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Insights gained from growing cold-causing virus on sinus tissue
Date:4/10/2011

nt amounts of two forms of HRV-C, then sequenced the complete virus genome and engineered an identical copy of it in a plasmid vector.

Studying the reproduction of the living, growing virus, he found that HRV-C replication appeared to occur in specific kinds of cells localized in nasal epithelium tissue.

"We also found that HRV-C does not attach to the two receptors that HRV-A and HRV-B use," Bochkov says. "HRV-C uses a distinct, yet unknown, receptor that is absent or under-expressed in many cell lines."

HRV-C also responded differently to antibodies that block receptor binding.

"Antibodies that normally keep HRV-A and HRV-B from binding to their receptors did not prevent HRV-C from binding to them," Bochkov says.

The findings suggest that new approaches are needed to treat HRV-C, says Gern.

"Previous drug candidates for the common cold were tested only against HRV-A and HRV-B," he says. "For more effective medications, we need to also target HRV-C."

Bochkov will continue to use the organ culture system to study details of HRV-C biology.

"It's now clear that these viruses have unique growth requirements," he says.


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Contact: Toni Morrissey
tmorrissey@uwhealth.org
608-263-3223
University of Wisconsin-Madison
Source:Eurekalert

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