Navigation Links
Insights Give New Hope Against Cystic Fibrosis
Date:3/20/2009

Behavior of certain white blood cells may hold key to treatment, scientists say

FRIDAY, March 20 (HealthDay News) -- White blood cells called neutrophils play an important role in the severe lung damage suffered by cystic fibrosis patients, according to U.S. researchers.

Their findings may open up new targets for treatment of CF, which affects about 30,000 people in the United States.

"Cystic fibrosis patients have a problem with turning down the inflammatory response in the lungs. We've found that patients' neutrophils become kind of schizophrenic, doing a number of things that are opposite to the textbook view of neutrophils' role," senior study author Rabindra Tirouvanziam, an instructor in pediatric pulmonary medicine at Stanford University Medical Center and Lucile Packard Children's Hospital, said in a university news release.

It was long believed that neutrophils attacked and destroyed bacteria that became trapped in the excess mucus that collects in the lungs of CF patients. But something goes wrong, and neutrophils quickly die in the lungs, releasing tissue-destroying enzymes as they do.

However, when Tirouvanziam and colleagues analyzed fresh neutrophils from CF patients' sputum, they found that signals from the patients' lung tissue were reprogramming live neutrophils with conflicting messages that "are messing them up completely."

As a result, the neutrophils may release large amounts of an enzyme called human neutrophil elastase, which destroys the elastic fiber of the lungs, the researchers said. In healthy people, neutrophils never release this enzyme into nearby tissue.

The study was published in this week's online issue of the Proceedings of the National Academy of Sciences.

More information

The March of Dimes has more about cystic fibrosis.



-- Robert Preidt



SOURCE: Stanford University, news release, March 16, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Research Released at Annual Society for Adolescent Medicine Meeting Provides Vital Insights into Adolescent Health Issues
2. United Spinal Association Report Reveals the Importance of Studying Multiple Sclerosis in Children: Developing New Insights into MS in Adults
3. Recovery Audit Contractor HealthDataInsights Licenses Milliman Care Guidelines(R)
4. New insights into growth factors role in brain development
5. Gene Insights May Improve Psoriasis Care
6. Researchers Gain Insights Into Aging in Mice
7. Analog Devices Healthcare Team Participates in MIT Forum on Medical Device Industry : ADI's healthcare technology experts Patrick O'Doherty and Tom O'Dwyer offer insights on trends impacting next-generation medical electronic systems.
8. HIV Vaccine Failure Still Brings Insights
9. Genetic Research Offers Insights Into Form of Malaria
10. New insights could lead to a better pneumococcal vaccine
11. Study offers new insights into teenagers and anxiety disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insights Give New Hope Against Cystic Fibrosis
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered ... Latin America . ... ... ... ...
(Date:6/23/2016)... 2016  Experian Health, the healthcare industry ... patient payment and care experience, today announced ... and services that will enhance the breadth ... These award-winning solutions will enable healthcare professionals ... in an ever-changing environment and redefine front-office ...
Breaking Medicine Technology: