Navigation Links
Insulin Resistance Tied to Peripheral Artery Disease
Date:6/16/2008

Those with highest levels at almost twice the risk, regardless of diabetes, study finds

MONDAY, June 16 (HealthDay News) -- A new study has found a strong association between insulin resistance and peripheral arterial disease (PAD), which leads to a four-to-five times increased risk of heart attack and stroke.

People with the highest levels of insulin resistance (often a precursor to diabetes) had nearly twice as much PAD, regardless of other cardiovascular risk factors such as diabetes. For each quartile of insulin resistance, the risk of PAD increased by about 25 percent.

According to the American Heart Association, PAD involves a narrowing of the arteries leading to the extremities, most notably the legs. It can cause cramping and tiredness in the limbs.

The researchers analyzed data from more than 3,200 adults enrolled in the U.S. National Health and Nutrition Examination Survey 1999-2004. They compared PAD incidence and insulin sensitivity using a model of insulin resistance (HOMA-IR), a test derived from fasting glucose and insulin values.

The overall prevalence of PAD was 5.5 percent. Insulin resistance was independently associated with PAD after the researchers adjusted for age, gender, race/ethnicity, hypertension, hyperlipidemia, smoking, body mass index, chronic kidney disease and blood levels of c-reactive protein, a marker of inflammation.

"We found a roughly 25 percent increase in the risk of PAD for each one-quartile increase in HOMA-IR, a finding that remained consistent despite adjustment for typical atherosclerosis risk factors related to insulin resistance such as body mass index and glycemic [blood sugar] control," study lead author Dr. Reena L. Pande, of the cardiovascular division at Brigham and Women's Hospital in Boston, said in a prepared statement.

"Even after excluding subjects with diabetes, there were graded increases in PAD prevalence with increasing HOMA-IR quartiles, supporting prior observations that PAD is associated with the metabolic syndrome and glucose intolerance, both surrogate markers of insulin resistance.

"Further, the association persisted after adjustment for diabetes or hemoglobin A1c, another measure of blood sugar control, indicating that insulin resistance may play a role in PAD along the entire spectrum of insulin resistance, quite distinct from the impact of diabetes," Pande said.

The study was published in the journal Circulation.

"For doctors and patients, our study highlights the role of insulin resistance in PAD and gives us a snapshot of the association between the two diseases," Pande said. "For this to play out, however, we still need prospective studies that follow over time insulin-resistant patients to determine their risk of developing PAD."

More information

The U.S. National Heart, Lung, and Blood Institute has more about peripheral arterial disease.



-- Robert Preidt



SOURCE: American Heart Association, news release, June 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Some patients may not need insulin for long-term control of type 2 diabetes
2. Novel mechanisms controlling insulin release and fat deposition discovered
3. Photo: Introduction of the Amigo Insulin Pump Offers a Lifestyle Where Life Has No Limits
4. Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
5. Disturbed regulation of insulin production
6. New nanotube sensor can continuously monitor minute amounts of insulin
7. How Patients Can Meet the Criteria for Insulin Pump Therapy
8. Once-Daily Insulin Shot Proves Effective in Study
9. Tweaking Insulin Might Help Fight Aging
10. Constant High Blood Sugar Disables Insulin Off Switch
11. Joslin study finds restricting insulin doses increases mortality risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insulin Resistance Tied to Peripheral Artery Disease
(Date:2/18/2017)... ... February 17, 2017 , ... CONTACT:, Glenn Vallecillos, ... Hills plastic surgeon Dr. Glenn Vallecillos experiments SculpSure, the hot, new, ... plastic surgery has been centered around that idea that to achieve ones desired ...
(Date:2/18/2017)... ... February 18, 2017 , ... ProParagraph Fashion ... Film Studios ’ ProParagraph Fashion Volume 2 for all multi-line FCPX project needs. ... Users can pick and choose from hand-crafted trend-setting designs with smooth animations that ...
(Date:2/17/2017)... ... February 17, 2017 , ... Smiles by Seese is ... in Davidson, NC. Dr. Brian Seese leads the practice as a skilled and highly ... one roof. Smiles by Seese serves patients of all ages with excellence in general, ...
(Date:2/17/2017)... ... February 17, 2017 , ... The Alliance Healthcare Foundation (AHF) ... further positively impact the health and wellness of our community in San Diego ... duty to seriously consider releasing our assets beyond our 5% targeted distribution each ...
(Date:2/17/2017)... ... 2017 , ... For the first time, International Scholarship and ... floor for the 2017 HIMSS Conference & Exhibition at the Orange ... than 40,000 healthcare industry professionals are expected at the conference, where they will ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... Cryoablation, Electrical, Endometrial Hydrothermal, Laser/Light, Microwave, Radiofrequency, ... technologies market is expected to grow at a CAGR of 9.4% ... expected to grow at a CAGR of 9.5% from 2017 to ... in 2026. ... this report will benefit you Read on to discover how ...
(Date:2/17/2017)... (NYSE, TASE: PRGO) today announced it has received final approval ... and homatropine methylbromide oral solution (syrup), 5 mg/1.5 mg per ... oral solution (syrup), 5 mg/1.5 mg per 5 mL is ... children 6 years of age and older. Annual sales for ...   ...
(Date:2/17/2017)... ST. LOUIS , Feb. 17, 2017   ... hospitals, has announced a new partnership with Engage ... the United States . FormFast will serve ... part of Engage,s implementations with MEDITECH .  ... that provides essential functionality to complement and enhance the ...
Breaking Medicine Technology: