Navigation Links
Instead of fighting breast cancer, immune cell promotes its spread
Date:4/22/2009

Researchers at the UC San Diego School of Medicine and the Moores UCSD Cancer Center have new evidence that a type of immune system cell thought to be part of the first line of defense against breast cancer may also help promote its spread. They have found that when these cells, known as lymphocytes, make an inflammatory protein called RANKL (RANK ligand), breast cancer is more likely to spread to the lungs.

They have also shown that blocking a cascade of cellular signals that follow RANKL's docking to its receptor (RANK) on tumor cells can halt cancer progression, or metastasis, and may be a possible target for drug therapy.

The scientists, led by first author Wei Tan, PhD, a postdoctoral fellow in the Department of Pharmacology at the UC San Diego School of Medicine and Michael Karin, PhD, professor of pharmacology in UCSD's Laboratory of Gene Regulation and Signal Transduction, say that the findings establish RANKL as a potential marker that can be used to help determine breast cancer prognosis and adds further proof to the potentially important role of inflammation in cancer development and spread. They reported their findings April 22, 2009 at the AACR 100th Annual Meeting 2009 in Denver.

According to Tan, the role of lymphocytes in breast cancer progression has been controversial for the last 20 years. Such cells are supposed to detect and eliminate cancer cells, but paradoxically, the infiltration of lymphocytes such as B cells and T cells into breast cancer is sometimes an indicator of poor prognosis, including cancer recurrence and metastasis. RANKL has been shown in previous studies to be an important inflammatory protein that can lead to bone loss by activating cells that help break down bone. Along with another protein, IKK alpha, it has been implicated both in tumor formation and metastasis.

The researchers created two types of mice that developed breast tumors. One group had lymphocytes in the tumors and expre
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Protein thought to promote cancer instead functions as a tumor suppressor
2. Dr. Paul M. Parker Is Pioneering New Advanced Lipoabdominoplasty Instead of Traditional Tummy Tuck in New Jersey
3. Home Instead Senior Care Chooses Microsoft Dynamics CRM as Sales and Marketing Platform
4. Study shines more light on benefit of vitamin D in fighting cancer
5. Cities Say Restaurant Nutrition Information Crucial in Fighting Obesity
6. Elliot Yamin: Fighting Diabetes
7. Their immune cells, fighting your cancer
8. Clean Hands are Key to Fighting Cold, Flu Germs
9. Fighting the Gassy Effects of Good Eating, From the Harvard Health Letter
10. Family Infighting Hurts the Heart
11. The Power of Community in Fighting HIV/AIDS Among Latinos
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... According to a recent study ... a connection between women with high levels of a ... doctors have theorized about the role stress plays in ... provide scientific support. , “Stress, if very significant, can ... Barmat, an OB/GYN who specializes in reproductive endocrinology and ...
(Date:7/14/2014)... Last month Bromell Agency officially launched the new ... more detailed information on how clients can protect and ... boats in the state of Louisiana. , The agency ... website in order to better educate clients on the ... the website, which is to display comprehensive insurance information ...
(Date:7/14/2014)... 14, 2014 There’s an old adage that ... The Lash Palette say the products offered in their ... , “You can reserve The Lash Palette for $40,” said ... Store . , Paris explained that the first 1,000 have ... 21. , She went on to point out that her ...
(Date:7/14/2014)... 2014 Seven promising startup companies ... problems have been accepted into the University ... (DHA). , The awardees were selected from ... process. They include Biomeme, Fitly, Life Patch, Curbside ... France) and Pulse InfoFrame (from Canada) —both of ...
(Date:7/14/2014)... 2014 Jordan Valley Medical Center is ... comprehensive cancer center set to open by the fall ... only hospital west of I-15 in the Salt Lake ... Additionally, Jordan Valley Medical Center has partnered with Elekta, ... planning systems for radiation therapy, radiosurgery and brachytherapy, to ...
Breaking Medicine News(10 mins):Health News:Abington Health Physician Addresses Link Between Stress and Infertility 2Health News:Abington Health Physician Addresses Link Between Stress and Infertility 3Health News:The Lash Palette Preorder Event Has Officially Begun 2Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 2Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 3Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 4Health News:Jordan Valley Medical Center Set to Break Ground with New $10 Million Cancer Center 2
... day to day life. Keeping fit costs hardly anything if ... a gym or health club,// you'll be familiar with high ... These items typically cost thousands of dollars and might be ... But you can get the same results practically for free, ...
... lasers help remove lines and wrinkled from age and ... can take its toll in later years in terms ... But, says Dr Arielle Kauvar, a dermatologist at New ... smoother, firmer appearance. ,These lasers score over ...
... of botulinum toxin eases hand spasticity among stroke survivors. Spasticity ... and it causes much disability,// because it interferes with activities ... botulinum toxin - a substance that relieves muscle tightness - ... large trial of botulinum toxin (also known as botox) in ...
... may be combined with tumor growth in mice. At ... or similar pain medications will lead to increased cancer ... further studies for managing cancer pain. ,Researchers ... of morphine, similar to doses given to cancer patients ...
... potency can be influenced by various reasons. Many advertisments ... impotence to the attention of thousands of people.// Impotence ... men are taking help, particularly as large segments of ... range from 12 million to 30 million men in ...
... An acid found naturally in the body can block the ... There is no cure for Huntington's disease (HD), which is ... But researchers at the University of Texas may be one ... with HD. ,The mice were treated with a ...
Cached Medicine News:Health News:Many factors influence sexual potency 2
(Date:7/14/2014)... 2014  More than any other generation, Millennials born in ... -- but their eyes don,t. These mobile devices demand a ... the eye has not evolved to cope with them. The ... do comfortably often results in tired eyes, focusing problems, headaches ... Strain. Now ZEISS has invented a new type of lens ...
(Date:7/14/2014)... July 14, 2014  Today, ATS Labs, Inc. (ATS), ... acquired the assets of MicroTest Labs, Inc. (MTL) of ... MTL is the first step in the strategy of ... platform to support the medical device and biopharmaceutical industries. ... Accuratus Lab Services , a name that personifies the ...
(Date:7/14/2014)... , July 14, 2014  Mallinckrodt plc (NYSE: ... QCOR ) today announced that the registration statement on Form ... by Mallinckrodt plc on May 16, 2014 and amended on ... Mallinckrodt and Questcor that also constitutes a prospectus of Mallinckrodt, ... on Form S-4 is available on the SEC,s EDGAR system, ...
Breaking Medicine Technology:New Eyeglass Lens Helps Our Eyes Keep Up with our Digital Lives 2New Eyeglass Lens Helps Our Eyes Keep Up with our Digital Lives 3ATS Labs, Inc. Announces the Acquisition of MicroTest Labs, Inc. 2ATS Labs, Inc. Announces the Acquisition of MicroTest Labs, Inc. 3Mallinckrodt Pharmaceuticals And Questcor Pharmaceuticals Provide Update On Transaction 2Mallinckrodt Pharmaceuticals And Questcor Pharmaceuticals Provide Update On Transaction 3Mallinckrodt Pharmaceuticals And Questcor Pharmaceuticals Provide Update On Transaction 4Mallinckrodt Pharmaceuticals And Questcor Pharmaceuticals Provide Update On Transaction 5Mallinckrodt Pharmaceuticals And Questcor Pharmaceuticals Provide Update On Transaction 6Mallinckrodt Pharmaceuticals And Questcor Pharmaceuticals Provide Update On Transaction 7
... and women infected with HIV reduced the risk of ... of oral antiretroviral therapy (ART), according to findings from ... Prevention Trials Network (HPTN), a global partnership dedicated to ... and structural interventions. The study, known ...
... May 12, 2011 Alma Lasers Ltd., a ... aesthetic treatment devices, today announced the launch of ... for aesthetic fractional laser resurfacing. ... iPixelEr—each feature Alma,s roller-style technology which delivers fast, ...
Cached Medicine Technology:Initiation of Antiretroviral Treatment Protects Uninfected Sexual Partners from HIV Infection (HPTN Study 052) 2Initiation of Antiretroviral Treatment Protects Uninfected Sexual Partners from HIV Infection (HPTN Study 052) 3Initiation of Antiretroviral Treatment Protects Uninfected Sexual Partners from HIV Infection (HPTN Study 052) 4Initiation of Antiretroviral Treatment Protects Uninfected Sexual Partners from HIV Infection (HPTN Study 052) 5Alma Lasers Introduces the iPixel Fractional Ablative Technology 2
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
... ThumbFit™ reduces joint instability without disturbing ... remarkably comfortable and easy for users ... CHT and Robert V. Sypher Jr., ... in response to patients' complaints of ...
... the MP joint and the CMC joint of the ... both of the thumb joints. An excellent choice for ... who need maximum mobility for daily activities. Ideal for ... and for those with pain due to repetitive stress. ...
... molded from rigid plastic in a distinctive design ... comfort. The uniquely sculpted distal trim line ... maximum function of the hand. This is ... and sprains of the MCP joint, basal joint ...
Medicine Products: