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InteKrin Therapeutics, Inc. Appoints Former Amgen Clinical Development Executive Chief Medical Officer
Date:11/8/2007

Molecular Endocrinology at the University of Chicago with Drs. Kenneth Polonski and Graham Bell. His clinical and research interests in diabetes and obesity were focused during his work at the Sansum Diabetes Research Institute which led him to join Amgen to build the Metabolic Disease Area and direct the Leptin program. At Amgen he also directed the development of a broad array of metabolic disease targets focused on translating novel pathways into the clinic. These pathways include 11 Beta HSD-1, RANK Ligand, calcium sensing receptor, PPAR-gamma modulation, and MCH-R1. He also maintains his clinical practice.

About InteKrin (http://www.InteKrin.com):

InteKrin Therapeutics is a privately-held clinical-stage drug development company focused on diabetes and metabolic disease. InteKrin's business strategy is to build a robust portfolio of high value products by in-licensing clinical-stage therapeutic candidates that address significant unmet medical needs and rapidly move them through critical development stages under the direction of InteKrin's accomplished management team and world-class SAB. The company was co-founded by Chief Executive Denny Lanfear, a former Amgen VP and Officer, and by Scientific Advisory Board Chair Christos Mantzoros, M.D., D.Sc., a leading clinical endocrinologist and Associate Professor at Harvard Medical School. InteKrin's team of world-class scientific and medical experts includes veterans from several successful biopharma organizations, internationally recognized experts in nuclear receptors and metabolism, top scientists formerly with the Food and Drug Administration and key clinical and commercialization leaders who brought earlier PPAR agonists to market.

InteKrin's lead therapeutic candidate, INT131, is a potent non-TZD SPPARM (Selective Peroxisome Proliferator-Activated Receptor Modulator) that was specifically engineered to have equal or better efficacy to the cu
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SOURCE InteKrin Therapeutics, Inc.
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