Navigation Links
Interferon needed for cells to 'remember' how to defeat a virus, UT Southwestern researchers report
Date:12/2/2008

DALLAS Dec. 3, 2008 Scientists at UT Southwestern Medical Center have determined that the immune-system protein interferon plays a key role in "teaching" the immune system how to fight off repeated infections of the same virus.

The findings, available online and in the Dec. 15 issue of the Journal of Immunology, have potential application in the development of more effective vaccines and anti-viral therapies.

Typically, when a person is infected with a virus, the human body immediately generates a massive number of T cells a type of immune cell that kill off the infected cells. Once the infection has cleared, most of the T cells also die off, leaving behind a small pool of central memory cells that "remember" how to fight that particular type of virus if the person is infected again.

"In this study, we have uncovered interferon's role and the key signaling protein, called IL-2, involved in generating memory T cells," said Dr. David Farrar, assistant professor of immunology at UT Southwestern and senior author of the study. "Knowing how T cells acquire this memory may help us design better strategies and vaccines to fight HIV and other infectious diseases. Further, our discovery was made using primary human CD4+ T cells, which underscores the relevance of our discovery to human immune responses."

CD4+ T cells coordinate the actions of other cells at the site of infection.

When a virus or bacterium infects a human, the infected cells secrete several molecules, including a cytokine or signaling protein called interferon alpha. The action of interferon is what makes an infected person feel run down and tired. Although scientists knew that interferon alpha prevented a virus from multiplying and spreading, they didn't know what role interferon played in the creation of memory cells.

In the current study, the UT Southwestern researchers show that both interferon alpha and another signaling protein called IL-12 are needed to induce the creation of memory cells. They found that interferon and IL-12 team up to promote the creation of a special set of cells that then secrete another signaling protein called IL-2. These IL-2-secreting cells are the ones that remain in the body and "remember" how to fight off the virus.

"Without the IL-2 signaling protein, you'll generate a beautiful primary response against a virus, and you'll eliminate the bug, but your body won't remember how it defeated the virus," Dr. Farrar said. "Without these memory cells, your body is defenseless against re-infections."

Ann Davis, student research assistant in immunology and lead author of the study, said this suggests a new role for interferon: teacher.

"This is really the first demonstration of a role for interferon in teaching a T cell how to respond to viral infections," she said.

Dr. Farrar added: "Up until now, interferon has always been appreciated for its role in inhibiting virus infections. But no one's really paid attention to interferon and its role in regulating memory. That's why we're so excited about this result."

The next step, Dr. Farrar said, is to complete the same study in mice. Early results show that mice with T cells that can't respond to interferon are unable to protect themselves when a virus invades.

"Their immune systems have no idea how to fight the virus," Dr. Farrar said. Dr. Farrar said these early findings in mice may pave the way for designing more effective vaccines.


'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related medicine news :

1. Only Half of MS Patients Respond to Interferon Therapy
2. Interferon Reduces, Eliminates Viral Infections in Heart Failure Patients
3. Study shows that high-dose, high-frequency interferon produces no additional benefit
4. GenOdyssee Receives Notice of Allowance from U.S. Patent Office for Improved Interferon-Alpha Aimed at Hepatitis C
5. PEGINTRON(TM) and REBETOL(R) Approved in European Union for Retreating Hepatitis C Patients Who Failed Previous Pegylated or Non-Pegylated Interferon Therapy
6. Interferon does not slow or stop hepatitis C from worsening, study finds
7. Revised hours and workloads for medical residents needed to prevent
8. New survey: More than half of US chronically ill adults skip needed care due to costs
9. EMU School of Nursing Injects Much Needed Help Into Nursing Shortage
10. MSU doctors bring much-needed psychiatric care to rural areas via technology
11. Susan G. Komen for the Cure(R), Speaker Dennis OBrien, Obama and McCain Health Care Advisors, Breast Cancer Survivors and Advocates Call for Needed Health Care Reforms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Interferon needed for cells to 'remember' how to defeat a virus, UT Southwestern researchers report
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/26/2016)... ... , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... a whole new perspective by using the title layers in ProSlice Levels to ... ProSlice Levels contains over 30 Different presets to choose from. FCPX users ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
(Date:6/23/2016)... WAYNE, Pa. , June 23, 2016 ... provider, will launch its next generation clinical outcomes platform, Bracket ... DIA Meeting held on June 26 – 30, 2016 in ... 6.0, the first electronic Clinical Outcome Assessment product of its ... DIA Booth #715. Bracket eCOA 6.0 is a ...
(Date:6/23/2016)... June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations ... Latin America . ... ... ... ...
Breaking Medicine Technology: