Navigation Links
Intensive Rectal Cancer Treatment Shows Promise
Date:1/26/2010

Tumors were downstaged in most patients following chemo-surgery regimen, researchers say

TUESDAY, Jan. 26 (HealthDay News) -- An intensive treatment strategy shows promise against locally advanced rectal cancer.

The phase 2 study included 105 patients with poor-risk rectal cancer, meaning they have a high likelihood of disease recurrence and poor survival odds despite receiving standard chemotherapy and optimum surgery.

For this study, the patients underwent 12 weeks of chemotherapy treatment with capecitabine and oxaliplatin, followed by chemoradiotherapy with capecitabine and surgery, followed by another 12 weeks of capecitabine treatment.

After three years, 68 percent of the patients had no cancer progression, and the overall survival rate was 83 percent. After five years, the overall survival rate was 75 percent.

"Tumor downstaging was shown in most patients receiving neoadjuvant treatment with a low incidence of involved [circumferential resection margins (CRMs)] in the surgical specimens. Before treatment, 90 percent of eligible patients had tumors with CRMs at risk or involved," wrote David Cunningham, from the Royal Marsden Hospital in England, and colleagues.

"With no disease recurrences up to now in patients who achieved pathological complete response, this would be a valid endpoint to be used in future studies ... our efficacy and safety findings justify further evaluation of neoadjuvant chemotherapy," they concluded.

The study was published online Jan. 25 in The Lancet Oncology.

More information

The American Cancer Society has more about rectal cancer treatment.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Jan. 25, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Large intensive care study reveals vital recommendations for treatment of brain injury patients
2. Browns Wives Host Special Day at MetroHealth Medical Center to Support the Neonatal Intensive Care Unit
3. Smoking Cessation Rates Double With Intensive Counseling and Free Nicotine Replacement Therapy, Studies of 20,000 Smokers Show
4. Intensive care quality of sleep improved by new drug, reports study
5. Intensive training post-spinal cord injury can stimulate repair in brain and spinal cord
6. Susan G. Komen for the Cure Sharing Grassroots Advocacy Knowledge With International Representatives in Intensive Dallas Training Session
7. Intensive blood sugar treatment in trial of diabetes and cardiovascular disease changed
8. Construction Commencing at Gilbert Hospitals New Intensive Care Unit
9. Intensive care units prevention of pneumonia in critically-ill patients generally strong
10. Mayo Clinic Research Shows U.S. Intensive Care Units Prevention of Pneumonia in Critically-ill Patients Generally Strong; Identifies Area of Improvement
11. More intensive dialysis does not improve outcomes among patients with acute kidney injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... Intermedix ... of Emergency Medicine , an emergency medicine professional association, to support the organization's ... , The American Academy of Emergency Medicine, or AAEM, seeks to empower emergency ...
(Date:2/10/2016)... , ... February 10, 2016 , ... Emergency rooms provide ... to find. Unfortunately, this can leave patients with dental emergencies at risk of losing ... now offering emergency dental care. , Common dental emergencies include:, ...
(Date:2/10/2016)... ... February 10, 2016 , ... Dr. Jessica Barron, of ... is now accepting new dental patients and families in the North Metro Denver area. ... services from cleanings to cosmetic dentistry, and all in the most relaxing environment. , ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... organization, welcomes S.S. Nesbitt as the latest addition to its growing list of ... other locations throughout the Southeast, from Orlando to Huntsville and in between. , ...
(Date:2/10/2016)... ... , ... Armune BioScience signed a definitive agreement with ARCpoint ... across the country. Launched in April of 2015, Apifiny is the only cancer specific, ... order volume exceeded 3,000 tests in 2015. Primary care physicians and urologists have utilized ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... LONDON , February 10, 2016 A new report ... 2021 - states that the Alzheimer,s disease market will more than double ... 2021, at a Compound Annual Growth Rate (CAGR) of 11%. ... Italy , Spain , the UK, and ... prevalence during the forecast period. --> Canada , ...
(Date:2/10/2016)... SAN DIEGO , Feb. 10, 2016 ... viral gene therapy manufacturing, and Renova™ Therapeutics, a biopharmaceutical ... and other chronic diseases, have entered into a Manufacturing ... produce cGMP-grade RT-100 (Ad5.hAC6) Drug Product for use in ... --> This relationship will leverage Lonza,s ...
(Date:2/10/2016)... , Feb. 10, 2016 Immune Pharmaceuticals Inc. ... announced today that it has filed a patent application ... other cancers. --> --> ... by administration of Ceplene (histamine dihydrochloride) in combination with ... of predicting the efficacy of Ceplene and IL-2 therapy ...
Breaking Medicine Technology: