Navigation Links
Insights into cancer earn Premier's Award Commendation
Date:6/4/2008

WEHI's Dr Priscilla Kelly has been honoured with a Commendation in this year's Premier's Award for Medical Research. Dr Kelly is currently a Postdoctoral Fellow and was previously a PhD student in WEHI's Molecular Genetics of Cancer Division. Premier John Brumby presented Priscilla with the Commendation at a ceremony at Government House on 4 June. Dr Kelly's research has focused on two key aspects of cancer biology. First, identifying the genes that enable cells that are becoming cancerous to survive; and second, examining the role of rare stem cells in sustaining the uncontrolled growth of malignant tumours.

The first of her discoveries involves "apoptosis", the biological process by which cells destroy themselves when they are old, damaged or no longer needed. Unfortunately, if this healthy process of cell death is disrupted, the cells that escape self-destruction can instead live on, multiply and form tumours. Dr Kelly discovered that Bcl-x, a protein that inhibits apoptosis, is essential for cancer formation. She unexpectedly found that inactivation of the Bcl-x gene prevented lymphoma development in tumour-prone mice. This finding indicated that cells becoming cancerous use Bcl-x to avoid apoptosis and thereby to extend their lifespan. This discovery has important implications for understanding how cancers develop. It also suggests that prospective new drugs that target Bcl-x could be effective in killing tumour cells.

In other notable work, Dr Kelly showed that in several types of leukaemia the frequency of cells sustaining tumour growth is very high. This discovery runs counter to the widely held belief that tumours are sustained only by a rare sub-population of their cells, called "cancer stem cells." Her finding indicates that effective cancer therapy requires the destruction not only of that rare sub-population but indeed of all the leukaemic cells. This discovery underlines the need to develop cancer therapies that destroy all the cell types within a tumour.

Reflecting on the significance of Dr Kelly's research and her Premier's Award Commendation, the Director of WEHI, Professor Suzanne Cory, said, "We are delighted by the recognition of these intriguing findings by Priscilla Kelly and her WEHI colleagues. Their contributions to understanding how cancers arise and are maintained should eventually help to guide the development of better cancer therapies."


'/>"/>

Contact: Brad Allan
allan@wehi.edu.au
61-393-452-345
Research Australia
Source:Eurekalert

Related medicine news :

1. New insights into common knee injuries
2. SIV infection of natural hosts provides new insights into HIV disease complexity
3. Mothers Blood Could Offer Insights Into Fetal Health
4. Study Offers Insights Into Sensory Perceptions
5. Uncover Key Competitive Intelligence Insights in Webinars Hosted by Best Practices
6. Studies lend insights into colorectal cancer screening
7. Influenza: Insights into cell specificity of human vs. avian viruses
8. Cell Insights Could Bring Better Drugs
9. New insights into inflammation in osteoarthritis
10. Physics provides new insights on cataract formation
11. Cell Insights May Predict Breast Cancers Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... 07, 2016 , ... “The Road To Restoration”: an informative and enlightening ... hour a week showing of hands. “The Road To Restoration” is the creation of ... familiar with the brass ring that you could reach out for, and grab, on ...
(Date:12/7/2016)... ... 07, 2016 , ... “Fred Rides a Train” allows readers to tag along ... “Fred Rides a Train” is the creation of published author, Janet Morrison, who has ... in Michigan. The "Fred, the Dog" series is her first attempt at writing for ...
(Date:12/7/2016)... WI (PRWEB) , ... December 07, 2016 , ... ... Labs, was honored to present at the International Probiotic Association’s Washington DC workshop ... and government regulators to engage in dialog regarding probiotic dietary supplement regulations. ...
(Date:12/6/2016)... ... December 06, 2016 , ... People ... can be seen on a type of MRI, according to a study appearing ... of the central nervous system characterized by tremors or trembling and stiffness in ...
(Date:12/6/2016)... ... December 06, 2016 , ... Individuals who seek to reduce ... drinking more water or limiting their exposure to the sun, according to a November ... group Beverly Hills Physicians (BHP) notes that, while preventive measures to help keep ourselves ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7, 2016  Varian Medical Systems (NYSE: ... its previously announced plans to separate its Imaging Components ... a tax-free distribution to Varian stockholders of common stock ... that will hold the Imaging Components business.  As part ... executed by the end of January 2017, Varian will ...
(Date:12/7/2016)... , Dec. 7, 2016 Boehringer ... trial in patients with unresectable malignant pleural mesothelioma ... (PFS). The data, presented at the 17 th ... Vienna , showed nintedanib plus ... placebo plus pemetrexed/cisplatin, with a significantly improved PFS ...
(Date:12/7/2016)... , Dec. 7, 2016  Organovo Holdings, Inc. ... biology company focused on delivering scientific and medical ... that Chairman and Chief Executive Officer Keith ... on Wednesday, December 14, 2016 at 1:00 p.m. ... are not yet familiar with the Company, an ...
Breaking Medicine Technology: