Navigation Links
Intellectual disability is frequently caused by non-hereditary genetic problems
Date:4/18/2011

This release is available in French.

Mutations in a group of genes associated with brain activity frequently cause intellectual disability, according to a study led by scientists affiliated with the University of Montreal and the research centre at the Centre hospitalier universitaire Sainte-Justine. Intellectual disability is a severe handicap that affects between one and two percent of children worldwide. It can often be attributed to genetic causes, but the specific genes involved were mostly unknown. "The group of genes we identified all play important roles in nerve synapses, the structures that allow brain cells to rapidly transfer information," explained senior author Dr. Jacques Michaud. "These findings indicate that, in this case, intellectual disability occurs because there is a disruption in nerve cell communication."

Some intellectual disabilities are associated with physical abnormalities that indicate major genetic abnormalities. However, in other cases disabilities are not associated with obvious physical traits "We targeted non-syndromic patients," Michaud said. Together with his colleagues from the Synapse to Disease Project, Michaud analyzed DNA from the patients to identify mutations that were not inherited but were in fact newly formed. These are called de novo mutations. They studied 197 synaptic genes and identified de novo mutations in 10 of the 95 patients. Further studies indicated that all of these mutations affect nerve cell communication, which lead the team to conclude that at least two-thirds of the mutations are the definitive cause of the disorder.

"This finding aligns with our previous work that shows that de novo mutations play important roles in disorders such as autism and schizophrenia," said co-author Guy Rouleau. "Our study indicates that a large fraction of cases with intellectual disability have a g
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-566-3813
University of Montreal
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. New Research Demonstrates Gains in Emergent Reading Skills for Adolescents with Autism and Intellectual Disabilities
2. Alzheimers Foundation of America Applauds Social Security for Speeding Disability Benefits for Early-Onset Alzheimers Disease
3. The American Association on Health and Disability (AAHD) and the Susan G. Komen for the Cure Partner to Increase Accessibility for Women with Disabilities at Mammogram Facilities in the DC Metro Area
4. Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction
5. Pioneering treatment reduces disability in premature babies with serious brain hemorrhage
6. Regenstrief Institute to help improve disability determination through health information technology
7. Sokolove Law Helps Thousands of Consumers Fight Unfair Disability Insurance Denial
8. Black men with chronic pain at higher risk for depression, disability
9. New Disability Benefits Could Soon Be Available to Vietnam Vets
10. Allsup Outlines Quick-Processing Methods for Social Security Disability Claims
11. Getting Help with Initial Social Security Disability Application Can Speed Access to Benefits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... TUESDAY, May 21 (HealthDay News) -- The risk of ... when parents sleep with their infant, a new study ... risk for SIDS even if parents do not drink, ... of SIDS, which is a major cause of infant ... did not sleep with their babies. In the ...
(Date:5/21/2013)... Brussels proposes to include on tobacco packages in order ... on smokers because they only find some of them ... improve the efficacy of its anti-smoking campaigns, it should ... stronger emotional impact., These are some of the conclusions ... and Psychological Treatment at the University of Granada by ...
(Date:5/21/2013)... have long been known for their health benefits, ... therapies like anti-cancer drugs are delivered to specific ... uncovered how to create nanoparticles using natural lipids ... use them as drug delivery vehicles. UofL scientists ... their team today (May 21, 2013), published their ...
(Date:5/21/2013)... Tulsa, OK (PRWEB) May 21, 2013 Representatives ... has been such a success that the company has achieved ... re-launch plan from day one was to move Hammerhead Bicycles ... Company Spokesman and President Scott Robertson. , Robertson explained that ... and continue to exclusively focus on all things 29er ...
(Date:5/21/2013)... 2013 TheBeautyPlace.com helps brides to breathe ... a Big Day Kit including all the essentials a ... shine on their Wedding Day. , TheBeautyPlace.com features Wedding ... on their Wedding Day. Flowers blooming and warmer weather ... wedding season. From Memorial Day to October, brides to ...
Breaking Medicine News(10 mins):Health News:Bed-Sharing Raises SIDS Risk Fivefold, Study Finds 2Health News:Warning images for cigarette packs proposed by Europe do not make enough emotional impact 2Health News:UofL scientists uncover how grapefruits provide a secret weapon in medical drug delivery 2Health News:Hammerhead Bicycles Now a Standalone Brand 2Health News:TheBeautyPlace.com Previews their Emergency Big Day Kit to Get Brides Ready For this Upcoming Wedding Season 2Health News:TheBeautyPlace.com Previews their Emergency Big Day Kit to Get Brides Ready For this Upcoming Wedding Season 3
... is pondering, , TUESDAY, July 28 (HealthDay News) -- A ... raise the age at which American women should start Pap ... age at which a woman should first have a Pap ... States, however, women are told to get regular Pap smears ...
... , LAS VEGAS, July 28 American Pacific ... will release its Fiscal 2009 third quarter financial results on Tuesday, August 4, ... to participate in a teleconference to review the financial results and outlook of ... August 4, 2009 at 1:30 p.m. PDT. To access the call please dial ...
... , , DENVER, ... around the world were honored for research projects that improved ... projects were funded through Morris Animal Foundation,s (MAF) Veterinary Student ... annual meeting in June. Members of MAF,s esteemed scientific advisory ...
... , , , ... company that is expected to become public following the planned spinoff of ... 10 registration statement for the spinoff has been declared effective by the ... The effectiveness of the Form 10 was one of the few ...
... , , DETROIT, July 28 ... net sales of $48.1 million in the first quarter of Fiscal ... corresponding period of Fiscal 2009. The reduction in sales was primarily ... period, as compared to the corresponding period of Fiscal 2009. Sales ...
... , , CUPERTINO, Calif., July 28 ... Matthew Hogan, Chief Financial Officer, will be presenting at the BMO ... 5 at 4:00 pm Eastern Time. The conference is being ... A webcast of the presentation will be accessible at: ...
Cached Medicine News:Health News:Teens May Not Benefit from Pap Tests 2Health News:Teens May Not Benefit from Pap Tests 3Health News:American Pacific to Release Financial Results and Hold Fiscal 2009 Third Quarter Investor Teleconference 2Health News:Eleven Veterinary Students Win Top Awards at Morris Animal Foundation's Annual Research Competition 2Health News:Eleven Veterinary Students Win Top Awards at Morris Animal Foundation's Annual Research Competition 3Health News:Eleven Veterinary Students Win Top Awards at Morris Animal Foundation's Annual Research Competition 4Health News:CareFusion Form 10 Registration Statement Declared Effective 2Health News:CareFusion Form 10 Registration Statement Declared Effective 3Health News:CareFusion Form 10 Registration Statement Declared Effective 4Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 2Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 3Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 4Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 5Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 6Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 7Health News:DURECT to Present at the BMO Capital Markets Healthcare Conference 2
(Date:5/21/2013)... Abaxis, Inc. (NasdaqGS: ABAX), a medical products ... Martin Mulroy , chief commercial officer ... Veterinary Conference on Wednesday, May 29, 2013 at 11:30 ... Parker Meridien Hotel in New York City ... develops, manufactures, markets and sells portable blood analysis systems ...
(Date:5/21/2013)... , May 21, 2013 Ceregene, Inc. ... analysis of its double-blind, randomized, controlled Phase 2b ... gene therapy product designed to deliver the neurotrophic ... identified a more robust response to CERE-120 in ... treatment relative to those diagnosed 10 years or ...
(Date:5/21/2013)... 2013   RxAlly , a first-of-its-kind alliance ... the publication of a white paper entitled Personalized ... The white paper highlights an unprecedented solution for ... engagement to avert strains on the health care ... a range of individually-tailored, pharmacist-provided clinical and consultative ...
Breaking Medicine Technology:Abaxis, Inc. to Present at the Stifel Annual Dental & Veterinary Conference 2Ceregene Reports Additional Efficacy Data From Parkinson's Disease Phase 2b Study 2Ceregene Reports Additional Efficacy Data From Parkinson's Disease Phase 2b Study 3Ceregene Reports Additional Efficacy Data From Parkinson's Disease Phase 2b Study 4Ceregene Reports Additional Efficacy Data From Parkinson's Disease Phase 2b Study 5RxAlly Releases White Paper on Necessity of Personalized Pharmacist Care 2RxAlly Releases White Paper on Necessity of Personalized Pharmacist Care 3
... one of New Zealand,s leading hospitals have delivered more ... in the first month of its implementation. The TrueBeam ... ) adds to Wellington Hospital,s radiotherapy capabilities and enables ... first patient in the country – and the southern ...
Belgium, United Kingdom, Austria and The Netherlands. The DORC companies employ about 300 people. Visit our website : http://www.dorc.nl  ...
Cached Medicine Technology:Wellington Hospital, New Zealand Becomes First in Southern Hemisphere to Offer Patients Fast and Precise TrueBeam Treatments 2Wellington Hospital, New Zealand Becomes First in Southern Hemisphere to Offer Patients Fast and Precise TrueBeam Treatments 3
Size: Medium. 22.50 mm by 24.00 mm. Clear lucite. Supplied sterile....
... 6.4 x 80 mm. Storz offers ... designed by Harvey A. Lincoff, M.D. ... cell sponge which is non-toxic and ... edges to minimize scleral intrusion. These ...
... x 80 mm. Storz offers the ... by Harvey A. Lincoff, M.D. The ... which is non-toxic and non-antigenic. Implants ... minimize scleral intrusion. These implants are ...
... Size: 5.0 x 2.5 x 80 mm. Half ... by Harvey A. Lincoff, M.D. has been modified ... design. The material is a closed cell sponge ... with rounded edges to minimize scleral intrusion. These ...
Medicine Products: