Insulin drug study shows significant improvements in more than 52,000 diabeti... (insulin with or without oral antidiabeti...)

Insulin drug study shows significant improvements in more than 52,000 diabetic patients

Date:3/2/2009

insulin, with or without oral antidiabetic drugs. Time since diagnosis averaged 10.4 years and HbA1c levels averaged 9.3 per cent.

"Patients are usually not started on insulin when they are diagnosed with Type II Diabetes" explains Professor Valensi. "Lifestyle changes and oral antidiabetic drugs are usually the first therapeutic steps, but some patients are unable to control their blood glucose levels using this method and insulin is the next step."

Each patient took the biphasic insulin (marketed as NovoMix 30) as directed by their clinician for 26 weeks and data was recorded on each patient at baseline, three months and at the final visit. More than 95 per cent of the patients completed the study.

Reductions in blood glucose levels were significant in all three groups. Patients who had not previously received any diabetes treatment before they were included in the study achieved the biggest HbA1c reduction, down by an average of 31 per cent.

Patients who had only received oral medication before achieved an average fall of 23 per cent and patients who had received injectable insulin, with or without oral medication, achieved an average reduction of 22 per cent.

This took their average HbA1c levels down to 6.8 per cent, 7.1 per cent and 7.3 per cent respectively, with more than half of the patients achieving the seven per cent target set by the International Diabetes Foundation.

The study in IJCP contains detailed results for the 52,419 patients from the first eight countries to complete the study Canada (1,594 patients), China (21,729), India (17,890), Japan (2,095), Poland (4,117), Russia (4,662), Greece (114) and Italy (218).

Patient demographics and clinical characteristics included:

Study participants had an average age of 55 and 57 per cent were male. They had an average body mass index of 26. Their average HbA1c (blood glucose level) was 9.3 per cent and average time sin
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Contact: Annette Whibley
wizard.media@virgin.net
Wiley-Blackwell
Source:Eurekalert

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