Navigation Links
Insight offers new angle of attack on variety of brain tumors
Date:12/15/2010

A newly published insight into the biology of many kinds of less-aggressive but still lethal brain tumors, or gliomas, opens up a wide array of possibilities for new therapies, according to scientists at Brown University and the University of California, San Francisco (UCSF). In paper published online Dec. 15 in the Journal of the National Cancer Institute, they describe how a genetic mutation leads to an abnormal metabolic process in the tumors that could be targeted by drug makers.

"What this tells you is that there are some forms of tumors with a fundamentally altered process," said Karl Kelsey, a professor of pathology and laboratory medicine and community health in the Warren Alpert Medical School of Brown and one of the paper's senior authors. "This is a really new way to look at potentially modifiable factors in brain tumors."

Scientists have known for a couple of years that a mutation in a gene called IDH is associated with glioma. They've also observed that people with gliomas carrying the mutation survive longer than those afflicted with tumors lacking the mutation. What the Brown and UCSF team show in the new paper is that the mutation is associated with a consistent pattern of an alteration known as "methylation" of the DNA which is associated with changes in gene expression. The pattern of methylation in tumors with the IDH mutation often occurred in metabolic genes, regardless of the tumor's specific type.

Margaret Wrensch, a professor of neurological surgery, epidemiology and biostatistics at UCSF's Helen Diller Family Comprehensive Cancer Center, said what the team found surprising is that DNA from almost all tumors with IDH mutations had the same distinctive methylation pattern. The degree of methylation throughout the genome was unusually high, and the same specific DNA was methylated.

"This one mutation is common to a whole subset of brain tumors," she said. "It's quite unique. It seems to dominate other
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hallmark Insights Completes SAS 70 Type II Audit
2. Employers Voice Opinions on Health Care Plans, Gain Insights on Health Care Reform
3. Happy Feet Clinic Now Open in Buffalo Grove, IL; Starting A Business in Impossible Times: Valuable Insights and Experiences
4. Insightra Medical Inc Gains CE Mark on the Freedom(TM) Inguinal Hernia Product Range
5. Rwandan genocide survivors provide new insights into resilience and PTSD
6. TeraMedica Inks Reseller Agreement With Medical Insight Enterprise Image Viewer Company
7. Carefx Delivers Expert Insights on Health Data Sharing, Collaboration, Quality and Meaningful Use
8. ADD Insights, LLC and The New England ADHD Treatment Center Announce a Joint Seminar Series: Mastering One's ADHD
9. U discovery gives insight into brain replay process
10. Carnegie Mellon research provides insight into brains decision-making process
11. Media Alert: Model N and International Medical Device Leader to Share Insights on Maximizing Sales Performance with Revenue Management
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... Co founders Greenlee and James Chapko, DDS have launched ... immediately deliver fully integrated dental implant services to their patients. ... surgeon. , The Center, whose name is ImplantWide, ... placing dental implants. These 6 roadblocks can discourage any ... placement of dental implants into his or her practice. ...
(Date:5/22/2015)... 22, 2015 Puritan Medical Products, ... the medical, diagnostic, environmental, and forensics industries celebrates ... products in the US. At a time when ... the US, Puritan remains committed to designing and ... Guilford, Maine facility. , Since 1919, Puritan has ...
(Date:5/22/2015)... WI (PRWEB) May 22, 2015 ... honor to be recognized for providing the highest quality ... foundation of health care decision-making,” said Javon R. Bea, ... demonstrates the commitment of our employee/partners to care for ... patients.” , Hospitals do not apply for this award, ...
(Date:5/21/2015)... York, New York (PRWEB) May 21, 2015 ... distributor of patented products, launches the Troll Motor Guide, ... convenient way of boating. , "The recreational boating industry ... Scott J. Cooper, CEO and Creative Director of ... water in record numbers and predicts continued steady growth ...
(Date:5/21/2015)... 2015 Absolute Exhibits, a trade ... state-of-the-art website that is filled with essential exhibiting tools ... information. With its original and inventive design ideas, it ... website shows hundred of pictures of client- owned or ... is not an exhibit rendering site, rather real-time pictures ...
Breaking Medicine News(10 mins):Health News:First of Its Kind Dental Implant Training and Surgicenter to Open in June 2Health News:Maine Swab Company Celebrates 96 Years of American-made Products 2Health News:Mercy Hospital and Trauma Center Receives Women’s Choice Award for Emergency Care - Mercy Health System Javon Bea 2Health News:Great Ways To Celebrate On Memorial Day Weekend- Starting With World Patent Marketing's New Boat Patent 2Health News:Great Ways To Celebrate On Memorial Day Weekend- Starting With World Patent Marketing's New Boat Patent 3Health News:New Convention and City Travel Guides Within the Absolute Exhibits’ Website 2
... infants' exposure to tobacco smoke. Infant exposure to environmental ... syndrome, asthma, and other respiratory conditions. ,A recent study ... of 314 infants living in smoking households. Participating infants ... from the University of Warwick, United Kingdom, found banning ...
... believed to be Britain's first genetically-selected baby after receiving ... baby, named Jamie, was delivered by Caesarean section on ... embryo, to his four-year-old brother Charlie. Charlie has a ... the United States for treatment after being refused permission ...
... Researchers say 85 percent to 90 percent of the people ... fatigue, muscle pain, insomnia and impaired memory. ,It's a difficult ... 1.3 million Americans who suffer from chronic fatigue syndrome, or ... may help them get back a bit of their former ...
... double the risk of an older person developing serious ... independently. Researchers say seniors who do not have anemia, ... cut-off point for the condition's diagnosis, are 1.5-times more ... normal blood hemoglobin levels.// ,Investigators followed 1,146 people, ...
... If you're looking to lower your cholesterol, eating a ... shows a diet that consists of healthy foods, including ... certain drugs. ,Researchers say incorporating almonds into one's diet ... substitutions to try might include a snack of almonds ...
... A new test may be an important tool in ... Clinical Electroencephalography highlights the use of an electrical brain ... to improved treatment. The test, known as an electrophysiological ... the disease.// ,Researchers found 65 percent of patients with ...
Cached Medicine News:
(Date:5/21/2015)... 21, 2015 ... Zwecks Leistungsvergleich zur Expertise und zum ... verwiesen, in denen uneingeschränkt betriebsfähige Systeme, ... ein Aegate-Land: beispielsweise BELGIEN   ... von Arzneimittelfälschungen (FMD) handelt es sich ...
(Date:5/21/2015)... 21, 2015  Today, eight groups representing ... biologics – Alliance for Patient Access, American ... Rheumatology, Biologics Prescribers Collaborative, Clinical Immunology Society, ... and North American Society for Pediatric Gastroenterology, ... to U.S. Food and Drug Administration (FDA) ...
(Date:5/21/2015)... 2015 Bankers Healthcare Group, the leading provider of ... series from medical writer Dr. Pat Bass on ... analyze the decision making process, uncover various preconceived notions that ... how healthcare practitioners can make better, more profitable decisions. ... 7, 2015: " Being More Decisive: You,ve Got To Make ...
Breaking Medicine Technology:EU-Arzneimittel-Richtlinie für gefälschte Medikamente; Aegate-Zusammenfassung als reale Bewertung aus Belgien 2EU-Arzneimittel-Richtlinie für gefälschte Medikamente; Aegate-Zusammenfassung als reale Bewertung aus Belgien 3Physician Groups Urge FDA to Ensure Patient Safety With Greater Transparency in Biosimilar Labeling 2Physician Groups Urge FDA to Ensure Patient Safety With Greater Transparency in Biosimilar Labeling 3Physician Groups Urge FDA to Ensure Patient Safety With Greater Transparency in Biosimilar Labeling 4Medical Writer Dr. Pat Bass Publishes A New Series On The Bankers Healthcare Group BHG360 Blog 2Medical Writer Dr. Pat Bass Publishes A New Series On The Bankers Healthcare Group BHG360 Blog 3
... the easiest test to use on the market. ... no hands-on time. Critical care instructions can be ... the pediatrician's office. Valuable information can be obtained ... Now the focus can be on the results ...
The QuickScreen Pro Multi Drug Screening Test is a rapid, self-timing, qualitative immunoassay for,the detection of drugs of abuse in urine....
... qualitative immunoassays for detecting elevated levels of Luteinizing ... and results are easy to interpret. If ... the control band, then ovulation will probably occur ... test band does not appear or is lighter ...
Detect LH surge for predicting ovulation, Able to detect as low as 40 mIU/mL LH or 30 mIU/mL LH, Simple, easy and accurate, Built-in control system...
Medicine Products: