Navigation Links
Intensive Rectal Cancer Treatment Shows Promise
Date:1/26/2010

Tumors were downstaged in most patients following chemo-surgery regimen, researchers say

TUESDAY, Jan. 26 (HealthDay News) -- An intensive treatment strategy shows promise against locally advanced rectal cancer.

The phase 2 study included 105 patients with poor-risk rectal cancer, meaning they have a high likelihood of disease recurrence and poor survival odds despite receiving standard chemotherapy and optimum surgery.

For this study, the patients underwent 12 weeks of chemotherapy treatment with capecitabine and oxaliplatin, followed by chemoradiotherapy with capecitabine and surgery, followed by another 12 weeks of capecitabine treatment.

After three years, 68 percent of the patients had no cancer progression, and the overall survival rate was 83 percent. After five years, the overall survival rate was 75 percent.

"Tumor downstaging was shown in most patients receiving neoadjuvant treatment with a low incidence of involved [circumferential resection margins (CRMs)] in the surgical specimens. Before treatment, 90 percent of eligible patients had tumors with CRMs at risk or involved," wrote David Cunningham, from the Royal Marsden Hospital in England, and colleagues.

"With no disease recurrences up to now in patients who achieved pathological complete response, this would be a valid endpoint to be used in future studies ... our efficacy and safety findings justify further evaluation of neoadjuvant chemotherapy," they concluded.

The study was published online Jan. 25 in The Lancet Oncology.

More information

The American Cancer Society has more about rectal cancer treatment.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Jan. 25, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Large intensive care study reveals vital recommendations for treatment of brain injury patients
2. Browns Wives Host Special Day at MetroHealth Medical Center to Support the Neonatal Intensive Care Unit
3. Smoking Cessation Rates Double With Intensive Counseling and Free Nicotine Replacement Therapy, Studies of 20,000 Smokers Show
4. Intensive care quality of sleep improved by new drug, reports study
5. Intensive training post-spinal cord injury can stimulate repair in brain and spinal cord
6. Susan G. Komen for the Cure Sharing Grassroots Advocacy Knowledge With International Representatives in Intensive Dallas Training Session
7. Intensive blood sugar treatment in trial of diabetes and cardiovascular disease changed
8. Construction Commencing at Gilbert Hospitals New Intensive Care Unit
9. Intensive care units prevention of pneumonia in critically-ill patients generally strong
10. Mayo Clinic Research Shows U.S. Intensive Care Units Prevention of Pneumonia in Critically-ill Patients Generally Strong; Identifies Area of Improvement
11. More intensive dialysis does not improve outcomes among patients with acute kidney injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... Boca Raton, FL (PRWEB) , ... January 21, 2017 , ... ... from Germany, announced it is bringing its product to the United States as part ... perfected over the last 25 years, Alcovit aims to reduce the productions of nasty ...
(Date:1/21/2017)... , ... January 21, 2017 , ... ... Alumni Relations, Dianne Travis-Teague, the electrifying line-up of events for its annual meeting ... family, friends, and community. “Coming Home 2017” will be held on Friday ...
(Date:1/21/2017)... ... 21, 2017 , ... The Nobel Biocare™ dental implant company ... for its creos™ line of bone regenerative products. Specifically, the Nobel ... utilizes creos™ allo.gain™ bone graft for a variety of bone reconstruction procedures. In ...
(Date:1/20/2017)... ... January 20, 2017 , ... Source Vitál Apothecary, a skin and body ... oils, announced the company had a successful visit to the 2017 ECRM Diet, Vitamin ... companies that work in the nutritional, sports and health industries a chance to meet ...
(Date:1/20/2017)... ... January 20, 2017 , ... ATP Science, an Australian-based ... recently attended the January ECRM Trade Show in Hilton Head, SC, benefiting from ... large range of supplements that keep the body functioning at its peak performance ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Incretin Mimetics/GLP-1 Agonists, SNDRIs, Lipase Inhibitors, Serotonin Receptor Agonists, Sympathomimetic-GABA ... drugs market is expected to grow at a CAGR of ... of 38.7% in the second half of the forecast period. The ... 2016 to 2027. The market is estimated at $1,058 million in ... ...
(Date:1/19/2017)... James Gilbart , ... 2016;12(Suppl 2):3-8; http://www.touchoncology.com/articles/optimising-clinical-outcomes-gastrointestinal-cancers-through-inhibiting-angiogenesis-and ... ... recently in a supplement to European Oncology & ... article by James Gilbart and ...
(Date:1/19/2017)... PALO ALTO, Calif. , Jan. 19, 2017 /PRNewswire/ ... scientific research, is excited to announce that the ... Project: Cancer Biology  (RP:CB) have been published in ... science, this project represents the first practical evaluation ... that result in reproducible studies. Unlike other assessments ...
Breaking Medicine Technology: