Navigation Links
Insights Give New Hope Against Cystic Fibrosis
Date:3/20/2009

Behavior of certain white blood cells may hold key to treatment, scientists say

FRIDAY, March 20 (HealthDay News) -- White blood cells called neutrophils play an important role in the severe lung damage suffered by cystic fibrosis patients, according to U.S. researchers.

Their findings may open up new targets for treatment of CF, which affects about 30,000 people in the United States.

"Cystic fibrosis patients have a problem with turning down the inflammatory response in the lungs. We've found that patients' neutrophils become kind of schizophrenic, doing a number of things that are opposite to the textbook view of neutrophils' role," senior study author Rabindra Tirouvanziam, an instructor in pediatric pulmonary medicine at Stanford University Medical Center and Lucile Packard Children's Hospital, said in a university news release.

It was long believed that neutrophils attacked and destroyed bacteria that became trapped in the excess mucus that collects in the lungs of CF patients. But something goes wrong, and neutrophils quickly die in the lungs, releasing tissue-destroying enzymes as they do.

However, when Tirouvanziam and colleagues analyzed fresh neutrophils from CF patients' sputum, they found that signals from the patients' lung tissue were reprogramming live neutrophils with conflicting messages that "are messing them up completely."

As a result, the neutrophils may release large amounts of an enzyme called human neutrophil elastase, which destroys the elastic fiber of the lungs, the researchers said. In healthy people, neutrophils never release this enzyme into nearby tissue.

The study was published in this week's online issue of the Proceedings of the National Academy of Sciences.

More information

The March of Dimes has more about cystic fibrosis.

<
'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New Research Released at Annual Society for Adolescent Medicine Meeting Provides Vital Insights into Adolescent Health Issues
2. United Spinal Association Report Reveals the Importance of Studying Multiple Sclerosis in Children: Developing New Insights into MS in Adults
3. Recovery Audit Contractor HealthDataInsights Licenses Milliman Care Guidelines(R)
4. New insights into growth factors role in brain development
5. Gene Insights May Improve Psoriasis Care
6. Researchers Gain Insights Into Aging in Mice
7. Analog Devices Healthcare Team Participates in MIT Forum on Medical Device Industry : ADI's healthcare technology experts Patrick O'Doherty and Tom O'Dwyer offer insights on trends impacting next-generation medical electronic systems.
8. HIV Vaccine Failure Still Brings Insights
9. Genetic Research Offers Insights Into Form of Malaria
10. New insights could lead to a better pneumococcal vaccine
11. Study offers new insights into teenagers and anxiety disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insights Give New Hope Against Cystic Fibrosis
(Date:9/22/2014)... 2014 (HealthDay News) -- All sexually active women ... common sexually transmitted infections: chlamydia and gonorrhea, according ... Task Force. The task force noted ... 24 years of age and pregnant women. ... noticeable symptoms. As a result, many infections go ...
(Date:9/22/2014)... New York, New York (PRWEB) September 22, 2014 ... ) filed against Boston Scientific Corp. continue to ... underway in U.S. District Court, Southern District of ... court documents, a new Docket Control Order was ... addresses a number of matters pertaining to the ...
(Date:9/22/2014)... HealthDay Reporter MONDAY, Sept. 22, ... newborn intensive care units (NICU) set up private rooms for ... finds. Researchers at one children,s hospital found that preemies ... when their NICU switched from the traditional "open-bay" layout to ... 22 in the journal Pediatrics , add to evidence ...
(Date:9/22/2014)... Mozes HealthDay Reporter MONDAY, ... American parents are aware of online physician-rating sites, and more ... their children, according to a new national study. The ... -- further suggest that negative online ratings may dissuade parents ... recommended by a neighbor. Conversely, a positive online rating ...
(Date:9/22/2014)... whole eye transplant seems futuristic, if not impossible. ... Department of Defense, researchers at University of California, ... make implantation of an entire, functional eye a ... a holy grail for vision restoration," said Jeffrey ... co-recipient with colleagues at University of Pittsburg Medical ...
Breaking Medicine News(10 mins):Health News:Screen Women for Chlamydia, Gonorrhea, Experts Say 2Health News:Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Order in Federal Boston Scientific Litigation, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Order in Federal Boston Scientific Litigation, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Order in Federal Boston Scientific Litigation, Bernstein Liebhard LLP Reports 4Health News:Newborn ICUs With Private Family Rooms Benefit Preemies: Study 2Health News:Newborn ICUs With Private Family Rooms Benefit Preemies: Study 3Health News:Many Parents Use Online Ratings to Pick a Pediatrician, Study Finds 2Health News:Many Parents Use Online Ratings to Pick a Pediatrician, Study Finds 3Health News:Looking ahead: Whole eye transplant under development 2
... are getting forgetful as you get older, then a research ... School in the South West of England may have good ... such as blueberries, are effective at reversing age-related deficits in ... the science journal Free Radical Biology and Medicine. The ...
... April 10 - Entries for the eighth,annual Michael ... Biomedical Research (FBR) and named after FBR,s chairman, ... to all professional journalists whose reporting,has enhanced public ... the humane and responsible use of animal models., ...
... Systems To Expand ... Network, ... a focus on lower middle-market special situation,and deep value investments, announced today ... for Atlantic Street,Capital with a commitment from funds managed by the investment ...
... to significantly reduce total cost of ... ... Corp.,today announced that Chicago-based uBid, which helps sellers and,manufacturers liquidate excess ... to replace both its Oracle,E-Business Suite enterprise resource planning system and ...
... April 10 HEI, Inc. (Pink Sheets:,HEII; http://www.heii.com ... of fiscal year 2008, which ended March 1, 2008., ... compared to,$9,906,000 for the second quarter of fiscal year ... the second quarter of fiscal year,2008 compared to a ...
... 2008) On Wednesday, April 9, 2008, a symposium ... Experimental Biology was held in which noted scientists discussed ... randomized clinical trials (involving breastfeeding promotion) as well as ... into possible associations between infant feeding and health outcomes ...
Cached Medicine News:Health News:Getting forgetful? Then blueberries may hold the key 2Health News:DeBakey Awards to Recognize Excellence in Biomedical Research Journalism 2Health News:Atlantic Street Capital Announces First Close 2Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 2Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 3Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 4Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 5Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 6Health News:HEI, Inc. Announces Results for the Second Quarter Fiscal 2008 2Health News:HEI, Inc. Announces Results for the Second Quarter Fiscal 2008 3Health News:HEI, Inc. Announces Results for the Second Quarter Fiscal 2008 4Health News:HEI, Inc. Announces Results for the Second Quarter Fiscal 2008 5Health News:New studies add insights to infant feeding and obesity issue 2Health News:New studies add insights to infant feeding and obesity issue 3
(Date:9/22/2014)... 22, 2014 Paragon 28, Inc ... launch of its foot plating system that supplants the ... GORILLA TM R3CON PLATING SYSTEM greatly enhances the ... & Mini-Monster TM Screw Systems and Preserve ... 10 interchangeable subsystems, the GORILLA TM R3CON SYSTEM ...
(Date:9/22/2014)... 22, 2014 The western European automated ... is largely a replacement market with fewer new ... acquisitions and partnerships are redefining competitive landscape in ... service provides details about revenue forecasts, unit shipments, ... across the country. The changing landscape makes it ...
(Date:9/22/2014)... Research ... addition of the  "Global Freeze Drying / ... - Forecast to 2019"  report to their ... global freeze drying market was valued at ... to reach at $2,655.9 million by 2019, ...
Breaking Medicine Technology:Paragon 28, Inc. Launches the GORILLA(TM) R3CON PLATING SYSTEM 2Automated Endoscope Reprocessor Market Trends in Western Europe 2Automated Endoscope Reprocessor Market Trends in Western Europe 3Global Freeze Drying / Lyophilization Equipment (Lab, Pilot, & Industrial) Market - Forecast to 2019 2Global Freeze Drying / Lyophilization Equipment (Lab, Pilot, & Industrial) Market - Forecast to 2019 3
... Our ELISA products for autoimmune testing feature ... as well as specific reflex tests including ... Sm/RNP, SS-A (Ro), SS-B (La), Scl-70 and ... includes a full line of products for ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: