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Interesting stories at the IMPAKT Breast Cancer Conference
Date:5/7/2010

Abstract 35P: Markers for risk of pregnancy-associated breast cancer
C.B. Agborsangaya, FINLAND
As women delay child-birth to the third and fourth decades, the incidence of pregnancy-associated breast cancer is expected to rise. This paper suggests that identification of p53 autoantibody-positive pregnant women may be useful in predicting outbreak or early detection of pregnancy-associated breast cancer.

Abstract 92P: Post traumatic stress disorder in breast cancer patients
E. Calbari, GREECE
Having breast cancer is not a merely stressful experience, but rather involves a cascade of unfolding threats and stressors. According to new findings, 45% of patients treated reported cancer-related PTSD and poorer quality of life even after 3 years of diagnosis and treatment.

Abstract 108P: Delivering RNA interference to HER2 overexpressing breast cancer
E. Song, CHINA
Researchers investigated the specificity and efficiency of a fusion protein against HER-2 and truncated protamine to deliver siRNAs into HER-2 expressing breast cancer cells in vitro and in vivo. The proteins can selectively deliver siRNA to HER2 overexpressing breast cancer cells in vitro and in vivo.

Abstract 102P: MicroRNAs regulate the stemness of breast tumor initiating cells
E. Song, CHINA
Researchers show that self-renewal of breast cancer stem cells are tightly regulated by microRNAs, suggesting that targeting delivery of tumor-suppressing microRNAs into breast tumor initiating cells emerges to be a novel approach for breast cancer treatment.

Abstract 27P: A fingerprint potentially correlated with the presence of micro-metastatic disease in early breast cancer
C. Oakman, ITALY,
This pilot study uses serum metabolomic profiles to discriminate between early and advanced breast cancer patients. Compared with traditional risk factors, metabolomics may identify more pts with lower relapse risk. Validation of thi
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Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

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