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Insulin drug study shows significant improvements in more than 52,000 diabetic patients
Date:3/2/2009

A major international diabetes study of more than 52,000 patients from eight countries has shown that using biphasic BIAsp 30 insulin resulted in significant clinical improvements and greater patient satisfaction.

The findings, reported in the March issue of IJCP, the International Journal of Clinical Practice, show that 53 per cent achieved a blood glucose (HbA1c) level of less than seven per cent, the target set by the International Diabetes Foundation.

Based on the largest database of Type II Diabetes patients ever compiled, the first phase of the IMPROVE study covered eight countries: Canada, China, Greece, India, Italy, Japan, Poland and Russia.

Data for the Gulf region, Iran and South Korea will be available later this year.

The study looked at the safety and effectiveness of using the biphasic insulin, which contains both fast-acting and intermediate components, prescribed by family doctors and hospital consultants.

"Patients with Type II Diabetes who used the biphasic insulin saw their blood glucose levels drop by up to 31 per cent and episodes of major hypoglycaemia, where the glucose levels become very low, fell by an average of 94 per cent" explains Professor Paul Valensi, head of the Department of Endocrinology-Diabetology-Nutrition at the Jean Verdier Hospital in France, who led the research.

"They also expressed greater satisfaction in the treatment they received, with the percentage rising from 10 per cent at baseline to 59 per cent at the end of the study."

A total of 52,419 patients were enrolled from three pre-study treatment groups:

  • 17 per cent were not receiving any antidiabetic treatment when they joined the study. Time since diagnosis averaged two years and HbA1c levels averaged 9.9 per cent.
  • 65 per cent were on oral antidiabetic drugs. Time since diagnosis averaged 7.4 years and HbA1c levels averaged 9.2 per cent.
  • 18 per cent were on injectable
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Contact: Annette Whibley
wizard.media@virgin.net
Wiley-Blackwell
Source:Eurekalert

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