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Interesting stories at the IMPAKT Breast Cancer Conference
Date:5/7/2010

s model in a cohort of pts with long term follow-up is underway.

Abstract 36P: Assessment of circulating tumor cells (CTCS) in blood of primary invasive duct carcinoma (PIDC) patients
A.A. Bahnassy, EGYPT
Prognosis of breast cancer patients is still limited by the occurrence of distant metastases. 1) Detection and monitoring of CTCs in blood is an easy, non-invasive procedure enabling repeated analyses. 2) Flow-cytometry provides a simple and accurate technique for enumerating CTCs in peripheral blood. 3) The presence of CTCs in the blood of PIDC patients can predict prognosis.

Abstract 72P: Patterns of care in elderly breast cancer patients
A. Mahipal, UNITED STATES OF AMERICA,
Elderly breast cancer (age 65 years or more) patients are underrepresented in most of clinical trials. This study suggests that the proportion of elderly patients receiving chemotherapy is increasing in recent years. Elderly patients who received chemotherapy had better clinical outcomes than those who did not. Age should not be a sole factor in determining chemotherapy administration.

Abstract 142P: New drug candidate? Synthetic analogues of flavaglines
L. Dsaubry, FRANCE
Flavaglines are a family of natural compounds. This study suggests that flavaglines are a novel class of molecules that selectively induce the death of cancer cells independently of the classical apoptosis pathways, and do not display any sign of toxicity in vivo.

Abstract 67P: Gene differences predict survival outcomes after chemotherapy in breast cancer patients
E. Castro Marcos, SPAIN
Single nucleotide polymorphisms SNPs in genes XRCC3 and XRCC1 are associated with different outcomes, likely attributable to the differential abilities to repair anthracycline-induced DNA damage. These promising findings have pharmacogenomics implications in matching particular adjuvant CT for specific cancer patients.

Abstract 140P: New target for
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Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

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