Navigation Links
Insulin May Protect Against Alzheimer's
Date:2/3/2009

In lab study, diabetes treatments are found to slow damage

TUESDAY, Feb. 3 (HealthDay News) -- Insulin may slow or prevent the memory loss caused by Alzheimer's disease, a new study says.

Laboratory research led by a team from Northwestern University found that insulin acts as a shield that deflects the toxic proteins that attack the wiring in the brain responsible for forming memories.

"Therapeutics designed to increase insulin sensitivity in the brain could provide new avenues for treating Alzheimer's disease," William L. Klein, a researcher in Northwestern's Cognitive Neurology and Alzheimer's Disease Center and senior author of the study, said in a news release issued by the school. "Sensitivity to insulin can decline with aging, which presents a novel risk factor for Alzheimer's disease. Our results demonstrate that bolstering insulin signaling can protect neurons from harm."

The findings also add to recent evidence that has some researchers considering Alzheimer's a form of diabetes. The report was published online Feb. 2 in Proceedings of the National Academy of Sciences.

In the study, insulin and rosiglitazone (Avandia)-- an insulin-sensitizing drug used to treat type 2 diabetes -- offered protection to neurons taken from the hippocampus, one of the brain's crucial memory centers. It protected the neurons from amyloid beta-derived diffusible ligands, or ADDLs, which are proteins that are known to attach to and block memory-forming synapses, leading to memory loss.

ADDLs have been found to have a role in Alzheimer's.

"The discovery that anti-diabetic drugs shield synapses against ADDLs offers new hope for fighting memory loss in Alzheimer's disease," lead author Fernanda G. De Felice, a former visiting scientist in Klein's lab and an associate professor at the Federal University of Rio de Janeiro, Brazil, said in the same news release.

The researchers had recently found, in related work, that ADDL caused insulin resistance in the neurons it binds to by stripping the insulin receptors.

More information

The Alzheimer's Association has more about Alzheimer's disease.



-- Kevin McKeever



SOURCE: Northwestern University, news release, Feb. 2, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Intensive Insulin Therapy Reduces Mortality in Sick Kids
2. High insulin levels raise risk of breast cancer in postmenopausal women
3. High Insulin May Boost Odds of Breast Cancer
4. Vitamin K Slows Insulin Resistance in Older Men
5. Vitamin K linked to insulin resistance in older men
6. Lilly Announces Major Donation of Insulin to International Diabetes Federations Life for a Child Program; Initial Focus Will Be on Sub-Saharan Africa
7. Completely novel action of insulin unveiled
8. Impact of insulin pump under study
9. Diabetes Spectrum Reports a Study Assessing the i-port(R) Injection Port for Administration of Insulin
10. Pancreatic Cells Turned Into Insulin-Producing Beta Cells
11. New survey explores the impact of insulin injections on people with diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insulin May Protect Against Alzheimer's 
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... On ... as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle ... honor of the city’s history as home to some of the world’s leading providers ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
(Date:6/23/2016)... 23, 2016  Guerbet announced today that it has ... Horizon Award . One of 12 suppliers ... for its support of Premier members through exceptional local ... and commitment to lower costs. ... of our outstanding customer service from Premier," says ...
(Date:6/23/2016)... Tenn. , June 23, 2016 /PRNewswire/ ... automating, integrating and transforming the patient payment ... of several innovative new products and services ... of its revenue cycle offerings. These award-winning ... more efficient workflows, remain compliant in an ...
Breaking Medicine Technology: