Navigation Links
Interactions between drugs can also be measured at lowest doses
Date:4/11/2013

ractions in study participants. Mass spectrometers are so sensitive that they are able to identify the drug in a single drop of blood. The scientists conducted a study on interactions in 12 healthy test persons taking the fungicide ketoconazole and the sedative midazolam simultaneously. For the study, they administered midazolamdoses of 0.0000001 g, which was 30,000 times lower than the amount used for therapy. Comparisons with higher doses revealed that the drugs behaved identically at all concentrations. Therefore, even a minimal concentration in the body is sufficient to reliably predict the extent of the interaction during normal use.

Inhibition of the liver enzyme measurable in the nanogram range

With the help of ultrasensitive mass spectrometers, the speed with which a drug is degraded can be measured. They are used wherever small amounts need to be detected in liquids, e.g., contamination in drinking water, doping agents or environmental toxins. To this end, a small amount of blood or other body fluid is withdrawn after certain time intervals in order to determine the remaining concentration of the drug. The mass spectrometer sorts the molecules and determines their concentration. Based on their characteristic properties, the drugs can be reliably identified. "For the first time, we have proven that with this technique, we are able to find drugs in the blood even at extremely low doses, and that we can quantitatively determine them and identify their interactions," Prof. Haefeli said.

In the published study, the team investigated the interaction between the sedative midazolam, which is metabolized in the liver by the protein cytochrome P450 3A, and the fungicide ketoconazole, a well-known inhibitor of this cytochrome. The inhibition of the cytochrome and, in turn, the reduced degradation of midazolam, were already precisely measured in the nanogram dose. This interaction in particular plays an important role for patients wh
'/>"/>

Contact: Walter E. Haefeli
walter.emil.haefeli@med.uni-heidelberg.de
49-622-156-8740
Heidelberg University Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel technique demonstrates interactions between malaria parasite and HIV
2. Stanford/Intel study details power of new chip to diagnose disease, analyze protein interactions
3. Survey shows medical students have frequent interactions with pharmaceutical companies
4. Study finds significant skull differences between closely linked groups
5. Study: No link between depression, nasal obstruction
6. AADR comments on review that validates association between oral health and heart health
7. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
8. Study shows link between pre-pregnancy obesity and lower test scores
9. First study investigating possible link between sunscreen ingredient and endometriosis
10. Early Study Hints at Link Between Certain Sunscreens, Endometriosis
11. Understanding the links between inflammation and chronic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... ... , ... Certified Nutrition Businessman Reid Eckert agrees to extend his business relationship ... global sales and communications firm that offers U.S. brands a proven path to world ... Mr. Reid Eckert, as his interpretation of the nutritional needs of the human body ...
(Date:8/29/2015)... ... August 30, 2015 , ... Rio Salado College ... serve as the college’s Vice President of Strategic Initiatives and Information Services. O’Shea, who ... help the college expand its reach and impact through innovative technologies and strategies. , ...
(Date:8/29/2015)... PITTSBURGH, PA (PRWEB) , ... August 29, 2015 ... ... 1996," said one of two inventors from Miller Place, N.Y. "I specialize in ... pain and discomfort. In addition, it can be used for additional muscle dysfunction ...
(Date:8/29/2015)... ... ... like Toppik , Eau Thermale Avene and Bliss are now available on ... required to qualify for free standard shipping,” said Jennifer Ramirez, the public relations manager. ... the item’s selling price.” , With competitive pricing in the e-commerce market for beauty ...
(Date:8/29/2015)... ... August 29, 2015 , ... Hamstring strain have ... soft tissue manipulation. Platelet rich plasma injections also have mixed results. Building ... treatment outcomes. This localized treatment seems to address the symptoms and does ...
Breaking Medicine News(10 mins):Health News:Nutrition Guru Continues Relationship With Renowned Health and Wellness Company 2Health News:Rio Salado College Appoints New Vice President of Strategic Initiatives and Information Services 2Health News:Inventors and InventHelp Clients Develops Tension Reliever (LGI-1951) 2Health News:TheBeautyPlace.com Discounts Shipping on Select Brands 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 3
... consumers are good judges of affordability, but a new study ... by whether you think about a larger pool of resources ... cash in your wallet). Through a series of four ... food and time. Counting calories" Youre more likely to eat ...
... the University of California San Francisco has identified distinct ... is likely to develop subsequent invasive cancer after initial ... The research, published by Cell Press in the November ... be used to determine whether a woman should receive ...
... Shopko announced today the,appointment of W. Paul ... Officer. Jones will be responsible for the direction ... mass retailer. Jones, career has been highlighted ... mid-tier chain stores and big box retailers. He,has ...
... scientists,from around the world gathered for the 2007 ... The Symposium was,hosted by the Ringling Bros. and ... International Elephant Foundation (IEF), and was,held in conjunction ... Research. The Conference brought together experts in human ...
... releases nationwide eValue8,findings, SCOTTSDALE, Ariz., Nov. ... of health plan performance released today by ... health plans could do a,better job of ... in patient safety, care coordination, consumer selection ...
... Barry McMillen - Nicotine Cessation Expert and ... ... Using tobacco isn,t just a,habit; it,s an addiction. Hazelden has been ... years. The same principles,of the Hazelden treatment experience help tobacco users ...
Cached Medicine News:Health News:Big ticket: You'll spend more thinking about your bank account than about your wallet 2Health News:Biomarkers predict risk for invasive breast cancer years before the tumor develops 2Health News:Conference on Elephant Tuberculosis Research Establishes Action Plan at International Symposium on Elephant Conservation 2Health News:Conference on Elephant Tuberculosis Research Establishes Action Plan at International Symposium on Elephant Conservation 3Health News:Conference on Elephant Tuberculosis Research Establishes Action Plan at International Symposium on Elephant Conservation 4Health News:National Survey Finds Employers are Challenging Health Plans to Better Use Resources to Prevent Illness and Improve Patient Safety 2Health News:National Survey Finds Employers are Challenging Health Plans to Better Use Resources to Prevent Illness and Improve Patient Safety 3Health News:National Survey Finds Employers are Challenging Health Plans to Better Use Resources to Prevent Illness and Improve Patient Safety 4Health News:Quit Smoking Tips For The Great American Smokeout Day - November 15 2
(Date:8/28/2015)... , August 28, 2015 According ... by Tumor (Breast, Lung, Prostate) Type (Protein & Genetic ... Drug Discovery, Prognostic) & Geography - Global Forecast to ... expected to reach around 17,689.0 Million USD by 2020 ... of 2015 to 2020. Browse 191 ...
(Date:8/28/2015)... -- Research and Markets ( ... "12th Annual Report and Survey of Biopharmaceutical ... offering. The 2015 12th Annual Report ... is the most recent study of biotherapeutic developers ... capacity and production. The report contains the industry,s ...
(Date:8/28/2015)... 28, 2015 Patterson Medical, formerly the ... PDCO ), is now an independent company with ... Patterson Medical by Madison Dearborn Partners (MDP).  ... for a transition period before rebranding as the ... medicine products.  With the focused resources and expertise ...
Breaking Medicine Technology:Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 2Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 3Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 4Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 512th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 3
... BRUNSWICK, N.J. and LEIDEN, Netherlands, Feb. 8, 2011 Johnson ... (NYSE Euronext, Nasdaq: CRXL ; Swiss Exchange: CRX) ... Crucell. Reference is made to the joint press ... 8 December 2010 announcing the recommended cash offer by Johnson ...
... County Hospital is moving its computerization initiatives forward ... ChartAccess® Comprehensive EHR, the 20-bed hospital is planning ... requirements as stipulated under the American Recovery and ... same time, the Ness City, Kan.-based provider continues ...
Cached Medicine Technology:Crucell Shareholders Adopt Offer Governance Resolutions and Johnson & Johnson Makes Announcement on U.S. Regulatory Matters 2Crucell Shareholders Adopt Offer Governance Resolutions and Johnson & Johnson Makes Announcement on U.S. Regulatory Matters 3Crucell Shareholders Adopt Offer Governance Resolutions and Johnson & Johnson Makes Announcement on U.S. Regulatory Matters 4Crucell Shareholders Adopt Offer Governance Resolutions and Johnson & Johnson Makes Announcement on U.S. Regulatory Matters 5Crucell Shareholders Adopt Offer Governance Resolutions and Johnson & Johnson Makes Announcement on U.S. Regulatory Matters 6Crucell Shareholders Adopt Offer Governance Resolutions and Johnson & Johnson Makes Announcement on U.S. Regulatory Matters 7Ness County Hospital Selects ChartAccess® Comprehensive EHR from Prognosis Health Information Systems 2Ness County Hospital Selects ChartAccess® Comprehensive EHR from Prognosis Health Information Systems 3
Introducing the Guidant HEARTSTRING Proximal Seal System. A surgically intuitive system that meets the challenge of clampless hemostasis with a design that is elegant in its simplicity and profound i...
... ophthalmic Nd: YAG laser YC-1600 is a ... superb versatility and clinical performance., ,Key Features, ... Lightweight Model ,Further weight reduction has ... in your office.,, Aiming Beam Rotation ...
... Given system, developed by Given Imaging of Israel, ... of a grape. Weighing in at only four ... 4 LED lights, battery and radio transmitter coated ... to digestive enzymes. Internal gastric images are transmitted ...
... pH Monitoring System is revolutionizing ... done. Bravo allows patients to ... activities during pH testing. And ... added convenience for patients allows ...
Medicine Products: