Navigation Links
Intensive Insulin Therapy Won't Boost Septic Shock Survival
Date:1/26/2010

Outcome similar to conventional insulin treatment, study shows

TUESDAY, Jan. 26 (HealthDay News) -- Among adult septic shock patients, intensive insulin therapy to lower high blood glucose levels caused by corticosteroid therapy doesn't reduce the risk of death, a new study has found.

The death rate for septic shock -- a major complication of bacterial infections -- is 60 percent within a short period, according to background information in the study. Corticosteroids are used to treat septic shock but their use is associated with elevated blood glucose levels (hyperglycemia).

In the new study, published in the Jan. 27 issue of the Journal of the American Medical Association, researchers in France examined whether intensive insulin therapy would improve outcomes among adult septic shock patients treated with hydrocortisone.

The study included 509 patients randomly selected to one of four groups: continuous intravenous infusion with hydrocortisone alone; continuous intravenous infusion with hydrocortisone plus another corticosteroid called fludrocortisone; conventional insulin therapy with hydrocortisone alone; or conventional insulin therapy with intravenous hydrocortisone plus fludrocortisone. Hydrocortisone was administered every six hours, and fludrocortisone was administered once daily for one week.

Overall, 117 of the 255 patients (45.9 percent) treated with intensive insulin therapy died, along with 109 of 254 (42.9 percent) of patients who received conventional insulin therapy. There were no major differences between the two groups in any of the secondary outcome measures, such as days spent in the intensive care unit or length of hospital stay.

The researchers also found that patients in the intensive insulin therapy group had significantly more episodes of hypoglycemia (low blood sugar) than those in the conventional insulin therapy group.

The use of a second corticosteroid offered no benefit. The death rate for patients who received fludrocortisone was 42.9 percent, compared with 45.8 percent for those in the conventional insulin therapy group.

"The current study showed no evidence to support a strategy of intensive insulin therapy aimed at maintaining blood glucose levels in the range of 80 to 110 milligrams per deciliter for treating septic shock with corticosteroids," the researchers wrote. "The current data do not support the routine use of oral fludrocortisone in addition to hydrocortisone when physicians decide to introduce corticosteroids in the management of a patient with septic shock."

More information

The U.S. National Institute of General Medical Sciences has more about sepsis.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, Jan. 26, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Intensive Rectal Cancer Treatment Shows Promise
2. The Breema Center Announces Its Winter Intensive
3. Intensive Dialysis Doesnt Save Lives of the Sickest
4. Intensive care units poorly equipped to care for the dying
5. University Medical Center Mainz Completes Installation of Masimo Noninvasive and Continuous Hemoglobin Throughout Their Operating Rooms, Intensive Care Units and Emergency Department
6. Integrated Medical Systems Receives CE Mark for Worlds First Suitcase Intensive Care Unit
7. The Breema Center Presents Its Fall Week-Long Intensive on Giving and Receiving Breema Bodywork
8. Integrated Medical Systems Receives $1.1 Million From the U.S. Department of Defense for Critical Enhancements of the Worlds First Suitcase Intensive Care Unit
9. Integrated Medical Systems Receives $3.25 Million from the U.S. Army for Worlds First Suitcase Intensive Care Unit
10. Integrated Medical Systems Ships Worlds First Suitcase Intensive Care Unit to U.S. Army
11. Innovator's Studio offers Social Media Strategy Intensive Sept 16-17, 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... Fla. (PRWEB) , ... October 12, 2017 , ... IsoComforter, ... therapy products, announced today the introduction of an innovative new design of the shoulder ... pad so you get maximum comfort while controlling your pain while using cold therapy. ...
(Date:10/12/2017)... Rockville, Maryland (PRWEB) , ... October 12, 2017 ... ... a magnetic drug delivery system that we intend to develop to enable prevention ... regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
(Date:10/12/2017)... ... ... Health Literacy Innovations (HLI), creator of the Health Literacy ... Patient Education Network (CPEN), an independent professional organization that shares best practices in ... , As CPEN’s strategic partner, HLI will help support CPEN members by sharing ...
(Date:10/12/2017)... Washington, D.C. (PRWEB) , ... October 12, 2017 ... ... Company, Cal Dining at the University of California Berkeley, and other leading institutions ... leverages the buying power of institutions to change the way animals are raised ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... HORSHAM, Pa. , Sept. 22, 2017 ... received a complete response letter from the U.S. Food ... (BLA) seeking approval of sirukumab for the treatment of ... response letter indicates additional clinical data are needed to ... of moderately to severely active RA. ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017   ... for global supply chains, has published the first annual edition of its ... of more than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings ... 2016. ... CSR Risk & Performance Index ...
Breaking Medicine Technology: