Navigation Links
Insulin Resistance Tied to Peripheral Artery Disease
Date:6/16/2008

Those with highest levels at almost twice the risk, regardless of diabetes, study finds

MONDAY, June 16 (HealthDay News) -- A new study has found a strong association between insulin resistance and peripheral arterial disease (PAD), which leads to a four-to-five times increased risk of heart attack and stroke.

People with the highest levels of insulin resistance (often a precursor to diabetes) had nearly twice as much PAD, regardless of other cardiovascular risk factors such as diabetes. For each quartile of insulin resistance, the risk of PAD increased by about 25 percent.

According to the American Heart Association, PAD involves a narrowing of the arteries leading to the extremities, most notably the legs. It can cause cramping and tiredness in the limbs.

The researchers analyzed data from more than 3,200 adults enrolled in the U.S. National Health and Nutrition Examination Survey 1999-2004. They compared PAD incidence and insulin sensitivity using a model of insulin resistance (HOMA-IR), a test derived from fasting glucose and insulin values.

The overall prevalence of PAD was 5.5 percent. Insulin resistance was independently associated with PAD after the researchers adjusted for age, gender, race/ethnicity, hypertension, hyperlipidemia, smoking, body mass index, chronic kidney disease and blood levels of c-reactive protein, a marker of inflammation.

"We found a roughly 25 percent increase in the risk of PAD for each one-quartile increase in HOMA-IR, a finding that remained consistent despite adjustment for typical atherosclerosis risk factors related to insulin resistance such as body mass index and glycemic [blood sugar] control," study lead author Dr. Reena L. Pande, of the cardiovascular division at Brigham and Women's Hospital in Boston, said in a prepared statement.

"Even after excluding subjects with diabetes, there were graded increases in PAD prevalence with increasing HOMA-IR quartiles, supporting prior observations that PAD is associated with the metabolic syndrome and glucose intolerance, both surrogate markers of insulin resistance.

"Further, the association persisted after adjustment for diabetes or hemoglobin A1c, another measure of blood sugar control, indicating that insulin resistance may play a role in PAD along the entire spectrum of insulin resistance, quite distinct from the impact of diabetes," Pande said.

The study was published in the journal Circulation.

"For doctors and patients, our study highlights the role of insulin resistance in PAD and gives us a snapshot of the association between the two diseases," Pande said. "For this to play out, however, we still need prospective studies that follow over time insulin-resistant patients to determine their risk of developing PAD."

More information

The U.S. National Heart, Lung, and Blood Institute has more about peripheral arterial disease.



-- Robert Preidt



SOURCE: American Heart Association, news release, June 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Some patients may not need insulin for long-term control of type 2 diabetes
2. Novel mechanisms controlling insulin release and fat deposition discovered
3. Photo: Introduction of the Amigo Insulin Pump Offers a Lifestyle Where Life Has No Limits
4. Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
5. Disturbed regulation of insulin production
6. New nanotube sensor can continuously monitor minute amounts of insulin
7. How Patients Can Meet the Criteria for Insulin Pump Therapy
8. Once-Daily Insulin Shot Proves Effective in Study
9. Tweaking Insulin Might Help Fight Aging
10. Constant High Blood Sugar Disables Insulin Off Switch
11. Joslin study finds restricting insulin doses increases mortality risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insulin Resistance Tied to Peripheral Artery Disease
(Date:10/13/2017)... PITTSBURGH, Pa. (PRWEB) , ... October 13, 2017 , ... ... the dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a ... access to medication in darkness or restricted lighting. As such, it eliminates the need ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
(Date:10/7/2017)...   Provista, a proven leader in the ... purchasing power, today announced a new resource area on ... is the online home for case studies, articles ... news releases, slideshows and events. ... resources at their fingertips, viewers can also watch short ...
(Date:10/4/2017)... , Oct. 4, 2017 OBP ... self-contained, illuminating medical devices, today announced regulatory approval ... Surveillance Agency (or Agência Nacional de Vigilância Sanitária ... single-use, cordless surgical retractor with integrated LED light ... access, illumination and exposure of a tissue pocket ...
Breaking Medicine Technology: