Navigation Links
Interferon needed for cells to 'remember' how to defeat a virus, UT Southwestern researchers report
Date:12/2/2008

DALLAS Dec. 3, 2008 Scientists at UT Southwestern Medical Center have determined that the immune-system protein interferon plays a key role in "teaching" the immune system how to fight off repeated infections of the same virus.

The findings, available online and in the Dec. 15 issue of the Journal of Immunology, have potential application in the development of more effective vaccines and anti-viral therapies.

Typically, when a person is infected with a virus, the human body immediately generates a massive number of T cells a type of immune cell that kill off the infected cells. Once the infection has cleared, most of the T cells also die off, leaving behind a small pool of central memory cells that "remember" how to fight that particular type of virus if the person is infected again.

"In this study, we have uncovered interferon's role and the key signaling protein, called IL-2, involved in generating memory T cells," said Dr. David Farrar, assistant professor of immunology at UT Southwestern and senior author of the study. "Knowing how T cells acquire this memory may help us design better strategies and vaccines to fight HIV and other infectious diseases. Further, our discovery was made using primary human CD4+ T cells, which underscores the relevance of our discovery to human immune responses."

CD4+ T cells coordinate the actions of other cells at the site of infection.

When a virus or bacterium infects a human, the infected cells secrete several molecules, including a cytokine or signaling protein called interferon alpha. The action of interferon is what makes an infected person feel run down and tired. Although scientists knew that interferon alpha prevented a virus from multiplying and spreading, they didn't know what role interferon played in the creation of memory cells.

In the current study, the UT Southwestern researchers show that both interferon alpha and another signaling protein called IL-12 are needed to induce the creation of memory cells. They found that interferon and IL-12 team up to promote the creation of a special set of cells that then secrete another signaling protein called IL-2. These IL-2-secreting cells are the ones that remain in the body and "remember" how to fight off the virus.

"Without the IL-2 signaling protein, you'll generate a beautiful primary response against a virus, and you'll eliminate the bug, but your body won't remember how it defeated the virus," Dr. Farrar said. "Without these memory cells, your body is defenseless against re-infections."

Ann Davis, student research assistant in immunology and lead author of the study, said this suggests a new role for interferon: teacher.

"This is really the first demonstration of a role for interferon in teaching a T cell how to respond to viral infections," she said.

Dr. Farrar added: "Up until now, interferon has always been appreciated for its role in inhibiting virus infections. But no one's really paid attention to interferon and its role in regulating memory. That's why we're so excited about this result."

The next step, Dr. Farrar said, is to complete the same study in mice. Early results show that mice with T cells that can't respond to interferon are unable to protect themselves when a virus invades.

"Their immune systems have no idea how to fight the virus," Dr. Farrar said. Dr. Farrar said these early findings in mice may pave the way for designing more effective vaccines.


'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related medicine news :

1. Only Half of MS Patients Respond to Interferon Therapy
2. Interferon Reduces, Eliminates Viral Infections in Heart Failure Patients
3. Study shows that high-dose, high-frequency interferon produces no additional benefit
4. GenOdyssee Receives Notice of Allowance from U.S. Patent Office for Improved Interferon-Alpha Aimed at Hepatitis C
5. PEGINTRON(TM) and REBETOL(R) Approved in European Union for Retreating Hepatitis C Patients Who Failed Previous Pegylated or Non-Pegylated Interferon Therapy
6. Interferon does not slow or stop hepatitis C from worsening, study finds
7. Revised hours and workloads for medical residents needed to prevent
8. New survey: More than half of US chronically ill adults skip needed care due to costs
9. EMU School of Nursing Injects Much Needed Help Into Nursing Shortage
10. MSU doctors bring much-needed psychiatric care to rural areas via technology
11. Susan G. Komen for the Cure(R), Speaker Dennis OBrien, Obama and McCain Health Care Advisors, Breast Cancer Survivors and Advocates Call for Needed Health Care Reforms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Interferon needed for cells to 'remember' how to defeat a virus, UT Southwestern researchers report
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced ... attorneys chosen by their peers for this recognition are considered among the top 2 ... received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: