Navigation Links
Insights Give New Hope Against Cystic Fibrosis
Date:3/20/2009

Behavior of certain white blood cells may hold key to treatment, scientists say

FRIDAY, March 20 (HealthDay News) -- White blood cells called neutrophils play an important role in the severe lung damage suffered by cystic fibrosis patients, according to U.S. researchers.

Their findings may open up new targets for treatment of CF, which affects about 30,000 people in the United States.

"Cystic fibrosis patients have a problem with turning down the inflammatory response in the lungs. We've found that patients' neutrophils become kind of schizophrenic, doing a number of things that are opposite to the textbook view of neutrophils' role," senior study author Rabindra Tirouvanziam, an instructor in pediatric pulmonary medicine at Stanford University Medical Center and Lucile Packard Children's Hospital, said in a university news release.

It was long believed that neutrophils attacked and destroyed bacteria that became trapped in the excess mucus that collects in the lungs of CF patients. But something goes wrong, and neutrophils quickly die in the lungs, releasing tissue-destroying enzymes as they do.

However, when Tirouvanziam and colleagues analyzed fresh neutrophils from CF patients' sputum, they found that signals from the patients' lung tissue were reprogramming live neutrophils with conflicting messages that "are messing them up completely."

As a result, the neutrophils may release large amounts of an enzyme called human neutrophil elastase, which destroys the elastic fiber of the lungs, the researchers said. In healthy people, neutrophils never release this enzyme into nearby tissue.

The study was published in this week's online issue of the Proceedings of the National Academy of Sciences.

More information

The March of Dimes has more about cystic fibrosis.

<
'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New Research Released at Annual Society for Adolescent Medicine Meeting Provides Vital Insights into Adolescent Health Issues
2. United Spinal Association Report Reveals the Importance of Studying Multiple Sclerosis in Children: Developing New Insights into MS in Adults
3. Recovery Audit Contractor HealthDataInsights Licenses Milliman Care Guidelines(R)
4. New insights into growth factors role in brain development
5. Gene Insights May Improve Psoriasis Care
6. Researchers Gain Insights Into Aging in Mice
7. Analog Devices Healthcare Team Participates in MIT Forum on Medical Device Industry : ADI's healthcare technology experts Patrick O'Doherty and Tom O'Dwyer offer insights on trends impacting next-generation medical electronic systems.
8. HIV Vaccine Failure Still Brings Insights
9. Genetic Research Offers Insights Into Form of Malaria
10. New insights could lead to a better pneumococcal vaccine
11. Study offers new insights into teenagers and anxiety disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insights Give New Hope Against Cystic Fibrosis
(Date:8/22/2014)... CLEVELAND Renal artery stenting to open blockages ... have historically been excluded from modern clinical trials, ... e-published in Catheterization and Cardiovascular Interventions ... Interventions (SCAI). , University Hospitals Case Medical Center,s ... and Professor of Medicine, Case Western Reserve University ...
(Date:8/22/2014)... Centennial, CO (PRWEB) August 22, 2014 ... leading provider of in-home care for seniors, is proud ... Longevity Webinar Series. The upcoming webinar will feature Dr. ... Health at Lenox Hill Hospital in New York City, ... Campaign, and author. The webinar will cover the issues ...
(Date:8/22/2014)... News) -- Many children get anxious or afraid when ... a number of ways that parents can make these ... The first step is to explain to children in ... health, said Rita John, director of the pediatric primary ... Nursing in New York City. "Children need to ...
(Date:8/22/2014)... breakthrough treatments have become available for key subtypes ... these treatments can be pre-identified by looking for ... patients whose lung cancer is driven by rearrangement ... the drug crizotinib, which targets this abnormality. Many ... this success by matching different drugs with specific ...
(Date:8/22/2014)... 2014 For patients who need surgery for facial ... is the least often used, reports a study in ... official journal of the Congress of Neurological Surgeons ... & Wilkins , a part of Wolters Kluwer ... pain relief at much lower cost than other types ...
Breaking Medicine News(10 mins):Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 3Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 2Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 3Health News:Simple Steps Make Shots Less Scary for Kids, Nurse Says 2Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 2Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 3Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 4Health News:More common procedures for painful facial tics carry high costs, reports study in Neurosurgery 2
... DEERFIELD, Ill., Feb. 23 Takeda Pharmaceuticals North America, ... are now available in pharmacies across the U.S. ... was recently approved by the U.S. Food and Drug ... symptomatic non-erosive Gastroesophageal Reflux Disease (GERD), the healing of ...
... Journalist registrations are now being accepted for EULAR, the ... 10th-13th June 2009 in Copenhagen, Denmark. , ... of a valid press card / formal journalist credentials. ... including a working room and an interview room. The ...
... Habits30,000+ Dentists Converge in Chicago February 27-March 1 ... Society (CDS) recently polled more than 300 Chicago-area residents ... choices about dental care and learn more about their ... one of the largest displays of dental products in ...
... The American Association of Clinical Endocrinologists (AACE) and ... been working together to improve the quality of ... thyroid and parathyroid glands. , The quality ... and experience of the physician who performs and/or ...
... The Minnesota Nurses Association,(MNA), as an affiliate of ... of the nation,s largest unions representing registered nurses ... nation. The UAN, the California,Nurses Association/National Nurses ... earlier this week to create the United,American Nurses-National ...
... - First Aid Charity Implements ... Volunteers Quickly and Effectively , ... selected the autonomous,web-based SMS solution from Text Messaging ... its substantial,volunteer base throughout the Sussex region via ...
Cached Medicine News:Health News:KAPIDEX(TM) (dexlansoprazole) delayed release capsules Now Available for the Treatment of GERD 2Health News:KAPIDEX(TM) (dexlansoprazole) delayed release capsules Now Available for the Treatment of GERD 3Health News:Press registration is now open for EULAR 2009, June 10-13, Copenhagen 2Health News:The State of the Tooth: Chicago-Area Residents Talk Dental 2Health News:The State of the Tooth: Chicago-Area Residents Talk Dental 3Health News:AACE/AIUM develop physician certification and accreditation in thyroid/parathyroid ultrasound 2Health News:New National 150,000-Member RN Union Includes Minnesota Nurses Association 2Health News:St John Ambulance Selects Web-Based SMS Solution From Text Messaging Centre (TMC) for Rapid Response Communication via Two-Way SMS Messaging 2Health News:St John Ambulance Selects Web-Based SMS Solution From Text Messaging Centre (TMC) for Rapid Response Communication via Two-Way SMS Messaging 3
(Date:8/21/2014)...  Zacks.com announces the list of stocks featured in the ... the latest news and events impacting stocks and the financial ... HPQ - Free Report ), IBM (NYSE: IBM ... - Free Report ), GlaxoSmithKline plc (NYSE: GSK - ... - Free Report ). Today, Zacks is promoting ...
(Date:8/21/2014)... 2014  ACI Clinical ( www.aciclinical.com ) announces ... Committees. Using this solution, trial sponsors ... standard costs and receive the same expertise that ... services. Leveraging a decade of DMC ... development, statistical programming and meeting facilitation), ACI analyzed ...
(Date:8/21/2014)... Aug. 21, 2014 InfinityQS International, Inc., ... Manufacturing Intelligence , today announces Infusion Chicago, its ... will be held Oct. 9-10, 2014, at the ... to showcase the necessity for implementing a quality ... Manufacturing Intelligence to gain insight into production processes. ...
Breaking Medicine Technology:The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 2The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 4The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 5The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 6The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 7The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 8The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 9The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 10The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 11ACI Clinical: Innovation and Savings in Data Safety Monitoring Committees 2InfinityQS to Host Manufacturing Intelligence Conference in Chicago 2
... software, the latest from Quality Mapping ... application designed specifically for implementing and ... The superior design, functionality, security, and ... for managing a quality program., ,Based ...
... QMS (Quality Management System) is the ... specifically for healthcare labs. The Lab ... meet quality management and accreditation/auditing needs ... more time to devote to better, ...
... The Axioskop 40 FL laboratory ... quality and mechanical stability of research-class ... The microscope is ideal for routine ... and hematology. In addition, it has ...
... Our thawing systems are automated, easy to ... from the outside environment by flexible snap-seal ... bacterial or viral contamination of the water. ... the systems can also accommodate bags of ...
Medicine Products: