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Interferon Reduces, Eliminates Viral Infections in Heart Failure Patients
Date:11/11/2008

ted as responders. This resulted in clearance rates of 40 percent and 50 percent in the chronic adenovirus-enterovirus group, depending on the dose, and clearance or reduction rates of 31.8 percent to 35.7 percent in the parvovirus group, Schultheiss said.

Secondary endpoints included change in NYHA functional class; performance on a six-minute walk test; individual clinical symptoms; quality of life and echocardiographic left ventricular ejection fraction (LVEF) -- a measure of the heart's ability to pump blood -- both at rest and on exertion; and several other measures of heart function and inflammation. No significant changes in these were reported at 24 weeks after treatment, although there were trends toward improvement.

Co-authors are: Cornelia Piper, M.D., Ph.D.; Olaf Sowade, M.D.; Kristjan Karason, M.D., Ph.D.; Joachim-Friedrich Kapp, M.D., Ph.D.; Karl Wegscheider, Ph.D., M.Sc.; Georg Groetzbach, M.D.; Finn Waagstein, M.D., Ph.D.; Eloisa Arbustini, M.D.; Harald Siedentop, Ph.D.; and Uwe Kuehl, M.D., Ph.D. Individual author disclosures can be found on the abstract.

The study was funded by Bayer Health Care.

Statements and conclusions of study authors that are presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.americanheart.org/corporatefunding.


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SOURCE American Heart Association
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