Navigation Links
Integrating genetic information with breast cancer risk factors may help refine prognosis
Date:4/1/2008

plied to further characterize clinically relevant heterogeneity (diversity) in early stage breast cancer.

The researchers found that integrating gene expression signatures into clinical risk stratification could refine prognosis for patients in three risk subgroups (low, intermediate, and high) and help predict relapse-free survival and response to chemotherapy.

Pending future prospective clinical validation, these results provide preliminary evidence that the profusion of gene expression signatures in defining breast cancer, if used appropriately, represent less of a paradox and should be viewed as an important complementary approach to current clinicopathological risk stratification systems. Furthermore, knowledge of increased likelihood of sensitivity to specific chemotherapeutic agents from a repertoire of drugs that are commonly used to treat breast cancer is something that could be more immediately used in current clinical practice, once issues regarding cost and accessibility are addressed, in instances wherein multiple chemotherapeutics or chemotherapeutic combinations are Food and Drug Administration approved, as in early stage breast cancer, and are considered the standard of care, the authors conclude.

(JAMA. 2008;299[13]:1574-1587. Available pre-embargo to the media at www.jamamedia.org)

Editors Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


Editorial: Use of Gene Signatures to Improve Risk Estimation in Cancer

In an accompanying editorial, Chiang-Ching Huang, Ph.D., and Markus Bredel, M.D., Ph.D., of the Feinberg School of Medicine, Northwestern University, Chicago, write that these findings are promising.

In essence, the study by Acharya et al demonstrates the potential value of using microarray-based gene si
'/>"/>

Contact: Lauren Shaftel
919-684-4148
JAMA and Archives Journals
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Integrating Quality into Business Systems for High Performance, Complimentary Excerpt Available from Best Practices, LLC
2. Integrating Quality into Business Systems for High Performance, Complimentary Excerpt Available from Best Practices, LLC
3. PARADE Magazine Features Smart Genetics and Alzheimers Mirror
4. Interleukin Genetics Reports Fourth Quarter and Year End 2007 Financial Results
5. Schizophrenia Tied to Multiple Genetic Errors
6. Genetic test improves artificial fertilization
7. Large multicenter study suggests new genetic markers for Crohns disease
8. MRI: A window to genetic properties of brain tumors
9. Genetic Engineering & Biotechnology News reports on clinical trials in developing countries
10. Genetic Medicine Making Inroads Against Disease
11. Family communication impacts attitude about genetic counseling/testing for breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Heritage Woods of McLeansboro, a Gardant ... Week Celebration on April 20 with a day full ... body and soul. , The community, which is located ... adults of all incomes, including those on Medicaid, who ... Living Week is observed every April and highlights the ...
(Date:4/17/2015)... Oklahoma (PRWEB) April 17, 2015 Alcohol ... Drug Dependence (NCADD) notes that drinking and driving has ... At the same time, the link between alcohol ... as domestic abuse and violence and sexual assault, and ... According to the NCADD, 5.3 million adults in America ...
(Date:4/17/2015)... Consumers who prefer to have a standard ... use the Insurance Pros USA website for web research. ... are featured by leading companies quoting plans at ... are mixed between three of the most popular coverage ... now term, universal and whole policies that are quoted ...
(Date:4/17/2015)... Most dental patients are not aware that ... overseas by foreign dental laboratories, according to the U.S. ... more than 40 states by their respective state boards ... Laboratories has created the “What’s In Your ... the consequences that could be associated with using poorly-made ...
(Date:4/17/2015)... The American College of Traditional Chinese Medicine (ACTCM) is ... April 29. The event will be held from 11 a.m. to ... St. in San Francisco, CA. , The agenda for the day ... DeHaro campus (room F), 11:10 a.m. – Introduction and welcome ... lunch with current students, faculty and staff, 1 p.m. – Observe ...
Breaking Medicine News(10 mins):Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 3Health News:General Life Insurance Policy Rates Added to Quotation System at Insurance Website Online 2Health News:National Association Urges Transparency in Dental Industry 2Health News:American College of Traditional Chinese Medicine Hosts Open House 2
... ... ... -- CMS Watch announced today that it has changed its name to The Real ... , , ,“The new name better reflects what we,ve been doing for nearly a decade: ...
... , ... ... ... ...
... , ... ... ... ...
... of certain proteins in premalignant oral lesions may ... researchers said. SIBLINGs, or Small Integrin-Binding Ligand ... that help mineralize bone but can also spread ... breast, lung, colon and prostate. "Several years ...
... 10-15 years. After this time, the operation has to be ... as, in general, it is elderly people that use the ... Donostia-San Sebastin, has just published her PhD, a thesis which ... According to Ms Garmendia, using a ceramic material called zirconia ...
... ... presented at WebInno25 , ... New York, NY (PRWEB) February 23, 2010 -- Vizibility Inc. ( www.vizibility.com ... branding service for career professionals at Web Innovators Group (aka WebInno) in Boston. Hosted ...
Cached Medicine News:Health News:CMS Watch Changes Name to The Real Story Group 2Health News:CMS Watch Changes Name to The Real Story Group 3Health News:Diabetics Twice as Likely to Have Hearing Loss; Florida HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 2Health News:Diabetics Twice as Likely to Have Hearing Loss; Florida HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 3Health News:Diabetics Twice as Likely to Have Hearing Loss; Florida HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 4Health News:Diabetics Twice as Likely to Have Hearing Loss; Florida HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 5Health News:Diabetics Twice as Likely to Have Hearing Loss; Florida HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 6Health News:Global Hospitals and Healthcare Suppliers Focus on Cutting Costs and Improving Quality at 2010 GHX Supply Chain Summit 2Health News:Global Hospitals and Healthcare Suppliers Focus on Cutting Costs and Improving Quality at 2010 GHX Supply Chain Summit 3Health News:Global Hospitals and Healthcare Suppliers Focus on Cutting Costs and Improving Quality at 2010 GHX Supply Chain Summit 4Health News:Global Hospitals and Healthcare Suppliers Focus on Cutting Costs and Improving Quality at 2010 GHX Supply Chain Summit 5Health News:SIBLING proteins may predict oral cancer 2Health News:Material tested that could guarantee body protheses for more than 150 years 2Health News:Vizibility A Side Dish At Web Innovators Group Event 2Health News:Vizibility A Side Dish At Web Innovators Group Event 3
(Date:4/17/2015)... RALEIGH, N.C. , April 17, 2015 /PRNewswire/ ... of the Integrated Embolic Protection™ filter platform for ... completion of a $5.6 million Series B financing ... stage venture firm with a focus on medical ... medicine. The round also included Mountain Group Partners, ...
(Date:4/17/2015)... 17, 2015 LifeScienceIndustryResearch.com announces ... Report on Global and China Lysine Industry to ... professional and the deep research report in this ... basic information including definition, classification specifications, application, industry ... Europe , Japan ...
(Date:4/17/2015)... , April 17, 2015 CVS Health ... conference call on Friday, May 1, 2015, at 8:30 ... first quarter financial results. An audio webcast ... the Investor Relations portion of the CVS Health website ... http://investors.cvshealth.com . This webcast will be archived and ...
Breaking Medicine Technology:Contego Medical Closes $5.6 Million in Series B Funding 2Contego Medical Closes $5.6 Million in Series B Funding 3Lysine Market International (US, Europe, Japan) Research Analysis 2Lysine Market International (US, Europe, Japan) Research Analysis 3Lysine Market International (US, Europe, Japan) Research Analysis 4Lysine Market International (US, Europe, Japan) Research Analysis 5
... The American Heart Journal today reported results ... candidate, AMR-001 for the treatment of damaged heart muscle ... relationship between cell dose and biologic effect. This is ... dose of a purified and potent autologous (self-donating) stem ...
... Emisphere Technologies, Inc. (OTC Bulletin Board: EMIS ... ) today announced that they have entered into an ... oral formulations of Novo Nordisk,s insulins, which have the ... is the second license agreement between the two companies. ...
Cached Medicine Technology:Amorcyte Stem Cell Therapy Demonstrates Clinically Significant Reperfusion in Severe Heart Attack Patients 2Amorcyte Stem Cell Therapy Demonstrates Clinically Significant Reperfusion in Severe Heart Attack Patients 3Novo Nordisk A/S and Emisphere Technologies, Inc. Announce License Agreement to Develop Oral Formulation of Insulin for Diabetes 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: