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International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
Date:7/1/2009

, the Molecular Genetics of Schizophrenia (MGS). The MGS publication is entitled “Common variants on chromosome 6p22.1 are associated with schizophrenia.

Each study analyzed several thousand individuals with hundreds of thousands genetic markers distributed along the human genome, conducted the statistical analysis of their sample, and then shared data of their top results for a meta-analysis. The three samples combined comprised over 8,000 schizophrenia cases and over 19,000 control samples of European ancestry. “The combined analysis of the three datasets highlighted a region in chromosome 6p22.1 that is associated with schizophrenia," said Dr. Gejman.

The 6p22.1 region includes a histone gene cluster (protein “spools” around which DNA wraps and affect the degree to which genes are turned on and off) and multiple immunity-related genes, suggesting a variety of possible pathophysiological mechanisms in schizophrenia, from abnormal transcriptional regulation to autoimmunity and maternal infections.
Dr. Gejman said, “These studies show that there are common variants increasing risk for schizophrenia, albeit representing small individual effects, and suggest that even larger samples may succeed in uncovering additional variants of pathophysiological importance, further illuminating the mechanisms of this devastating illness.”

Dr. Alan R. Sanders, a collaborator at NorthShore, states, “Schizophrenia is largely a genetic disease, though a complex one, and people who have close family members wit
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International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
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