Navigation Links
Insights into cancer earn Premier's Award Commendation
Date:6/4/2008

WEHI's Dr Priscilla Kelly has been honoured with a Commendation in this year's Premier's Award for Medical Research. Dr Kelly is currently a Postdoctoral Fellow and was previously a PhD student in WEHI's Molecular Genetics of Cancer Division. Premier John Brumby presented Priscilla with the Commendation at a ceremony at Government House on 4 June. Dr Kelly's research has focused on two key aspects of cancer biology. First, identifying the genes that enable cells that are becoming cancerous to survive; and second, examining the role of rare stem cells in sustaining the uncontrolled growth of malignant tumours.

The first of her discoveries involves "apoptosis", the biological process by which cells destroy themselves when they are old, damaged or no longer needed. Unfortunately, if this healthy process of cell death is disrupted, the cells that escape self-destruction can instead live on, multiply and form tumours. Dr Kelly discovered that Bcl-x, a protein that inhibits apoptosis, is essential for cancer formation. She unexpectedly found that inactivation of the Bcl-x gene prevented lymphoma development in tumour-prone mice. This finding indicated that cells becoming cancerous use Bcl-x to avoid apoptosis and thereby to extend their lifespan. This discovery has important implications for understanding how cancers develop. It also suggests that prospective new drugs that target Bcl-x could be effective in killing tumour cells.

In other notable work, Dr Kelly showed that in several types of leukaemia the frequency of cells sustaining tumour growth is very high. This discovery runs counter to the widely held belief that tumours are sustained only by a rare sub-population of their cells, called "cancer stem cells." Her finding indicates that effective cancer therapy requires the destruction not only of that rare sub-population but indeed of all the leukaemic cells. This discovery underlines the need to develop cancer therapies that destroy all the cell types within a tumour.

Reflecting on the significance of Dr Kelly's research and her Premier's Award Commendation, the Director of WEHI, Professor Suzanne Cory, said, "We are delighted by the recognition of these intriguing findings by Priscilla Kelly and her WEHI colleagues. Their contributions to understanding how cancers arise and are maintained should eventually help to guide the development of better cancer therapies."


'/>"/>

Contact: Brad Allan
allan@wehi.edu.au
61-393-452-345
Research Australia
Source:Eurekalert

Related medicine news :

1. New insights into common knee injuries
2. SIV infection of natural hosts provides new insights into HIV disease complexity
3. Mothers Blood Could Offer Insights Into Fetal Health
4. Study Offers Insights Into Sensory Perceptions
5. Uncover Key Competitive Intelligence Insights in Webinars Hosted by Best Practices
6. Studies lend insights into colorectal cancer screening
7. Influenza: Insights into cell specificity of human vs. avian viruses
8. Cell Insights Could Bring Better Drugs
9. New insights into inflammation in osteoarthritis
10. Physics provides new insights on cataract formation
11. Cell Insights May Predict Breast Cancers Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... 21, 2017 , ... Hospital M&A activity slowed in the second quarter of ... acquisitions rose to 23 in the second quarter, up 15% from the 20 publicly ... announced deals in the year-ago second quarter. Only four of the transactions disclosed a ...
(Date:7/21/2017)... ... ... The House of Yahweh in Abilene, Texas, has written a new post this week that ... to be more open about positive changes. Yisrayl says the use of force is not ... positive way to solve all; yes, all issues, and he is ready to share this ...
(Date:7/21/2017)... ... ... “Kids aren't born knowing how to regulate their emotions any more than ... St. Louis-based positive education company Generation Mindful. To help with that daunting task, she ... , The kit uses colorful, engaging and educational illustrations and games to teach children ...
(Date:7/21/2017)... ... July 21, 2017 , ... In the ... from the Multicenter Orthopaedics Outcome Network (MOON) demonstrated that patients could perform sports-related ... though activity levels decline over time. The study, presented today at the ...
(Date:7/20/2017)... ... July 20, 2017 , ... TransPixel Volume 2 is a set of ... FCPX timeline. This effect isolates horizontal and vertical lines of pixels and sorts their ... rotating or flipping animation and can be changed using a drop-down menu. Create amazing ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... Lilly and Company (NYSE: LLY ) has entered ... patent litigation in the U.S. District Court for the Eastern ... ® (tadalafil) unit dose patent. This patent was previously ... the agreement, Cialis exclusivity is now expected to end at ... dose patent for Cialis is valid and infringed by companies ...
(Date:7/11/2017)... July 11, 2017  Dr. Echenberg, founder of Echenberg Institute, is announcing ... patients who suffer from painful intercourse and other painful pelvic pain conditions ... due to menopause. ... VuVatech LLC ... Sarasota, Florida -based start-up company, VuVatech LLC, fills a ...
(Date:7/10/2017)... -- The tenth annual BioPharm America™ will take ... the Sheraton Boston Hotel, September 26–27. The event will ... makers and innovative biotech startup companies. The event is ... impactful days. BioPharm America is now part of Biotech ... with 4,500+ life science industry influencers participating in 8+ ...
Breaking Medicine Technology: