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Interactions between drugs can also be measured at lowest doses
Date:4/11/2013

o need to take several drugs simultaneously. Many drugs inhibit this enzyme, which metabolises around half of all regularly used medicines. However, if a drug is degraded too slowly, at normal doses, it accumulates in the body and, in the worst case, can cause toxicity.

Further studies planned

Prof. Haefeli and his team are now testing the new method in patients. "Since we can use minimal drug doses, these studies are also safe for patients," Prof. Haefeli explained. Heidelberg University pharmacologists will also examine the interactions of other medications that influence other metabolic enzymes. "The method could also be used in the many studies in which interactions are relevant for approval by the authorities, for instance," said Prof. Haefeli, looking toward the future.


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Contact: Walter E. Haefeli
walter.emil.haefeli@med.uni-heidelberg.de
49-622-156-8740
Heidelberg University Hospital
Source:Eurekalert

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