Navigation Links
Intensive cholesterol therapy with multiple drugs effective over long term
Date:6/25/2012

MAYWOOD, Ill. - For the first time, a study has found that intensive cholesterol therapy involving a combination of drugs for 20 years may be more effective over the long run than taking a single statin medication.

Loyola University Health System cardiologist Binh An P. Phan, MD, FACC, is lead author of the study, which he presented at the National Lipid Association 2012 Annual Scientific Sessions. Phan is director of Loyola's Preventive Cardiology & Lipid Program.

Previous studies have documented the short-term benefits of taking a combination of two or three cholesterol drugs aimed at aggressively lowering LDL (bad cholesterol) and raising HDL (good cholesterol). The new study is the first to show such benefits are maintained over a period of 20 years.

Compared with patients who took a single statin, patients who received a combination-drug therapy had dramatically lower levels of LDL and triglycerides, higher HDL and less fatty buildup in the carotid artery.

At the start of the study, both groups had a similar age and fatty buildup in their blood vessels. After 20 years, the group taking the combination therapy had a "vascular age" that was 10.2 years younger than the group taking a single statin.

Vascular age reflects how old an individual's blood vessels appear to be, based on risk factors and the amount of plaque buildup; it can be higher or lower than an individual's chronological age. In the single-medication group, the average vascular age at the end of the study was 84, or 20 years older than the patients' average chronological age. In the intensive therapy group, the vascular age was 74, only 7 years older than the average chronological age.

Phan and colleagues examined data from the Familial Atherosclerosis Treatment Study (FATS). The study divided patients with extremely high cholesterol into three groups: One group took the statin medication lovastatin (Mevacor) plus a medication called colestipol that binds to cholesterol. A second group took colestipol plus niacin. A third group took a placebo.

At the time of the FATS trial, lovastatin and other statins were still unproven. Statins have since become standard therapy to lower cholesterol. They work by blocking a chemical in the liver needed to make cholesterol.

Upon completion of the initial phase of FATS, some patients agreed to continue to be followed in an observational study, which lasted for 20 years.

In this observational study, one group received a single statin and the other group received intensive combination therapy. For the first 11 years, the intensive therapy consisted of lovastatin, niacin and colestipol. After 11 years, the regimen was changed to either lovastatin or simvastatin (Zocor), plus niacin. By the end of the study, 43 patients in the intensive therapy group were still being followed, and 26 patients in the single-medication group were still being followed.

After 20 years, the intensive therapy group had a LDL cholesterol level of 85 milligrams per deciliter, while the single-medication group had an LDL level of 103 mg/dL. The intensive therapy group also had lower levels of triglycerides (116 mg/dL vs. 167) and higher levels of good HDL (56 mg/dL vs. 46).

Researchers conducted an ultrasound exam to measure fatty buildup in the carotid artery, called carotid intima-media thickness (CIMT). The CIMT was 17 percent thicker in the single-medication group than in the intensive combination therapy group (1.056 mm vs. 0.902 mm). Researchers used this finding to calculate that the single-medication group ended the study with a much higher vascular age.

"These findings are the first to illustrate the benefits of long-term intensive combination lipid [cholesterol] therapy for 20 years in patients with atherosclerotic disease," Phan and colleagues wrote.


'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. VCU researchers identify changes in cholesterol metabolic pathways
2. Cholesterol Levels Vary Widely by Country: Study
3. Eliminating the good cholesterol receptor may fight breast cancer
4. U.S.A. Hurdle Specialist Kellie Wells has Joined Elite Athletes Tiger Woods, Hines Ward and Takaishi Saito in Using Cell Therapy
5. HCRI Recognized as Center of Innovation for Stuttering Therapy
6. New drugs, new ways to target androgens in prostate cancer therapy
7. RLIP76 contributes to pancreatic cancer cell resistance to chemotherapy and radiation
8. Anti-cocaine vaccine described in Human Gene Therapy Journal
9. Pediatric regime of chemotherapy proves more effective for young adults
10. Chemotherapy effective for patients with resected SCLC or large-cell neuroendocrine carcinoma
11. Quality of life study shows stereotactic ablative radiotherapy effective treatment; stage I NSCLC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... HORSHAM, Pa. , Sept. 22, 2017 ... received a complete response letter from the U.S. Food ... (BLA) seeking approval of sirukumab for the treatment of ... response letter indicates additional clinical data are needed to ... of moderately to severely active RA. ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017 ... performance ratings for global supply chains, has published the first annual edition ... CSR performance of more than 20,400 companies evaluated by EcoVadis, based on ... 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
Breaking Medicine Technology: