Navigation Links
Intensive blood sugar treatment in trial of diabetes and cardiovascular disease changed
Date:2/6/2008

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has stopped one treatment within a large, ongoing North American clinical trial of diabetes and cardiovascular disease 18 months early due to safety concerns after review of available data, although the study will continue.

In this trial of adults with type 2 diabetes at especially high risk for heart attack and stroke, the medical strategy to intensively lower blood glucose (sugar) below current recommendations increased the risk of death compared with a less-intensive standard treatment strategy. Study participants receiving intensive blood glucose lowering treatment will now receive the less-intensive standard treatment.

The ACCORD (Action to Control Cardiovascular Risk in Diabetes) study enrolled 10,251 participants. Of these, 257 in the intensive treatment group have died, compared with 203 within the standard treatment group. This is a difference of 54 deaths, or 3 per 1,000 participants each year, over an average of almost four years of treatment. The death rates in both groups were lower than seen in similar populations in other studies.

A thorough review of the data shows that the medical treatment strategy of intensively reducing blood sugar below current clinical guidelines causes harm in these especially high-risk patients with type 2 diabetes, said Elizabeth G. Nabel, M.D., director, NHLBI. Though we have stopped this part of the trial, we will continue to care for these participants, who now will receive the less-intensive standard treatment. In addition, we will continue to monitor the health of all participants, seek the underlying causes for this finding, and carry on with other important research within ACCORD.

In stopping this part of the trial, Nabel accepted the recommendation of the 10-member Data and Safety Monitoring Board (DSMB) an independent advisory group of experts in diabetes, cardiovascular disease, ep
'/>"/>

Contact: NHLBI Communications Office
NHLBI_news@nhlbi.nih.gov
301-496-4236
NIH/National Heart, Lung and Blood Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Susan G. Komen for the Cure Sharing Grassroots Advocacy Knowledge With International Representatives in Intensive Dallas Training Session
2. Intensive training post-spinal cord injury can stimulate repair in brain and spinal cord
3. Intensive care quality of sleep improved by new drug, reports study
4. Smoking Cessation Rates Double With Intensive Counseling and Free Nicotine Replacement Therapy, Studies of 20,000 Smokers Show
5. Browns Wives Host Special Day at MetroHealth Medical Center to Support the Neonatal Intensive Care Unit
6. Large intensive care study reveals vital recommendations for treatment of brain injury patients
7. Dangerous Condition Underscores Importance of Home Blood Pressure Monitoring
8. Cord Blood America Supports Trend From New York, California for States to Inform Parents of the Advantages of Umbilical Cord Blood Storage
9. Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells
10. Research shows a daily does of beetroot juice can beat high blood pressure
11. Hospital Patients Blood Clot Risk High
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... August 22, 2014 Top10BestSEOHosting.com has ... announces that iPage ( http://www.top10bestseohosting.com/go/iPage/ ) is one ... 2014. , The manager of Top10BestSEOHosting.com states, ... hosting supplier. Actually, these companies have outperformed their ... customer support. People can get the best web ...
(Date:8/21/2014)... Living in a quality residential community ... along with it. A quality Home Owners Association like ... are available. , Simpson Mill Plantation, ... Community Association Management, LLC made a recent investment in ... provide an additional amenity for their neighborhood. , Situated ...
(Date:8/21/2014)... coronary arteries of chronic kidney disease patients may be ... a new study in the Journal of the ... at the Johns Hopkins Bloomberg School of Public Health ... measures of subclinical atherosclerosis in predicting the risk of ... 50 percent of all patients with chronic kidney disease ...
(Date:8/21/2014)... 21, 2014 Improv performers from Fun ... with dementia at Silverado Turtle Creek memory care community ... of entertainers ranging from ages 10 to 16, delivers ... their 40-minute set. The troupe's philosophy is that improv ... allows them to touch audiences regardless of their circumstance ...
(Date:8/21/2014)... The City of Garden Grove is pleased ... for its inaugural “Re:Imagine Garden Grove – A Downtown ... 11 a.m. to 4 p.m., 2.85-miles of Garden Grove ... downtown will be filled with diverse music, dance, interactive ... (CARS), for all to enjoy. , The car-free route ...
Breaking Medicine News(10 mins):Health News:iPage Reviews Unveiled Online At Top10BestSEOHosting.com 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:Unicorn Clearance Improv Troupe Brings Laughter to Residents with Dementia at Silverado Memory Care 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 3Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 4
... ROCHESTER, Minn -- A new study led by Mayo Clinic ... a 41 percent reduction in colectomy after a year when ... October 2009 issue of Gastroenterology . Ulcerative colitis, ... the colon, is characterized by abdominal pain and diarrhea. Like ...
... Speaker Nancy Pelosi, Chairman John Dingell, and Congressman Martin ... conference this afternoon in the Capitol to discuss the benefits of ... reform legislation to senior citizens. Below are the Speaker,s ... Remarks: , "Good afternoon. Thank you all for being ...
... eleven public health and consumer advocacy organizations filed a ... court to reject a lawsuit by R.J. Reynolds, Lorillard ... provisions of the new federal law regulating tobacco products. ... industry,s challenge of a provision that requires FDA approval ...
... Time , With Rory Jaffe, MD, MBA ... J. Neuberger, Foley & Lardner LLP , MINNEAPOLIS, Sept. ... across the globe are grappling with possible wide-spread employee absenteeism ... the arrival of the H1N1 flu outbreak. To help organizations ...
... The Simmons firm, a leading national law firm in the ... second Miles for Meso 5K run/walk on Sunday, October 11, ... at www.milesformeso.org . , The Simmons ... 26 in Alton, Ill. Nearly 500 runners and walkers registered, ...
... Americans have cut back on medical care, survey finds , ... problems, 36 percent of Americans have cut back on doctor ... types of health visits they were reducing, 63 percent of ... percent said primary care physician visits and 52 percent said ...
Cached Medicine News:Health News:Ulcerative colitis treatment reduces need for surgery by almost half 2Health News:Pelosi: Health Reform Will Provide Seniors Better Benefits, Guaranteed Access to Doctors, Extended Stability for Medicare 2Health News:Pelosi: Health Reform Will Provide Seniors Better Benefits, Guaranteed Access to Doctors, Extended Stability for Medicare 3Health News:Eleven Health & Consumer Groups Urge Federal Court to Reject Tobacco Companies' Lawsuit Against FDA Tobacco Regulation Law 2Health News:Society of Corporate Compliance and Ethics to host What Compliance Professionals Need to Know about H1N1 Web Conference 2Health News:Society of Corporate Compliance and Ethics to host What Compliance Professionals Need to Know about H1N1 Web Conference 3Health News:Simmons Law Firm Presents Second 'Miles for Meso' Walk/Run Fundraiser for Mesothelioma Research 2Health News:Doctor Visits Are Getting Short Shrift in Tight Economy 2
(Date:8/21/2014)... Aug. 21, 2014 /PRNewswire-iReach/ -- ScriptPro has been ... under its Common Security Framework (CSF). According to ... Privacy Manager, "We appreciate this rigorous, top-to-bottom audit. ... that this certification signifies. Our business partners need ... THE CSF CERTIFICATION PROCESS: ScriptPro,s internal security processes ...
(Date:8/21/2014)... MELVILLE, N.Y. , Aug. 21, 2014  Henry Schein, ... of health care products and services to office-based dental, animal ... present at two investor conferences in September: , ... New York , NY at 12:50 p.m. ET ... Healthcare Conference in New York , NY at ...
(Date:8/21/2014)... -- The board of directors of VirtualScopics, Inc. (NASDAQ: ... imaging solutions, today announced that James Groff , ... Mr. Groff has held the role of acting chief ... January 2006 as an accounting manager and was promoted ... board of VirtualScopics asked Jim to assume the role ...
Breaking Medicine Technology:ScriptPro Achieves HITRUST Certification 2Henry Schein To Present At Two Investor Conferences In September 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 3VirtualScopics, Inc. Names James Groff Chief Financial Officer 4
... 25, 2011 /PRNewswire-Asia/ -- Simcere Pharmaceutical Group ("Simcere" or ... pharmaceutical company specializing in the development, manufacturing, and marketing ... announced that it has received the new drug approval ... Iremod. Iremod, which was independently developed by ...
... JUPITER, Fla., Aug. 25, 2011 BioRestorative Therapies, ... has entered into a Tangible Property License Agreement with ... enables BioRestorative Therapies to obtain adipose (fat) tissue that ... commercialize its ThermoStem Program , which is an ...
Cached Medicine Technology:Simcere's Iremod Receives SFDA New Drug Approval 2BioRestorative Therapies Signs License Agreement With University of Utah to Obtain Adipose (Fat) Tissue for its ThermoStem Program to Treat Obesity and Metabolic Disorders 2
... HandPort Systems non-adhesive sealing method ... Laparoscopic Surgrery (HALS) procedures, allowing ... and palpate throughout. Because HALS ... 6 cm, patients experience less ...
... offers a range of standard, enhanced ... delivers therapy to meet the needs ... in commercial and clinical effectiveness and ... the SleepStyle 200 series is the ...
The SleepStyle 600 series with ThermoSmart delivers humidification with anti-rainout benefits. ThermoSmart technology offers a heated breathing tube that allows the constant delivery of optimal level...
The S7 Elite is the premium device in ResMeds award-winning S7 series. All S7 devices include an option of integrated humidification....
Medicine Products: