Navigation Links
International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
Date:7/1/2009

The July 1, 2009 advance online edition of the journal Nature includes three companion papers describing the results of genome-wide association studies (GWAS) of schizophrenia. Schizophrenia is an elusive and severe psychiatric disorder that affects up to 70 million people worldwide. The causes of schizophrenia remain largely unknown and there is no cure, though for some individuals the current treatments work well. There are multiple factors that increase the risk for schizophrenia, of which genetic factors are the most prominent, though not precisely identified yet. This highlights the need for a better understanding of the pathways leading to schizophrenia to enable development of better treatments.

Evanston, IL (Vocus) July 1, 2009 -- The July 1, 2009 advance online edition of the journal Nature includes three companion papers describing the results of genome-wide association studies (GWAS) of schizophrenia. Schizophrenia is an elusive and severe psychiatric disorder that affects up to 70 million people worldwide. The causes of schizophrenia remain largely unknown and there is no cure, though for some individuals the current treatments work well. There are multiple factors that increase the risk for schizophrenia, of which genetic factors are the most prominent, though not precisely identified yet. This highlights the need for a better understanding of the pathways leading to schizophrenia to enable development of better treatments.

Dr. Pablo Gejman, Director of the NorthShore University HealthSystem (NorthShore) Center for Psychiatric Genetics, led one of these three international collaborations, the Molecular Genetics of Schizophrenia (MGS). The MGS publication is entitled “Common variants on chromosome 6p22.1 are associated with schizophrenia.

Each study analyzed several thousand individuals with hundreds of thousands genetic markers distributed along the human genome, conducted the statistical analysis of their sample, and then shared data of their top results for a meta-analysis. The three samples combined comprised over 8,000 schizophrenia cases and over 19,000 control samples of European ancestry. “The combined analysis of the three datasets highlighted a region in chromosome 6p22.1 that is associated with schizophrenia," said Dr. Gejman.

The 6p22.1 region includes a histone gene cluster (protein “spools” around which DNA wraps and affect the degree to which genes are turned on and off) and multiple immunity-related genes, suggesting a variety of possible pathophysiological mechanisms in schizophrenia, from abnormal transcriptional regulation to autoimmunity and maternal infections.
Dr. Gejman said, “These studies show that there are common variants increasing risk for schizophrenia, albeit representing small individual effects, and suggest that even larger samples may succeed in uncovering additional variants of pathophysiological importance, further illuminating the mechanisms of this devastating illness.”

Dr. Alan R. Sanders, a collaborator at NorthShore, states, “Schizophrenia is largely a genetic disease, though a complex one, and people who have close family members with schizophrenia are somewhat more likely to get this chronic, debilitating brain disorder. It usually begins in adolescence or early adulthood, and is characterized by hallucinations, delusions, disorganized thinking and behavior, and loss of interest and initiative. Chronic impairment in social functioning remains the more prevalent disease course, even with treatment.” Dr. Sanders further noted that, “Unlike the European ancestry only samples of the companion papers, the MGS sample also includes an African American (AA) subsample comprised by over 2,200 individuals. The AA GWAS results supported previously reported schizophrenia associations for the genes, ERBB4 on chromosome 2q34 and its ligand, neuregulin (NRG1 on chromosome 8p12).

The NorthShore team expects to continue to generate knowledge aimed at this goal of better therapeutics, such as more specific and effective medications with fewer side effects.
The studies were led, respectively, by Drs. Pablo V. Gejman of NorthShore University HealthSystem (MGS, the Molecular Genetics of Schizophrenia collaboration), Pamela Sklar of the Broad Institute (ISC, the International Schizophrenia Consortium), and Kari Stefansson of deCODE Genetics (SGENE, the Schizophrenia Gene consortium).

The MGS study was supported by the National Institute of Mental Health (multiple grants), the Paul Michael Donovan Charitable Foundation, NorthShore University HealthSystem the National Alliance for Research on Schizophrenia and Depression, the Genetic Association Information Network (GAIN, and the National Center for Research Resources

About NorthShore University HealthSystem
Located in Chicago's northern suburbs, NorthShore University HealthSystem (formerly Evanston Northwestern Healthcare) is an academic health system affiliated with the University of Chicago’s Pritzker School of Medicine. Our integrated delivery system includes Evanston (founded in 1891), Glenbrook, Highland Park, and Skokie Hospitals as well as the NorthShore Medical Group, Research Institute, and Foundation. NorthShore has annual revenues of $1.5 billion and a staff of more than 8,000. The fully integrated health system has significant capabilities in a wide spectrum of clinical programs, including cancer, heart, orthopedics, high-risk maternity, and pediatrics. NorthShore is a national leader in the implementation of innovative technologies, including electronic medical records.

CONTACT:
Rikki Ragland
Director, Public Relations
(847) 570-3144
rragland @ northshore.org

###

Read the full story at http://www.prweb.com/releases/NorthShore/Schizophrenia/prweb2589764.htm.


'/>"/>
Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Christian Childrens Fund Name Change to ChildFund International Official
2. AIUM announces management agreement with the International Society of Therapeutic Ultrasound
3. Intelligent Hospital Systems Receives International Award for Innovative Technology Benefiting Society
4. Jackson International Launches New Website in Collaboration with Medicaview International
5. Kiwanis International Pursuing Second Worldwide Service Project
6. Internationally Renowned Orthopaedic Surgeon, Giancarlo Puddu, MD, Inducted into Sports Medicine Hall of Fame
7. Misonix Announces Participation in 2nd International Workshop on Focal Therapy
8. Multivu Video Feed: JDRF International Chairman Mary Tyler Moore Testifies on the Need for Federal Funding for Type 1 Diabetes Research
9. Validation & Compliance Institute, LLC, to Provide Dietary Supplement GMP Training for NSF International
10. Milestone Scientific Expands Global Sales Strategy to Enhance Penetration of International Dental Markets
11. Internationally-Renowned Health and Wellness Authority Joins livethesource(TM) as a Master Distributor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/13/2017)... 13, 2017   OrthoAtlanta has been named the ... Host Committee (AFHC) for the 2018 College Football Playoff (CFP) ... at Mercedes-Benz Stadium in Atlanta, Georgia . ... "I,m In" campaign, participating in many activities leading up to, ... ...
Breaking Medicine Technology: