Navigation Links
Insights into cell movement likely to aid immune study, cancer research
Date:1/8/2008

St. Louis, Jan. 7, 2007 Scientists at Washington University School of Medicine in St. Louis have used yeast cells to better understand a collection of proteins associated with the formation of actin networks, which are essential to cell movement.

The cell's ability to move is important to a broad range of biomedical concerns, including understanding how immune system cells pursue disease-causing invaders and how metastasizing cancer cells migrate from a tumor.

"One of the bad things that cancer cells do is to walk away from where they're supposed to be," says senior author John Cooper, M.D., Ph.D., professor of cell biology and physiology. "If they didn't walk away, cancer would be something that you could just cut out, and that would be the end of it. So one hope is that if we learn more about how cancer cells are moving, we can someday try to block that process."

The study appears this month in Public Library of Science Biology.

In yeast, the proteins Cooper's lab studied regulate actin networks' contributions to a process called endocytosis. Yeast cells use this process to take in materials from their surface by forming pits on their cell membrane. Actin networks provide the push that forms these pits and drives them into the cell.

In more complex cells like those found in humans, the proteins have additional responsibilities that include helping regulate a process that cells use to thrust themselves forward. That process assembles many thin branching filaments of a polymer, actin, on the cell's surface. As these growing filaments reach nearby structures, they exert force that propels the cell in the desired direction.

Scientists know all the ingredients of actin networks, but they don't fully understand how the cell regulates their construction.

"One of the critical steps in generating an actin network is generating the seed of a new filament," says first author Brian Galletta, Ph.D., a postd
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New insights into common knee injuries
2. SIV infection of natural hosts provides new insights into HIV disease complexity
3. Mothers Blood Could Offer Insights Into Fetal Health
4. Study Offers Insights Into Sensory Perceptions
5. Uncover Key Competitive Intelligence Insights in Webinars Hosted by Best Practices
6. Studies lend insights into colorectal cancer screening
7. Influenza: Insights into cell specificity of human vs. avian viruses
8. Cell Insights Could Bring Better Drugs
9. New insights into inflammation in osteoarthritis
10. Physics provides new insights on cataract formation
11. Cell Insights May Predict Breast Cancers Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... in Boston, eating three or more servings of whole grain ... type 2 diabetes. They studied more than 40,000 men who ... day. They compared those men to men who ate less ... In the men who had high whole grain intakes, researchers ...
... can lower cholesterol and omega 3s improve arterial elasticity, henceforth ... the soy protein and omega 3 fatty acids. Soy protein ... in fish, //flax seed and some nuts, long have been ... produce physiological effects that benefit blood flow. ,David Jenkins, ...
... with sleep-disordered breathing suffer from behavioral and emotional ... improvement in behavior and quality of life after ... preschool and school-aged children suffer from pediatric obstructive ... is often associated with nighttime breathing difficulties and ...
... According to a recent study, infants as young as even ... make eye contact. Teresa Farroni, study's lead author, doubts that ... early in life as a survival necessity. Farroni is a ... the School of Psychology at Birkbeck College, University of London.// ...
... international Human Genome Project (HGP) have identified chromosomes which ... genes.Out of 23 pairs of human chromosomes, 3 are ... 20 years the research at the Wellcome Trust's Sanger ... impact on treating all kinds of major ailments// ranging ...
... researchers found that nearly three-quarters use some kind of ... that could thwart their prescription medications. Kline-Rogers, at the ... seem to be turning to alternative therapies even more ... mainstream drugs too.// ,"But they may not know ...
Cached Medicine News:Health News:Soy, Omega 3s convalesce artery health 2Health News:Soy, Omega 3s convalesce artery health 3Health News:Tonsillectomy improves quality of life 2Health News:Newborns Know how to make eye contact 2Health News:Heart Patients Use Alternative Medicine 2
(Date:12/15/2014)... BOSTON , December 15, 2014 ... discovery and development company, is pleased to announce the ... United States relating to its GPCR-focused drug ... US significantly strengthens the global patent estate covering Heptares, ... The suite of patents recently granted by the ...
(Date:12/13/2014)... , Dec. 12, 2014  Radiologists can transmit ... images, to their referring physicians, electronic health records ... carefully selected technology.  That was ... Systems Corporation (ADS) at the recent Radiology Society ... transmitting of radiology reports in this manner also ...
(Date:12/13/2014)... and INDIANAPOLIS , Dec. 12, ... and Chip Ganassi Racing Teams (CGRT), today announced a multi-year ... the primary sponsor of the No. 83 Novo Nordisk Chip ... the Verizon IndyCar Series. Kimball, 29, from ... only licensed driver with diabetes in the history of INDYCAR ...
Breaking Medicine Technology:Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 4Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 5Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 6Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 7
... August 27 , - Oralair(R) Grasses 300IR Highly ... Allergen Challenge Chamber, Stallergenes S.A. announces the highly ... Challenge Chamber (ACC)., The study on Oralair(R) Grasses ... different treatment durations: 1 week, 1 month,2 and 4 ...
... INDIANAPOLIS, Aug. 26 Semafore Pharmaceuticals Inc.,announced data ... in Cancer in Washington, D.C., showing additional antiangiogenic,activity ... both VEGF and Bv8 signaling., PI3K is ... /mTOR pathway that,has been shown to play a ...
Cached Medicine Technology:Stallergenes: New Study VO 56 Highly Positive Results Conducted in an Allergen Challenge Chamber 2Stallergenes: New Study VO 56 Highly Positive Results Conducted in an Allergen Challenge Chamber 3SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines 2SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines 3
... the art in inverted microscopy from Zeiss. ... range of ICS objectives, with innovative condensers ... an unusual scope of sophisticated documentation and ... designed. And Axiovert 200 M, fully motorized, ...
... TS100 is an innovative and efficient ... tool complements any research facility. Improved ... Nikon offers the TS100 binocular and ... model comes with a photo port ...
... direct digital output. Three-chip color camera for ... array of high-quality color video cameras give ... you need for an efficient viewing experience. ... image of your specimen that can be ...
... Tech GT-Capture digital camera photomicrographic system can ... such as Olympus, Leica, Nikon, and Zeiss, ... transferring images over the Internet easy and ... a performance-proven Nikkor lens. The system records ...
Medicine Products: