Navigation Links
Insight offers new angle of attack on variety of brain tumors
Date:12/15/2010

A newly published insight into the biology of many kinds of less-aggressive but still lethal brain tumors, or gliomas, opens up a wide array of possibilities for new therapies, according to scientists at Brown University and the University of California, San Francisco (UCSF). In paper published online Dec. 15 in the Journal of the National Cancer Institute, they describe how a genetic mutation leads to an abnormal metabolic process in the tumors that could be targeted by drug makers.

"What this tells you is that there are some forms of tumors with a fundamentally altered process," said Karl Kelsey, a professor of pathology and laboratory medicine and community health in the Warren Alpert Medical School of Brown and one of the paper's senior authors. "This is a really new way to look at potentially modifiable factors in brain tumors."

Scientists have known for a couple of years that a mutation in a gene called IDH is associated with glioma. They've also observed that people with gliomas carrying the mutation survive longer than those afflicted with tumors lacking the mutation. What the Brown and UCSF team show in the new paper is that the mutation is associated with a consistent pattern of an alteration known as "methylation" of the DNA which is associated with changes in gene expression. The pattern of methylation in tumors with the IDH mutation often occurred in metabolic genes, regardless of the tumor's specific type.

Margaret Wrensch, a professor of neurological surgery, epidemiology and biostatistics at UCSF's Helen Diller Family Comprehensive Cancer Center, said what the team found surprising is that DNA from almost all tumors with IDH mutations had the same distinctive methylation pattern. The degree of methylation throughout the genome was unusually high, and the same specific DNA was methylated.

"This one mutation is common to a whole subset of brain tumors," she said. "It's quite unique. It seems to dominate other
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hallmark Insights Completes SAS 70 Type II Audit
2. Employers Voice Opinions on Health Care Plans, Gain Insights on Health Care Reform
3. Happy Feet Clinic Now Open in Buffalo Grove, IL; Starting A Business in Impossible Times: Valuable Insights and Experiences
4. Insightra Medical Inc Gains CE Mark on the Freedom(TM) Inguinal Hernia Product Range
5. Rwandan genocide survivors provide new insights into resilience and PTSD
6. TeraMedica Inks Reseller Agreement With Medical Insight Enterprise Image Viewer Company
7. Carefx Delivers Expert Insights on Health Data Sharing, Collaboration, Quality and Meaningful Use
8. ADD Insights, LLC and The New England ADHD Treatment Center Announce a Joint Seminar Series: Mastering One's ADHD
9. U discovery gives insight into brain replay process
10. Carnegie Mellon research provides insight into brains decision-making process
11. Media Alert: Model N and International Medical Device Leader to Share Insights on Maximizing Sales Performance with Revenue Management
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... Sept. 16, 2014 (HealthDay News) -- Modern forensic techniques ... injuries might have killed King Richard III, the last ... analysis of the king,s skeletal remains, using whole-body CT ... detailed account of the 11 injuries he suffered at ... Aug. 22, 1485. The modern forensics revealed that ...
(Date:9/16/2014)... Advanced Fertility Center of Texas’ Dr. Michael ... one of the Top Doctors of 2014. The annual ... magazine serving the Houston area. They award esteemed doctors ... outstanding services. This accomplishment will be included in the ... a special publication listing all the winners of the ...
(Date:9/16/2014)... These new programs allow those who haven’t owned a ... $10,000 in a 0% interest free, 2nd down payment assistance ... federal programs, are listed on their private website. The $10,000 ... or move out of the property. The down payment assistance ... no monthly payments paid by the Borrower. The money is ...
(Date:9/16/2014)... Denver, CO (PRWEB) September 16, 2014 ... today that it has been recognized for its high ... published Consulting magazine “The Best Small Firms to Work ... Firms survey annually, with more than 10,000 consultants participating ... Extensive employee satisfaction surveys were conducted, and firms ...
(Date:9/16/2014)... A new clinical trial comparing the ... balloons (DEB) in treating in-stent restenosis (ISR) ... superior late angiographic results and better late ... today at the 26th annual Transcatheter Cardiovascular ... Cardiovascular Research Foundation (CRF), TCT is the ...
Breaking Medicine News(10 mins):Health News:Modern Forensics Provides Clues to Death of Richard III 2Health News:Dr. Michael Allon Receives Esteemed Recognition 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 3Health News:Aspen Advisors Earns Recognition in Consulting Magazine’s "Best Small Firms to Work For" 2Health News:Aspen Advisors Earns Recognition in Consulting Magazine’s "Best Small Firms to Work For" 3Health News:Results of RIBS IV trial reported at TCT 2014 2
... drugs and end up in the ER, CDC says , ... accidental poisonings among American children can be found in the ... year in the United States, more than 71,000 children aged ... overdoses of prescription and over-the-counter drugs, the researchers found. , ...
... , , RANCHO CORDOVA, ... Blindness America announced today the results of their joint nationwide survey ... five 12 to 17-year-olds have difficulty seeing the classroom whiteboard/chalkboard, with ... noted even though nearly half (45 percent) of the children in ...
... , , PALM CITY, Fla., Aug. 4 ... pleased to announce that the Company has formed a partnership ... company. The agreement will enable InstantAmber to offer the ... a valuable information tool that gives parents the ability to ...
... , SADDLE BROOK, N.J., Aug. 4 ... ) is the only hospital in New Jersey and one ... amputees the new PROPRIO FOOT(R), a prosthesis that provides greater ... developed by Ossur, a global leader in orthopedic products, closely ...
... , , , GLENWOOD, Ill., ... recognized leader in personal and environmental radiation monitoring services, today reported financial results ... , Fiscal 2009 Third Quarter Highlights , ... $23.5 million on continued global demand for InLight products and increased domestic badge ...
... Inc. (OTC BB:ALRX.OB - News), an emerging biopharmaceutical company ... of drugs, today announced that the Company has entered ... to establish a drug development center in China Medical ... as a platform for the development of innovative drug ...
Cached Medicine News:Health News:Medicines Top Source of Kids' Poisonings 2Health News:Medicines Top Source of Kids' Poisonings 3Health News:Medicines Top Source of Kids' Poisonings 4Health News:More Than One in Five 12 to 17-Year-Olds Have Trouble Seeing in Class 2Health News:More Than One in Five 12 to 17-Year-Olds Have Trouble Seeing in Class 3Health News:More Than One in Five 12 to 17-Year-Olds Have Trouble Seeing in Class 4Health News:Connectyx Partners with InstantAmber, a Leader in Child Safety and Missing Children Awareness 2Health News:Connectyx Partners with InstantAmber, a Leader in Child Safety and Missing Children Awareness 3Health News:Kessler Institute for Rehabilitation Only Hospital in New Jersey to Offer New Bionic Foot to Amputees 2Health News:Kessler Institute for Rehabilitation Only Hospital in New Jersey to Offer New Bionic Foot to Amputees 3Health News:Landauer, Inc. Reports Fiscal 2009 Third Quarter Results 2Health News:Landauer, Inc. Reports Fiscal 2009 Third Quarter Results 3Health News:Landauer, Inc. Reports Fiscal 2009 Third Quarter Results 4Health News:Landauer, Inc. Reports Fiscal 2009 Third Quarter Results 5Health News:Landauer, Inc. Reports Fiscal 2009 Third Quarter Results 6Health News:Landauer, Inc. Reports Fiscal 2009 Third Quarter Results 7Health News:Landauer, Inc. Reports Fiscal 2009 Third Quarter Results 8Health News:Landauer, Inc. Reports Fiscal 2009 Third Quarter Results 9Health News:AlphaRx and Venturepharm Announce Collaboration Agreement 2
(Date:9/16/2014)... Wash. , Sept. 16, 2014 /PRNewswire/ ... a late stage development company engaged primarily ... medical isotopes for diagnostic and therapeutic applications, ... for technology related to its brachytherapy products.  ... arise from its license from Battelle, under ...
(Date:9/16/2014)... -- Russia,s pharmaceutical ... Pharma 2020 Strategy provides incentives for local producers to ... foreign markets. These trends, however, were affected by recent ... political and economic sanctions imposed on Russia ... Russia responded to the US ...
(Date:9/16/2014)... Sept. 16, 2014 Surgeons at The Children,s ... a case report the first successful use of a ... year-old boy with failing Fontan circulation to bridge him ... 3 years old, the patient received a Fontan circulation ... single ventricle. "The Fontan operation is the final planned ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Licensed Brachytherapy Seed Patent Granted 2Advanced Medical Isotope Corporation Licensed Brachytherapy Seed Patent Granted 3Advanced Medical Isotope Corporation Licensed Brachytherapy Seed Patent Granted 4Global Medicines for Russia 213-Year-Old Boy with Failed Fontan Circulation Bridged to Transplant Using the SynCardia Total Artificial Heart, Published in Annals of Thoracic Surgery 213-Year-Old Boy with Failed Fontan Circulation Bridged to Transplant Using the SynCardia Total Artificial Heart, Published in Annals of Thoracic Surgery 3
... According to new data from,PAREXEL International Corporation (Nasdaq: ... the number of new,industry-sponsored clinical trial initiations, or ... in 2007. PAREXEL,s analysis shows that the,biopharmaceutical industry ... support of new clinical studies for drugs in,2007, ...
... June 20 GlaxoSmithKline,(NYSE: GSK ) today ... has extended the priority review period for PROMACTA(R),(eltrombopag) ... chronic idiopathic thrombocytopenic purpura, as they require more ... Fee action date has,been extended to September 19, ...
Cached Medicine Technology:PAREXEL Data Reveal A Record High Number of Clinical Trials Initiated 2PAREXEL Data Reveal A Record High Number of Clinical Trials Initiated 3PAREXEL Data Reveal A Record High Number of Clinical Trials Initiated 4PAREXEL Data Reveal A Record High Number of Clinical Trials Initiated 5GSK Update on FDA Review of Promacta(R) (Eltrombopag) 2
19 Gauge. Reusable. Block of 4 each....
18 gauge curved. Fine tip. Lightweight design offers precise hemostasis. Pencil design minimizes tissue trauma and induced astigmatism. Knurled handle provides a sure grip and better manipulation....
Set consist of two 23 gauge, stainless steel probes with blunt tips. Probes are 18 cm (7.0 inches) long with 30.5 cm (12 inches) of flexible tubing (O.D. - 0.60 mm, I.D. - 0.30 mm) attached onto the ...
Curved, soft flexible tip allows atraumatic entry through a retinal tear or hole for aspiration of subretinal fluids. 20 gauge x 25 mm cannula attached to 25 gauge x 6 mm tip with 13 mm flexible tubi...
Medicine Products: