International Expands Neurosciences Research with New Neurodegenerative Diseases Research Program
11. International study confirms doubling of childhood leukemia rates in southern Iraq
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... 2016 , ... The Global Wellness Summit (GWS), an annual conference ... of wellness, travel, spa and beauty in Europe. The organization asked its partner experts ... economists and researchers - to forecast where wellness is headed in Europe. Predictions range ...
(Date:5/31/2016)... ... May 31, 2016 , ... The Orthopaedic Research and Education Foundation (OREF) is ... G. Lewallen, MD, began his term as president in March, succeeding John J. Callaghan, ... OREF’s new president-elect. Richard F. Kyle, MD, will serve as chair, corporate development, succeeding ...
(Date:5/31/2016)... ... May 31, 2016 , ... In a recent interview on The Greenburgh ... New Rochelle, NY-based WVOX (1460 AM), leading medical insurance advocate Adria Goldman ... country’s “modern medical money maelstrom.” , During the interview with Mr. Feiner that ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... ... to apply information technology solutions to the healthcare industry, The University of Scranton ... program offers an accelerated path to a career in rapidly growing field of ...
(Date:5/30/2016)... (PRWEB) , ... May 30, 2016 , ... ... to use inside of FCPX," said Christina Austin - CEO of Pixel Film ... for use within Final Cut Pro X. Choose from abstract transitions to more ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 ... instances of hypertension is driving ambulatory blood pressure monitoring ... their elasticity and their ability to respond to different ... This condition can lead to various cardiovascular disorders such ... vascular disease. These diseases are growing in prevalence each ...
(Date:5/27/2016)... 27, 2016 The healthcare sector ... insurance companies all falling under its umbrella.  A rather ... not often talked about, these healthcare companies are still ... is by far the largest consumer of ... Corp. (OTC: ADMD), Nutranomics Inc. (OTC: NNRX), KollagenX Corp. ...
(Date:5/26/2016)... Tenn. , May 26, 2016 /PRNewswire/ ... of software and analytics, network solutions and ... today announced it entered into a strategic ... provider of outpatient software solutions and revenue ... centers, specialty hospitals and rehabilitation clinics to ...
Breaking Medicine Technology: