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Interesting stories at the IMPAKT Breast Cancer Conference
Date:5/7/2010

breast cancer? The sodium-iodide symporter
N. Fortunati, ITALY,
The sodium-iodide symporter (NIS) mediates iodide uptake into thyroid cells allowing radioiodine imaging and therapy in thyroid cancer. NIS is also expressed in lactating mammary glands, and in more than 80% of human breast carcinomas. This study reports that the pan-deacetylase (DAC) inhibitor LBH589 induces NIS expression and function in breast cancer cultured cells. LBH589 appears to be an interesting compound in the managing of breast cancer, giving the opportunity of using radioiodide as further diagnostic and therapeutic tool.

Abstract 143P: Combination of ASA404 (vadimezan) with paclitaxel and trastuzumab
D.B. Evans, SWITZERLAND
ASA404 is a flavonoid, non tubulin-binding Tumour-Vascular Disrupting Agent that induces breakdown of the established tumor vasculature and hence inhibition of the tumor blood supply, leading to ischemia and extensive necrosis of the tumor core. This study shows that it enhances the activity of trastuzumab and paclitaxel, highlighting the potential value of this combination in breast cancer treatment.

Abstract 105P: Overcoming trastuzumab resistance?
M. Gijsen, UNITED KINGDOM.
It is still poorly understood how trastuzumab exerts its tumor inhibition effect. Its acquired resistance mechanisms are also not yet fully determined. This study provides evidence that trastuzumab resistance can be mediated by activation of HER family ligands as a result of a PKB negative feedback loop. This offers treatment opportunities for overcoming resistance in these patients, including approaches to target all HER receptors in combination with trastuzumab treatment.


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Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

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