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Insulin resistance may be associated with stroke risk
Date:10/11/2010

45 percent greater risk of any type of vascular event. However, insulin resistance was not associated with heart attack or vascular death separately.

"There are several possible reasons for the stronger effect of insulin resistance on the risk of ischemic stroke than of myocardial infarction in the present study compared within other studies," the authors write. It may be because individuals with a history of heart attack were excluded from this study, or because factors associated with insulin resistanceincluding high blood pressure, high triglyceride levels and low HDL or "good" cholesterol levelsare more significant risk factors for stroke than for heart attack.

"These findings emphasize the need to better characterize individuals at increased risk for ischemic stroke and the potential role of primary preventive therapies targeted at insulin resistance," the authors conclude.

(Arch Neurol. 2010;67[10]:1195-1200. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: This study was supported by the Gilbert Baum Memorial Grant and the Goddess Fund for Stroke Research in Women, by grants from the National Institute of Neurological Disorders and Stroke, by the Kathleen Scott Research Fellowship from the American Heart Association and a grant from the General Clinical Research Center. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Insulin Resistance Can Be Used to Refine Risk Stratification

"The implications of these findings are exciting if insulin resistance can be proven to be a causal risk factor for stroke (rather than a marker of increased risk) because insulin resistance cannot only be measured but also treated," write Graeme J. Hankey, M.D., F.R.C.P., F.R.C.P.(Edin), F.R.A.C.P., of University of Western Australia, Pe
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Contact: Lisa Worley
lworley2@med.miami.edu
305-243-5184
JAMA and Archives Journals
Source:Eurekalert

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