Navigation Links
Insulin could be Alzheimer's therapy
Date:4/1/2011

BUFFALO, N.Y. -- A low dose of insulin has been found to suppress the expression in the blood of four precursor proteins involved in the pathogenesis of Alzheimer's disease, according to new clinical research by University at Buffalo endocrinologists. The research, published in March online in the Journal of Clinical Endocrinology and Metabolism, suggests that insulin could have a powerful, new role to play in fighting Alzheimer's disease.

"Our results show clearly that insulin has the potential to be developed as a therapeutic agent for Alzheimer's, for which no satisfactory treatment is currently available," says Paresh Dandona, MD, PhD, UB distinguished professor of medicine in the School of Medicine and Biomedical Sciences and senior author on the study.

One of the four proteins shown in the study to be suppressed by insulin is a precursor to beta amyloid, the main component of plaques considered the hallmark of Alzheimer's disease.

The findings also demonstrate for the first time that the four precursor proteins studied are expressed in peripheral mononuclear cells, white blood cells that are an important component of the immune system.

The paper builds on the UB researchers' earlier work showing that insulin has a potent and rapid anti-inflammatory effect on peripheral mononuclear cells. It also builds on the well-known association between obesity, type 2 diabetes and chronic low-grade inflammation, as well as insulin resistance, all conditions that manifest a significantly increased prevalence of Alzheimer's disease.

In the study, 10 obese, type 2 diabetic patients were infused with two 100 ml units of insulin per hour over a period of four hours. The patients were all taking oral drugs to treat their diabetes; none of them were taking insulin or any antioxidant or nonsteroidal anti-inflammatory drugs. The control group received 5 percent dextrose per hour or normal saline solution.

The low-dose insulin was found to s
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Hormone Outperforms Insulin in Diabetic Mice
2. Experts call for further research into the relationship between insulin therapy and cancer
3. More Info Needed on Problems With Insulin Pumps
4. New Inhaled Insulin Shows Promise for Diabetes
5. Jekyll and Hyde Factor May Control Insulin Function
6. Study Finds That Insulin-Producing Beta Cells Can Be Reborn
7. One Sleepless Night Ups Insulin Resistance
8. Mayo-led research team develop agents that keep insulin working longer
9. New pathway to cheap insulin
10. Nicer than needles: Insulin pills for diabetes finally in clinical trials
11. Diabetic potential to create own insulin
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insulin could be Alzheimer's therapy
(Date:9/3/2015)... DC (PRWEB) , ... September 03, 2015 , ... ... the speakers for its upcoming virtual conference, “Proven Pharmacy Benefit Strategies for a ... such as CVS Health, Express Scripts and Milliman, will discuss how plan sponsors ...
(Date:9/3/2015)... ... September 03, 2015 , ... “We wish ... can impact the delicate life balance between work and leisure to the benefit ... R. Leaptrott, CEO , A LifeMinder Plus® Emergency Care Document Set duly executed ...
(Date:9/3/2015)... ... 03, 2015 , ... Representatives with State Farm Agent EJ ... Mississippi Gulf Babypalooza on September 19, 2015. , “We will be providing information ... beyond. We will be discussing setting up college funds, offering information specific to ...
(Date:9/3/2015)... ... ... Local filmmakers and now co-hosts of the up and coming podcast Path11 ... had great success in launching their Path11 Podcast with 23 episodes released since April ... is the well known Spiritual Catalyst and Linda Howe, leader in the field of ...
(Date:9/3/2015)... ... September 03, 2015 , ... Fashion designer Kim (29 ... of the most recent episode of the hit ABC series “Extreme Weight Loss” ... image of her industry. She provided herself with the motivation to transform when she ...
Breaking Medicine News(10 mins):Health News:Speakers for Upcoming AIS Virtual Conference on Pharmacy Benefit Strategies Include Executives from CVS Health, Express Scripts 2Health News:LifeMinder Plus® Announces Emergency Care Document Set Giveaway for America 2Health News:LifeMinder Plus® Announces Emergency Care Document Set Giveaway for America 3Health News:State Farm Agent EJ Roberts to Help Expecting Mothers at the Mississippi Gulf Babypalooza 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 3Health News:New “Extreme Weight Loss” Video Blog from the CU Anschutz Health and Wellness Center: Kim Begins with the End in Mind and Designs a Fashionable Future 2Health News:New “Extreme Weight Loss” Video Blog from the CU Anschutz Health and Wellness Center: Kim Begins with the End in Mind and Designs a Fashionable Future 3
... firm, founded by veteran attorney Bruce Abel, launches blog to help ... ... Los Angeles (Lexis Nexis) May 23, 2009 -- In ... protecting workers, rights and minimize the risk of employment litigation, ...
... HAE:TSX- Loan of US$2.5 Million Expected to Close ... Haemacure Corporation (TSX:HAE), a Montreal-based specialty bio-therapeutics company, ... Vancouver (NASDAQ: ANPI , TSX:ANP) are preparing ... loan from Angiotech to Haemacure in the amount ...
... Minnesota Chiropractic Association (MCA) recognized Dr. Joseph Sweere as ... and awards ceremony Sweere was honored for his unselfish ... Sweere is a professor in the Department of Clinical ... chairman of the Department of Occupational Health at Northwestern, ...
... Breakthrough caregiver training to revolutionize senior home care ... Assistance of Palo Alto, California released its new ... Method(TM). This system, exclusive to Home Care Assistance ... North America with an emphasis on lifestyle, healthy ...
... Helen Darling, President of the National Business Group ... is the national association representing 300 large employers - ... benefits to more than 55 million Americans workers, dependents, ... responding to what we believed were some mischaracterizations in ...
... for clues to better treatments , , FRIDAY, May 22 (HealthDay ... the protein caveolin-1 found in stromal connective tissue near a ... may provide a pathway to future treatments. , Low ... absorb things, in the stromal cells were linked to a ...
Cached Medicine News:Health News:Abel Law Offices Introduces Free Web Resource for California Employers Navigating Workplace Laws 2Health News:Haemacure Update on Proposed Collaboration and Bridge Financing 2Health News:Haemacure Update on Proposed Collaboration and Bridge Financing 3Health News:Haemacure Update on Proposed Collaboration and Bridge Financing 4Health News:Haemacure Update on Proposed Collaboration and Bridge Financing 5Health News:Dr. Joseph Sweere Receives Educator of the Year Award 2Health News:Dr. Joseph Sweere Receives Educator of the Year Award 3Health News:Home Care Assistance's Exclusive Balanced Care Method(TM) Designed to Promote Longer, Healthier Lives 2Health News:Home Care Assistance's Exclusive Balanced Care Method(TM) Designed to Promote Longer, Healthier Lives 3
(Date:9/2/2015)... 2015 The quantum dot market report analyzes the ... based on the product includes medical devices, display, and others. ... battery and energy storage, QD laser, and transistor. The application ... quantum dot market. The report also provides the geographic view ... , Europe , Asia-Pacific ...
(Date:9/2/2015)... , Sept. 2, 2015   About ELISA ... most common laboratory technologies that is used for measuring ... in solution. ELISA test uses various types of enzymes ... and the result is detected by photometry or fluorometry. ... treatment of various infectious diseases such as HIV, pernicious ...
(Date:9/2/2015)... , Sept. 2, 2015 Research and Markets ( ... Regulatory Affairs in China (Basel, Switzerland - November 26-27, 2015)" ... will provide a detailed overview of the key areas of ... Hong Kong , Macau ... - All important aspects of gaining and maintaining ...
Breaking Medicine Technology:Quantum Dot Market by Product , Material, Application, and Geography- Forecast up to 2020 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 3Pharmaceutical Regulatory Affairs in China Seminar: Basel, Switzerland - November 26-27, 2015 2
... Equally Spaced, Expandable, Multichannel Pipettor ... instantly boosts productivity with an industry breakthroughequal ... adjustment of a slide rod. This innovation ... liquids between vessels with different configurations. ...
... Ergonomic Design for Unparalleled Comfort Pick one ... the balance. Notice the trigger and ejector positionsright ... because our pipettors are ergonomically designed to help ... of pipetting. Productivity In The Palm Of ...
... ergonomic solution and best value in high ... action and ultra lightweight design reduce hand ... with long, lever tip ejector , Color ... universal tips or for greater performance use ...
... ergonomic solution and best value in high ... action and ultra lightweight design reduce hand ... with long, lever tip ejector , Color ... universal tips or for greater performance use ...
Medicine Products: