Navigation Links
Insights into cancer earn Premier's Award Commendation
Date:6/4/2008

WEHI's Dr Priscilla Kelly has been honoured with a Commendation in this year's Premier's Award for Medical Research. Dr Kelly is currently a Postdoctoral Fellow and was previously a PhD student in WEHI's Molecular Genetics of Cancer Division. Premier John Brumby presented Priscilla with the Commendation at a ceremony at Government House on 4 June. Dr Kelly's research has focused on two key aspects of cancer biology. First, identifying the genes that enable cells that are becoming cancerous to survive; and second, examining the role of rare stem cells in sustaining the uncontrolled growth of malignant tumours.

The first of her discoveries involves "apoptosis", the biological process by which cells destroy themselves when they are old, damaged or no longer needed. Unfortunately, if this healthy process of cell death is disrupted, the cells that escape self-destruction can instead live on, multiply and form tumours. Dr Kelly discovered that Bcl-x, a protein that inhibits apoptosis, is essential for cancer formation. She unexpectedly found that inactivation of the Bcl-x gene prevented lymphoma development in tumour-prone mice. This finding indicated that cells becoming cancerous use Bcl-x to avoid apoptosis and thereby to extend their lifespan. This discovery has important implications for understanding how cancers develop. It also suggests that prospective new drugs that target Bcl-x could be effective in killing tumour cells.

In other notable work, Dr Kelly showed that in several types of leukaemia the frequency of cells sustaining tumour growth is very high. This discovery runs counter to the widely held belief that tumours are sustained only by a rare sub-population of their cells, called "cancer stem cells." Her finding indicates that effective cancer therapy requires the destruction not only of that rare sub-population but indeed of all the leukaemic cells. This discovery underlines the need to develop cancer therapies that destroy all the cell types within a tumour.

Reflecting on the significance of Dr Kelly's research and her Premier's Award Commendation, the Director of WEHI, Professor Suzanne Cory, said, "We are delighted by the recognition of these intriguing findings by Priscilla Kelly and her WEHI colleagues. Their contributions to understanding how cancers arise and are maintained should eventually help to guide the development of better cancer therapies."


'/>"/>

Contact: Brad Allan
allan@wehi.edu.au
61-393-452-345
Research Australia
Source:Eurekalert

Related medicine news :

1. New insights into common knee injuries
2. SIV infection of natural hosts provides new insights into HIV disease complexity
3. Mothers Blood Could Offer Insights Into Fetal Health
4. Study Offers Insights Into Sensory Perceptions
5. Uncover Key Competitive Intelligence Insights in Webinars Hosted by Best Practices
6. Studies lend insights into colorectal cancer screening
7. Influenza: Insights into cell specificity of human vs. avian viruses
8. Cell Insights Could Bring Better Drugs
9. New insights into inflammation in osteoarthritis
10. Physics provides new insights on cataract formation
11. Cell Insights May Predict Breast Cancers Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... , ... January 20, 2017 , ... “The Angel”: ... Lord has set out for each of his children. “The Angel” is the creation ... of Music in New York City, and impassioned writer. , When asked of her ...
(Date:1/20/2017)... ... ... in Suffolk”: a story of love, secrets, and mystery. “Christmas in Suffolk” is ... works in a daycare and looks for inspiration in the local coffee shop as ... Seymour’s new book is an adventure of love and secrets. , After ...
(Date:1/20/2017)... ... January 20, 2017 , ... “God's Miracle Man: Against ... Odds” is the creation of published author, Keith C. A. Tucker, son of Minister ... Fellowship World Outreach pastured by Reverend Mark Hardy , “While sitting up in bed, ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... 5,000 SF expansion and facility enhancement of their 503A compounding pharmacy located in ... the growing demand of physicians and patients throughout the United States for high-quality ...
(Date:1/19/2017)... ... January 19, 2017 , ... WhoHaha , a digital media ... American Heart Association (AHA) to produce a three-part video series that uses humor to ... part of the launch of AHA’s Healthy For Good™ movement, which is designed to ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 The global immunomodulators market ... 2025, according to a new study by Grand ... be predominantly driven by high R&D investments employed ... production of new and therapeutically advanced drugs. This ... at an unprecedented rate into the immunomodulators market ...
(Date:1/19/2017)... Jan. 19, 2017 The Global Therapy Partnering ... access to partnering deals and agreements entered into by ... partnering deals - Top deals by value - Deals ... technology type The report provides understanding and access ... the world,s leading healthcare companies. The report provides ...
(Date:1/19/2017)... 19, 2017 Conference Call and Webcast to Follow ... announced it will release results for the fourth quarter of 2016 ... ... conference call at 4:30 PM ET on Wednesday, February 15, 2017, ... 2016 financial results and other corporate activities. To participate in the ...
Breaking Medicine Technology: