Navigation Links
Inspire Medical Systems Completes $17 Million Series B Financing
Date:6/8/2009

Second generation implantable device utilizes electrical stimulation to prevent airway closure during sleep

MINNEAPOLIS, June 8 /PRNewswire/ -- Inspire Medical Systems, Inc., a private medical device company, today announced it has completed a Series B financing of $17 million. Earlier in 2009, Inspire announced the first human implant of its Inspire II system designed to treat Obstructive Sleep Apnea (OSA). Since this announcement, Inspire continued to implant patients into parallel clinical trials being conducted in the United States and in Europe with several implants in each location to date.

Synergy Life Science Partners were the lead investors. Other participants in the round included existing investors Kleiner Perkins Caufield & Byers, US Venture Partners, Medtronic, Inc., and Dr. Glen D. Nelson through GDN Holdings. The Series B financing is over two phases with the primary purpose to fund the on-going clinical activity.

It is estimated that one in fifteen adults has moderate to severe OSA(1). People with OSA experience recurrent blockage of their upper airway during sleep, resulting in frequent arousals from sleep and reduced oxygen levels in the blood. This happens in patients with OSA because the muscles that normally hold the airway open during wakefulness relax during sleep and allow the airway to collapse. When the airway is partially closed and/or the muscles relax too much, inhalation can completely close the airway, resulting in an obstructive sleep apnea event. Depending on the degree of severity, OSA is a potentially life-threatening condition. According to a recent report(2) from the National Center on Sleep Disorders Research and the National Institute of Health, someone who has undiagnosed or is non-compliant to treatment of their sleep apnea is significantly more likely to have a heart attack, a stroke, cardiac arrest during sleep, or a harmful accident.

"We are pleased to be part of the clinical trial of the Inspire system," said Tucker Woodson, M.D., Medical College of Wisconsin in Milwaukee. "There is a significant unmet need today for a device therapy that can be used consistently and effectively by patients with obstructive sleep apnea."

The Inspire system is an implantable device that delivers electrical stimulation to prevent the closure of the upper airway that can stop airflow in patients with OSA. The device is a unique closed-loop system that is able to sense respiratory effort and deliver stimulation to keep the airway open and breathing normal.

About the Inspire System

The Inspire system consists of an implantable pulse generator, a respiration pressure sensor and a stimulation lead that delivers the electrical impulses to the patient's hypoglossal nerve. The hypoglossal nerve is the twelfth cranial nerve that is located along the side of the neck and leads to the tongue. The unique closed-loop design of the Inspire system senses a patient's respiratory effort during sleep and provides hypoglossal nerve stimulation to maintain an open airway synchronous with respiration. Patients have a programming device that is used to turn the device on at bedtime and to turn the unit off during non-sleep periods. The stimulation delivered is sufficient enough to evoke a response from the nerve but at a low enough level to not disturb the patient's sleep. A physician controller unit, used during visits to the patient's treating physician, is used to monitor the therapy and make adjustments to the device as needed for the patient's unique physiology.

About Inspire Medical Systems: www.inspiremedicalsystems.com

Inspire Medical Systems, Inc., based in Minneapolis, Minnesota, was created to be the world's leading provider of innovative and cost-effective implantable therapeutic devices for the treatment of Obstructive Sleep Apnea. The focus for the company is developing and commercially releasing the Inspire system for the treatment of Obstructive Sleep Apnea (OSA). The company was formed when the intellectual property for the Inspire System was licensed and spun out from Medtronic in 2007. Financing has been provided by blue-chip venture investors Kleiner Perkins Caufield & Byers, U.S. Venture Partners, Synergy Life Science Partners, and Glen D. Nelson, M.D., through GDN Holdings. Medtronic also invested in the company and maintains a minority ownership position. The leadership team of Inspire Medical Systems oversaw the development of the technology at Medtronic and managed the successful spin-out of the program as an independent enterprise.

(1) (Caples et al, Ann Intern Med. 2005;142:187-197)

(2) (Quan et al, Circulation, 2004;109:951-957)


'/>"/>
SOURCE Inspire Medical Systems, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Ironman Competitor with Diabetes Inspires Individuals with Diabetes to Live Without Limits
2. Inspire Your Children To Become Germ-Fighters
3. A Visit With Mother Theresa in Calcutta Thirty Years Ago Inspires Dr. Puff, Clinical Psychologist, to Give Away his Books Free of Charge
4. Success of Colorful School Supply Collection Inspired by Leukemia Patient Kicks off Second Year
5. Inspired by His Mothers Financial Hardship, Author Strives to Help Women Avoid Similar Mistakes
6. Miniature Dachshunds Legacy Inspires YourDogHealth.com to Help Other Canines
7. Celebrating UC Success Contest Seeks to Educate and Inspire Ulcerative Colitis Patients
8. L.A.s Newest Advanced Imaging Center Houses New GE 64-Slice PET/CT and 3T MRI in Spa-Inspired Environment
9. Inspired Cancer Survivor Launches Customized Hair Replacement Techniques at Award-Winning Hair Salon
10. Inspire Medical Systems Completes First Implant of the Inspire II System to Treat Obstructive Sleep Apnea
11. Cherokee Inspired Comfort Awards Program Call for Nominations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... The number of chronically and ... – meaning that there is an urgent need for highly skilled care managers and ... delivering a multi-pronged approach to train and retain care managers, and enhance their skills. ...
(Date:4/28/2016)... ... April 28, 2016 , ... The Dentists Insurance Company ... signed a letter of intent with Moda to acquire Dentists Benefits ... , Started by dentists 36 years ago, TDIC focuses exclusively on supporting the ...
(Date:4/28/2016)... ... April 28, 2016 , ... Head Over Heels Athletic Arts’ gymnast, Brooklyn ... competition will be held at the University of Montana on April 28-May 1. Varize ... Mississippi River. , In order to qualify, Varize needed to place top seven all-around ...
(Date:4/28/2016)... LIVONIA, MICH. & WASHINGTON, D.C., (PRWEB) , ... ... ... nation’s largest Catholic health systems, and the Campaign for Tobacco-Free Kids, a leading ... a new partnership to promote federal, state and local policies that can help ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... Infrastructure Management solutions, announces today the availability of its latest software release, ... of capacity management and optimization, providing new analytical capabilities that assess complex ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016 Transparency Market Research ... Market - Global Industry Analysis, Size, Share, Growth, Trends, ... the global skincare devices market was valued at US$ ... at a CAGR of 10.1% from 2015 to 2023 ... Browse the full Skincare Devices Market (Treatment Device - LED ...
(Date:4/27/2016)... 27, 2016  Bayer Animal Health today announced ... the University of Florida College of Veterinary Medicine, ... in Communication Award (BECA). Brittany was selected from ... a total of $70,000 in scholarship funds through ... Bayer has provided a total of $232,500 in ...
(Date:4/27/2016)... , April 27, 2016 ... ), a developer of a new generation of ... positive overall survival results for Paclical/Apealea in the ... 789 patients with epithelial ovarian cancer. These preliminary ... Paclical/Apealea in combination with carboplatin versus Taxol in ...
Breaking Medicine Technology: