Navigation Links
Insulin Resistance Tied to Peripheral Artery Disease
Date:6/16/2008

Those with highest levels at almost twice the risk, regardless of diabetes, study finds

MONDAY, June 16 (HealthDay News) -- A new study has found a strong association between insulin resistance and peripheral arterial disease (PAD), which leads to a four-to-five times increased risk of heart attack and stroke.

People with the highest levels of insulin resistance (often a precursor to diabetes) had nearly twice as much PAD, regardless of other cardiovascular risk factors such as diabetes. For each quartile of insulin resistance, the risk of PAD increased by about 25 percent.

According to the American Heart Association, PAD involves a narrowing of the arteries leading to the extremities, most notably the legs. It can cause cramping and tiredness in the limbs.

The researchers analyzed data from more than 3,200 adults enrolled in the U.S. National Health and Nutrition Examination Survey 1999-2004. They compared PAD incidence and insulin sensitivity using a model of insulin resistance (HOMA-IR), a test derived from fasting glucose and insulin values.

The overall prevalence of PAD was 5.5 percent. Insulin resistance was independently associated with PAD after the researchers adjusted for age, gender, race/ethnicity, hypertension, hyperlipidemia, smoking, body mass index, chronic kidney disease and blood levels of c-reactive protein, a marker of inflammation.

"We found a roughly 25 percent increase in the risk of PAD for each one-quartile increase in HOMA-IR, a finding that remained consistent despite adjustment for typical atherosclerosis risk factors related to insulin resistance such as body mass index and glycemic [blood sugar] control," study lead author Dr. Reena L. Pande, of the cardiovascular division at Brigham and Women's Hospital in Boston, said in a prepared statement.

"Even after excluding subjects with diabetes, there were graded increases in PAD prevalence with increasing HOMA-IR quartiles, supporting prior observations that PAD is associated with the metabolic syndrome and glucose intolerance, both surrogate markers of insulin resistance.

"Further, the association persisted after adjustment for diabetes or hemoglobin A1c, another measure of blood sugar control, indicating that insulin resistance may play a role in PAD along the entire spectrum of insulin resistance, quite distinct from the impact of diabetes," Pande said.

The study was published in the journal Circulation.

"For doctors and patients, our study highlights the role of insulin resistance in PAD and gives us a snapshot of the association between the two diseases," Pande said. "For this to play out, however, we still need prospective studies that follow over time insulin-resistant patients to determine their risk of developing PAD."

More information

The U.S. National Heart, Lung, and Blood Institute has more about peripheral arterial disease.



-- Robert Preidt



SOURCE: American Heart Association, news release, June 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Some patients may not need insulin for long-term control of type 2 diabetes
2. Novel mechanisms controlling insulin release and fat deposition discovered
3. Photo: Introduction of the Amigo Insulin Pump Offers a Lifestyle Where Life Has No Limits
4. Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
5. Disturbed regulation of insulin production
6. New nanotube sensor can continuously monitor minute amounts of insulin
7. How Patients Can Meet the Criteria for Insulin Pump Therapy
8. Once-Daily Insulin Shot Proves Effective in Study
9. Tweaking Insulin Might Help Fight Aging
10. Constant High Blood Sugar Disables Insulin Off Switch
11. Joslin study finds restricting insulin doses increases mortality risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insulin Resistance Tied to Peripheral Artery Disease
(Date:10/13/2017)... ... , ... Lori R. Somekh, founder of the Law Office of Somekh ... law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up ... network with elder law attorneys nationwide,” said Somekh. , ElderCounsel was ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 2017  South Korean-based healthcare product Development Company I.M. ... on Kickstarter. The device will educate the user about ... better efficiency compared to the dated and pricey CPR ... efficacy of the compression for a more informed CPR ... to raise $5,000. ...
(Date:10/2/2017)... Lilly and Company (NYSE: LLY ) will ... 2017 on Tuesday, October 24, 2017. Lilly will also ... investment community and media to further detail the company,s ... at 9 a.m. Eastern time. Investors, media and the ... conference call through a link that will be posted ...
Breaking Medicine Technology: