Interferon does not slow or halt the progression of chronic hepatitis C and advanced liver disease in patients who havent responded to previous attempts to eradicate the disease, a national study in which the Saint Louis University School of Medicine participated has found.
Patients in the trial who were treated with interferon did experience a significant decrease in viral levels and liver inflammation, but the trial unequivocally demonstrated that treatment with long-term pegylated interferon also called peginterferon does not prevent the worsening of liver disease in patients whove failed prior treatments.
The results are this study are very clear long-term therapy with peginterferon for those with chronic hepatitis C is not effective in preventing progression of liver disease for patients who did not respond to an initial course of treatment, said Adrian Di Bisceglie, M.D., professor of internal medicine at Saint Louis University School of Medicine and chairman of the trials steering committee.
Furthermore, the relatively high rate of liver disease progression about 30 percent over nearly four years indicates the potential severity of chronic hepatitis C and emphasizes the importance of the ongoing search for new and more effective treatments, Di Bisceglie added.
Results of the study were reported by Di Bisceglie at the annual meeting of the American Association for the Study of Liver Disease in Boston this week.
Hepatitis C infects more than 100 million people worldwide and as many as 4 million people in the U.S. It ranks with alcohol abuse as the most common cause of chronic liver disease and leads to some 1,000 liver transplants in the U.S. each year.
The randomized, multi-site study involved 1,050 patients with chronic hepatitis C whod failed prior treatments to eradicate the infection. All had advanced liver fibrosis a gradual scarring of the liver that puts patients at risk for progress
|Contact: Donn Walker|
Saint Louis University