Navigation Links
Insights into cancer earn Premier's Award Commendation
Date:6/4/2008

WEHI's Dr Priscilla Kelly has been honoured with a Commendation in this year's Premier's Award for Medical Research. Dr Kelly is currently a Postdoctoral Fellow and was previously a PhD student in WEHI's Molecular Genetics of Cancer Division. Premier John Brumby presented Priscilla with the Commendation at a ceremony at Government House on 4 June. Dr Kelly's research has focused on two key aspects of cancer biology. First, identifying the genes that enable cells that are becoming cancerous to survive; and second, examining the role of rare stem cells in sustaining the uncontrolled growth of malignant tumours.

The first of her discoveries involves "apoptosis", the biological process by which cells destroy themselves when they are old, damaged or no longer needed. Unfortunately, if this healthy process of cell death is disrupted, the cells that escape self-destruction can instead live on, multiply and form tumours. Dr Kelly discovered that Bcl-x, a protein that inhibits apoptosis, is essential for cancer formation. She unexpectedly found that inactivation of the Bcl-x gene prevented lymphoma development in tumour-prone mice. This finding indicated that cells becoming cancerous use Bcl-x to avoid apoptosis and thereby to extend their lifespan. This discovery has important implications for understanding how cancers develop. It also suggests that prospective new drugs that target Bcl-x could be effective in killing tumour cells.

In other notable work, Dr Kelly showed that in several types of leukaemia the frequency of cells sustaining tumour growth is very high. This discovery runs counter to the widely held belief that tumours are sustained only by a rare sub-population of their cells, called "cancer stem cells." Her finding indicates that effective cancer therapy requires the destruction not only of that rare sub-population but indeed of all the leukaemic cells. This discovery underlines the need to develop cancer therapies that destroy all the cell types within a tumour.

Reflecting on the significance of Dr Kelly's research and her Premier's Award Commendation, the Director of WEHI, Professor Suzanne Cory, said, "We are delighted by the recognition of these intriguing findings by Priscilla Kelly and her WEHI colleagues. Their contributions to understanding how cancers arise and are maintained should eventually help to guide the development of better cancer therapies."


'/>"/>

Contact: Brad Allan
allan@wehi.edu.au
61-393-452-345
Research Australia
Source:Eurekalert

Related medicine news :

1. New insights into common knee injuries
2. SIV infection of natural hosts provides new insights into HIV disease complexity
3. Mothers Blood Could Offer Insights Into Fetal Health
4. Study Offers Insights Into Sensory Perceptions
5. Uncover Key Competitive Intelligence Insights in Webinars Hosted by Best Practices
6. Studies lend insights into colorectal cancer screening
7. Influenza: Insights into cell specificity of human vs. avian viruses
8. Cell Insights Could Bring Better Drugs
9. New insights into inflammation in osteoarthritis
10. Physics provides new insights on cataract formation
11. Cell Insights May Predict Breast Cancers Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating ... many ways they remain in the eye of the beholder, according to experts who ... of The American Journal of Managed Care. For the full issue, click here ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
Breaking Medicine Technology: