Navigation Links
InteKrin Therapeutics Announces INT131 Phase 2a Results at the 2009 American Diabetes Association Annual Meeting
Date:6/10/2009

LOS ALTOS, Calif., June 10 /PRNewswire/ -- InteKrin Therapeutics Inc presented Phase 2a clinical study results at the American Diabetes Association annual meeting in New Orleans demonstrating that once a day oral treatment with INT131 provides anti-diabetic efficacy consistent with maximal dose thiazolidinedione (TZD) therapy but with less hematocrit reduction and weight gain.

The 4 week double blind placebo controlled study of INT131 in Type 2 Diabetes Mellitus (T2DM) patients previously not on pharmacological therapy showed a dose dependent decrease in fasting plasma glucose (FPG) at 4 weeks, the primary endpoint of the study. This decrease was already statistically significant at 1 week for both low and high doses (1 mg and 10 mg) of INT131.

The efficacy measured at 4 weeks of 1 mg of INT131 treatment was comparable to the efficacy modeled for this patient population treated with the maximal approved doses of Actos(R) and Avandia(R), but in contrast the low dose INT131 group did not show the significant weight gain or fluid retention (measured by hematocrit drop) modeled for maximal dose TZDs. The high dose INT131 group showed about twice the decrease in FPG attained with low dose INT131, and a correspondingly greater efficacy compared to that modeled for maximal dose TZDs. Importantly, this greater efficacy was achieved with INT131 without greater weight gain or hematocrit drop than expected for maximal dose TZDs. INT131 was well tolerated in this study with no safety issues noted.

"These data are supportive of INT131 acting as a selective modulator of PPARgamma in T2DM patients," remarked Dr Alex DePaoli, Chief Medical Officer of InteKrin Therapeutics, who presented the data. "The key observation from this study is that INT131 is a potent insulin sensitizer that lowers fasting glucose as well as the maximal dose of the TZDs while mitigating the typical side effect profile."

"Transla
'/>"/>

SOURCE InteKrin Therapeutics Inc
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. InteKrin Therapeutics Announces $20 Million Series C Financing
2. InteKrin Therapeutics, Inc. Appoints Former Amgen Clinical Development Executive Chief Medical Officer
3. Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281
4. Oxygen Biotherapeutics, Inc. Announces Private Placement Financing Agreement and Offer to Acquire Warrants
5. Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Incs. GCS-100 Molecule
6. Natura Therapeutics and USF receive NIH grant to study green tea compound for Alzheimers
7. Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis
8. Echo Therapeutics Licenses Needle-Free Prelude SkinPrep System to Ferndale Pharma for Enhanced Delivery of Topical Lidocaine
9. SXC Health Solutions announces agreements for pharmacy technology services with Prime Therapeutics LLC
10. Cephalon Acquires Controlling Interest in Arana Therapeutics
11. Cornerstone Therapeutics Announces Management Change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... Freeport, ME (PRWEB) , ... August 01, 2015 , ... ... “America’s Retail Champions.” , Wilcoxson was given that honor by the National Retail Federation, ... the retail industry. Wilcoxson was one of three Maine business owners to be named ...
(Date:8/1/2015)... ... 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe Organic Hair Care, ... small business donation to kick off the campaign for healing and Well-Being. , BeverlyD ... a complete line of raw, organic hair care products, as well as her book, ...
(Date:7/31/2015)... New York (PRWEB) , ... July 31, 2015 , ... ... strut their stuff, Super-Sod debuted their new type of sod called Leisure Time(TM) ... trademark application in process. , To commemorate introduction of this new type of sod, ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently ... know in predictive health analytics , Jvion continues to disrupt the predictive ... predictive software that targets patient and population level illness to drive prevention and ...
(Date:7/31/2015)... FL (PRWEB) , ... July 31, 2015 , ... ... announced an important workshop at its new True North Conference Center. The medical ... so that the Jacksonville community may be more aligned in the effort to ...
Breaking Medicine News(10 mins):Health News:Local Retail Advocate Wins National Recognition 2Health News:March4thforWellBeing Foundation Kickoff 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3
... Department declares a Public Health EmergencyHARRISBURG, Pa., April 27 ... with federal officials to contain the impact of an ... the declaration of a national public health emergency in ... educate the public and health care providers of recommended ...
... N.Y., APRIL 27 Whether it,s flowers Mom wants, or ... helping to make a difference for other moms and babies who ... of Dimes give every baby a healthy start in life by ... will support the March of Dimes mission.The ,Mother,s Love, necklace is ...
... But it,s unlikely these factors cause the neurological condition, experts ... older mothers and children who have breech deliveries are almost ... researchers report. , The findings confirm those of other studies ... genetic base, researchers say. , "A child with breech ...
... , Media may now register to attend TCT ... of the Cardiovascular Research Foundation. TCT gathers leading ... to present and discuss the latest developments in ... Now in its 21st year, TCT brings state-of-the-art ...
... Access to IAC for Electronic ClaimsJACKSONVILLE, Fla., April ... information network, today announced that Insurers Administrative Corporation ... of HIPAA compliant electronic claims. As an Availity ... through the Availity(R) Health Information Network free of ...
... Medical College of Georgia is part of a large ... schizophrenia and 10,000 healthy individuals in an effort to ... , Blood samples taken from each group will enable ... variations that convey individual risk for the disease that ...
Cached Medicine News:Health News:Pennsylvania Working Closely With Federal Partners to Contain Impact of Swine Flu 2Health News:Pennsylvania Working Closely With Federal Partners to Contain Impact of Swine Flu 3Health News:For Mother's Day, Show Your Love By Helping the March of Dimes Help All Moms Have Healthy Babies 2Health News:Autism Tied to Older Moms, Breech Birth 2Health News:Autism Tied to Older Moms, Breech Birth 3Health News:Media registration now open for TCT 2009 2Health News:Insurers Administrative Corporation Joins the Availity Network 2Health News:MCG participating in national study to identify genetic variants in schizophrenia 2Health News:MCG participating in national study to identify genetic variants in schizophrenia 3
(Date:7/31/2015)... 31, 2015 Egalet Corporation (Nasdaq: ... company focused on developing, manufacturing and marketing innovative ... previously announced underwritten public offering of 7,666,667 shares ... price of $11.25 per share. The shares of ... issued upon the exercise in full by the ...
(Date:7/31/2015)... CHICAGO , July 31, 2015 ... Composition Analyzers Market by Product (Bioimpedance Analyzers (BIA), Dual-Energy ... and Hydrostatic Weighing) - Global Analysis & Forecast to ... Market was pegged at $911.1 Million 2014 and is ... at a CAGR of 9.4% from 2014 to 2019. ...
(Date:7/30/2015)... 2015  ResMed (NYSE: RMD ) ... agreement to acquire Curative Medical, a privately-held ... breathing medical devices and accessories. ... leadership in sleep and respiratory medicine, will ... suffering from sleep-disordered breathing and ...
Breaking Medicine Technology:Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3
... Nov. 14, 2011 Dynex Technologies, Inc., a ... testing easier, more cost-effective, and less labor intensive, ... sample processing system at the MEDICA 2011 – ... November 16 to 19, 2011. The Agility system ...
... 11, 2011 Patients who are dependent on opioids (narcotic ... replacement surgery have much more difficulty recovering, a study ... Surgery (JBJS) has found. These patients tend ... rate of complications, and are more likely to need additional ...
Cached Medicine Technology:Dynex Technologies to Showcase Agility™ ELISA Processor at MEDICA 2011 - Hall 3, Stand D45-6 2Take Care with Pain Meds 2Take Care with Pain Meds 3
Stainless steel bone clamp....
Reduction Forceps with Points for precise reduction of bone fragments with minimal soft tissue contact....
Designed for proximal femoral elevation in total hip replacement or in other surgery with a similar need for bone manipulation....
Straight double action bone cutting rongeur....
Medicine Products: