Navigation Links
Insights into cancer earn Premier's Award Commendation
Date:6/4/2008

WEHI's Dr Priscilla Kelly has been honoured with a Commendation in this year's Premier's Award for Medical Research. Dr Kelly is currently a Postdoctoral Fellow and was previously a PhD student in WEHI's Molecular Genetics of Cancer Division. Premier John Brumby presented Priscilla with the Commendation at a ceremony at Government House on 4 June. Dr Kelly's research has focused on two key aspects of cancer biology. First, identifying the genes that enable cells that are becoming cancerous to survive; and second, examining the role of rare stem cells in sustaining the uncontrolled growth of malignant tumours.

The first of her discoveries involves "apoptosis", the biological process by which cells destroy themselves when they are old, damaged or no longer needed. Unfortunately, if this healthy process of cell death is disrupted, the cells that escape self-destruction can instead live on, multiply and form tumours. Dr Kelly discovered that Bcl-x, a protein that inhibits apoptosis, is essential for cancer formation. She unexpectedly found that inactivation of the Bcl-x gene prevented lymphoma development in tumour-prone mice. This finding indicated that cells becoming cancerous use Bcl-x to avoid apoptosis and thereby to extend their lifespan. This discovery has important implications for understanding how cancers develop. It also suggests that prospective new drugs that target Bcl-x could be effective in killing tumour cells.

In other notable work, Dr Kelly showed that in several types of leukaemia the frequency of cells sustaining tumour growth is very high. This discovery runs counter to the widely held belief that tumours are sustained only by a rare sub-population of their cells, called "cancer stem cells." Her finding indicates that effective cancer therapy requires the destruction not only of that rare sub-population but indeed of all the leukaemic cells. This discovery underlines the need to develop cancer therapies that destroy all the cell types within a tumour.

Reflecting on the significance of Dr Kelly's research and her Premier's Award Commendation, the Director of WEHI, Professor Suzanne Cory, said, "We are delighted by the recognition of these intriguing findings by Priscilla Kelly and her WEHI colleagues. Their contributions to understanding how cancers arise and are maintained should eventually help to guide the development of better cancer therapies."


'/>"/>

Contact: Brad Allan
allan@wehi.edu.au
61-393-452-345
Research Australia
Source:Eurekalert

Related medicine news :

1. New insights into common knee injuries
2. SIV infection of natural hosts provides new insights into HIV disease complexity
3. Mothers Blood Could Offer Insights Into Fetal Health
4. Study Offers Insights Into Sensory Perceptions
5. Uncover Key Competitive Intelligence Insights in Webinars Hosted by Best Practices
6. Studies lend insights into colorectal cancer screening
7. Influenza: Insights into cell specificity of human vs. avian viruses
8. Cell Insights Could Bring Better Drugs
9. New insights into inflammation in osteoarthritis
10. Physics provides new insights on cataract formation
11. Cell Insights May Predict Breast Cancers Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... May 26, 2017 , ... A new analysis of ... the healthiest seniors are located in the Midwest. With the average cost of healthcare ... people are concerned with both the quality and affordability of where they live. An ...
(Date:5/26/2017)... ... ... After raising nearly $30,000 on Kickstarter , about three-times its original ... discounted crowdfunding price on Indiegogo . , “Along with creating an anti-stress gadget ... a fidget toy to the market that was made of superior quality and wouldn’t ...
(Date:5/26/2017)... ... 26, 2017 , ... Dr. Alex Rabinovich, a highly-skilled oral surgeon specializing in ... post on insurance options. If a Bay Area patient has to search for a ... money. Visiting an in-network provider for a second opinion can ensure a patient receives ...
(Date:5/26/2017)... ... May 26, 2017 , ... “Just What Happened in the Garden of Eden”: retells the stories ... Eden” is the creation of published author, Penelope Colt, mother, trader, horse farmer, artist and ... NYC when she was three. At six, they moved to Dayton, Ohio, where Penny ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... Understanind and choosing the most appropriate instruments for research and understanding the basic ... finding. This webinar will focus on innovations in stereo microscopy for brightfield and ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... Enterin Inc., a privately-held CNS pharmaceutical company based in ... Parkinson,s disease (PD), has enrolled the first patient in the ... multicenter study involving patients with PD and taking place at ... 9-to-12-month period. The first stage is open label and involves ... include Denver , Boca Raton ...
(Date:5/10/2017)... , May 10, 2017  The Corporate ... or employees of sleep therapy clinics to call ... sleep therapy clinic is involved in a substantial ... interested in hearing from an employee of a ... in a kickback scheme to provide medical practice groups ...
(Date:5/9/2017)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ... on the development of oral drug delivery systems, ... has granted Oramed a patent titled, "Methods and ... covers Oramed,s invention of an oral glucagon-like peptide-1 ... hormone that stimulates the secretion of insulin from ...
Breaking Medicine Technology: