Navigation Links
Intellectual disability is frequently caused by non-hereditary genetic problems
Date:4/18/2011

This release is available in French.

Mutations in a group of genes associated with brain activity frequently cause intellectual disability, according to a study led by scientists affiliated with the University of Montreal and the research centre at the Centre hospitalier universitaire Sainte-Justine. Intellectual disability is a severe handicap that affects between one and two percent of children worldwide. It can often be attributed to genetic causes, but the specific genes involved were mostly unknown. "The group of genes we identified all play important roles in nerve synapses, the structures that allow brain cells to rapidly transfer information," explained senior author Dr. Jacques Michaud. "These findings indicate that, in this case, intellectual disability occurs because there is a disruption in nerve cell communication."

Some intellectual disabilities are associated with physical abnormalities that indicate major genetic abnormalities. However, in other cases disabilities are not associated with obvious physical traits "We targeted non-syndromic patients," Michaud said. Together with his colleagues from the Synapse to Disease Project, Michaud analyzed DNA from the patients to identify mutations that were not inherited but were in fact newly formed. These are called de novo mutations. They studied 197 synaptic genes and identified de novo mutations in 10 of the 95 patients. Further studies indicated that all of these mutations affect nerve cell communication, which lead the team to conclude that at least two-thirds of the mutations are the definitive cause of the disorder.

"This finding aligns with our previous work that shows that de novo mutations play important roles in disorders such as autism and schizophrenia," said co-author Guy Rouleau. "Our study indicates that a large fraction of cases with intellectual disability have a g
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-566-3813
University of Montreal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Research Demonstrates Gains in Emergent Reading Skills for Adolescents with Autism and Intellectual Disabilities
2. Alzheimers Foundation of America Applauds Social Security for Speeding Disability Benefits for Early-Onset Alzheimers Disease
3. The American Association on Health and Disability (AAHD) and the Susan G. Komen for the Cure Partner to Increase Accessibility for Women with Disabilities at Mammogram Facilities in the DC Metro Area
4. Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction
5. Pioneering treatment reduces disability in premature babies with serious brain hemorrhage
6. Regenstrief Institute to help improve disability determination through health information technology
7. Sokolove Law Helps Thousands of Consumers Fight Unfair Disability Insurance Denial
8. Black men with chronic pain at higher risk for depression, disability
9. New Disability Benefits Could Soon Be Available to Vietnam Vets
10. Allsup Outlines Quick-Processing Methods for Social Security Disability Claims
11. Getting Help with Initial Social Security Disability Application Can Speed Access to Benefits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... The University of Scranton has launched ... to answer the growing demand for professionals trained ... wellness profile for better individual, real-world care. , ... implementation of health services and systems. This is ... operations in the healthcare sector,” says Margarete Zalon, ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 On ... the grand opening of its Center for Graduate ... Hollywood Presbyterian Hospital. The campus recently completed a ... the only thing that has administrators and students ... expanded from the Master of Science in Nursing, ...
(Date:4/21/2015)... Springs, FL (PRWEB) April 21, 2015 ... these are a few of the Earth Day topics ... As state and national leaders debate the affect of ... offers a variety of subject matter touching on the ... The compelling segments will delve into sustainable lifestyles, clean ...
(Date:4/21/2015)... This program provides physical therapists, ... occupational therapist assistants, teachers, and other school based ... children across the autism spectrum succeed in the ... Inc. , Used throughout the United ... yoga curriculum addresses learning and behavior issues across ...
(Date:4/20/2015)... Falls Church, VA (PRWEB) April 21, 2015 ... How Sponsors and CMOs Speed Production and Improve Compliance ... – 3:00 p.m. EDT, http://www.fdanews.com/qualitybydesign , The ... that are forcing them to do more with less. ... forcing sponsors and CMOs to finds ways to speed ...
Breaking Medicine News(10 mins):Health News:The University of Scranton Launches Online MS in Health Informatics 2Health News:The University of Scranton Launches Online MS in Health Informatics 3Health News:West Coast University Opens a Center for Graduate Studies 2Health News:West Coast University Opens a Center for Graduate Studies 3Health News:USM Studios’ Programming Focuses on the Environment 2Health News:ABC News Interviews Anne Buckley-Reen, Education Resources Inc. Faculty Member, on Yoga Therapy in the Classroom 2Health News:FDAnews Announces — Using Quality by Design to Improve Manufacturing: How Sponsors and CMOs Speed Production and Improve Compliance Webinar, May 7, 2015 2Health News:FDAnews Announces — Using Quality by Design to Improve Manufacturing: How Sponsors and CMOs Speed Production and Improve Compliance Webinar, May 7, 2015 3
... RBC Life Sciences (OTC Bulletin Board: RBCL) announced ... Price, to CEO effective January 1, 2009. Company founder, ... chairman of the board of directors.The promotion comes at ... of proprietary nutritional supplements, wound care and pain management ...
... Dental Network of America (DNoA) and Philips Consumer ... America Corporation (Philips), just signed an agreement, effective ... "DNoA Preferred Network" dentists in Illinois, Oklahoma and ... Sonicare(TM) product line."Partnering with Philips on offering the ...
... January 30th noon to 5PM in our new Hyundai Dealer showroom at 271 ... the first 50 to donate blood. , ... Wilmington, MA (PRWEB) January 5, 2009 -- Bill Dube ... blood as the recent ice & snow storms that hit New England have canceled ...
... China, Jan. 5 /PRNewswire-Asia-FirstCall/ -- China Nepstar Chain,Drugstore ... "the Company"), the largest retail,drugstore chain in China ... announced that its Board of Directors and the ... termination of a voting rights agreement which,assigned 30% ...
... foods consumed during pregnancy might protect against asthma and ... apple a day while you,re pregnant may indeed keep ... your unborn child. , Recent research suggests ... have lower rates of asthma. , And, mothers who ...
... Today,s fast-paced,demanding culture often makes it challenging to ... health. Karate, which is most commonly,recognized as a means ... to help anyone achieve a fit body; relieve stress; ... her leadership skills. , Karate ...
Cached Medicine News:Health News:RBC Life Sciences Promotes Industry Veteran John W. Price to CEO; Company Founder, Clinton Howard, Will Remain Chairman of the Board 2Health News:RBC Life Sciences Promotes Industry Veteran John W. Price to CEO; Company Founder, Clinton Howard, Will Remain Chairman of the Board 3Health News:Dental Network of America and Philips Sign Agreement to Offer Sonicare Products to Dental Providers 2Health News:Boston Hyundai Dealer Teams up With the Red Cross to Save Lives 2Health News:China Nepstar Chain Drugstore Terminates Voting Rights Agreement for Yunnan Subsidiary 2Health News:China Nepstar Chain Drugstore Terminates Voting Rights Agreement for Yunnan Subsidiary 3Health News:China Nepstar Chain Drugstore Terminates Voting Rights Agreement for Yunnan Subsidiary 4Health News:Prenatal Nutrition, Postnatal Allergy Protection 2Health News:Prenatal Nutrition, Postnatal Allergy Protection 3Health News:Karate For Your Body Announces Release of Volume One in Martial Arts DVD Training Series, 'Focusing On Fundamentals' 2
(Date:4/20/2015)... -- Ameritox,s Ingenuity Health, a leading provider of monitoring solutions ... the National Council of Behavioral Health annual conference in ... 25 percent of the samples collected from patients with ... antipsychotic medication. ... Medication nonadherence can ...
(Date:4/20/2015)... 2015 International Isotopes Inc. (OTCQB: INIS, ... with the following update on its business segments. ... Historically, INIS has produced and sold high-activity ... of sealed sources for medical and industrial applications.  ... security examination, and radiography.  Due to technical issues ...
(Date:4/20/2015)... NEW YORK , April 20, 2015 /PRNewswire/ ... insulin pump market will continue to be robust; ... increasing incidence of diabetes, expanding global markets, new ... growth, there are relatively steady market inhibitors, such ... and an increasing competitive environment. The healthcare market ...
Breaking Medicine Technology:Ingenuity Health Research Flags Potentially High Rate of Medication Nonadherence Among Those with Serious Mental Illness 2Ingenuity Health Research Flags Potentially High Rate of Medication Nonadherence Among Those with Serious Mental Illness 3International Isotopes Inc. Provides Shareholders With An Update On New Opportunities And Positive Developments Within Its Existing Business Segments 2International Isotopes Inc. Provides Shareholders With An Update On New Opportunities And Positive Developments Within Its Existing Business Segments 3International Isotopes Inc. Provides Shareholders With An Update On New Opportunities And Positive Developments Within Its Existing Business Segments 4International Isotopes Inc. Provides Shareholders With An Update On New Opportunities And Positive Developments Within Its Existing Business Segments 5Kalorama: Insulin Pump Market Growing Robustly 2Kalorama: Insulin Pump Market Growing Robustly 3
... HASCO Medical, Inc. (OTC Bulletin Board: HASC ... serves patients in Alabama, Florida, and Mississippi, today announced ... additional 8,000+ products available for immediate delivery. ... and affordable for patients throughout the United States to ...
... 25, 2011 Elekta,s MOSAIQ®* oncology electronic ... certification. Complete EMR certification officially validates the Elekta ... demonstrate Stage 1 meaningful use under the HITECH ... the Drummond Group,s Electronic Health Records Office of ...
Cached Medicine Technology:HASCO Medical Expands Online Offering 2Elekta's Oncology-Specific MOSAIQ Receives Complete ONC-ATCB EMR Certification 2Elekta's Oncology-Specific MOSAIQ Receives Complete ONC-ATCB EMR Certification 3
... The Bledsoe Wee Walker Pediatric ... low profile pediatric boot that ... unsurpassed support. Only two sizes ... cost. These sizes will fit ...
... is a shorter and lighter version ... second degree ankle sprains, toe and ... Bledsoe EZ Set Mid-Calf Boot is ... 20 degrees of dorsi-flexion to 40 ...
... Diabetic Boot features a fully enclosed thick, ... unique auto-molding innersole which embeds into a ... aluminum shelled walking boot. This unique Automold™ ... distribute body weight across the entire bottom ...
... Bird and Cronin, ... manufacturer of Patient Footwear, ... Patient Care Products. Our ... highest quality and available ...
Medicine Products: