Navigation Links
Inside job: new radioactive agents for colon cancer work inside cells

Johns Hopkins scientists have developed a potentially novel way to fight colorectal cancer using tiny molecules to deliver potent barrages of radiation inside cancer cells, unlike current treatments that bind to the surface of cells and attack from the outside and cause unwanted side effects.

In laboratory studies with normal and cancer cells, the new radiation delivery system proved able to specifically target colon cancer cells, and whats left over is likely to be easily filtered out by the kidneys because the delivery systems molecules are so small.

As reported online in PLoS One on October 3, Hopkins colorectal cancer specialists John Abraham, Ph.D., and Stephen Meltzer, M.D. -working with the notion that small molecules generally make better treatment packages-designed small bits of protein only 10 amino acids long as the foundation for their drugs. By contrast, antibodies used to deliver radiation or chemicals can be over one thousand amino acids long.

The team attached radioactive phosphorous, P32, as a test of how well their peptides worked and to our surprise, our first tests showed that cells were ingesting these molecules, thus transferring the radiation inside and killing them by breaking up their DNA and proteins, Abraham says.

While cautioning that the new radiation delivery system is still far from ready for use in people, Abraham notes that P32 gives off high energy that can penetrate through 5 millimeters of human tissue, making it a good candidate to tackle colon cancer since colon cancer cells can often form large, thick tumors into which drugs may not penetrate very well. In addition, P32-labeled peptides may serve another valuable use: to find small metastases or recurrences of colon tumors while they are still small enough to treat. Images of the body can be taken of the labeled peptides as they bind, revealing where stray tumor cells may be nesting.

Abraham, Meltzer and their team then designed and tested a variety of P32-peptides on 18 normal and cancerous human cell samples. The most potent peptide, MA5, could bind to adenocarcinoma cells, which make up 95 percent of all colon cancers, 150 times more strongly than other cell types and be transferred inside cells within 2 hours.


Contact: Nick Zagorski
Johns Hopkins Medical Institutions

Related medicine news :

1. Bacteria Commonly Seen In Radioactive Waste, Hot Springs Found Inside Humans
2. 90 Million Americans Harbor Drug Resistant Bacteria Inside Their Nose
3. Understanding the RNA binding protein and its functions inside the cell
4. Baby Underwent A Heart Surgery Inside The Womb
5. Fimbriae Help Bacteria Stick Around Inside the Body
6. DDT spraying inside houses permitted by WHO
7. Minirobot for Medical Procedures Inside Human Body
8. Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane
9. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
10. Brain Cancer Could be Safely Treated with Radioactive Scorpion Venom
11. Chornobyl Incident Proved Increased Risk of Thyroid Cancer from Radioactive Iodine
Post Your Comments:
(Date:11/30/2015)... , ... December 01, 2015 , ... The Turks & ... one of the leading digital news sites highlighting Caribbean destinations, has published five reasons ... While much of North America shivers under chilly grey skies or worse, it's typically ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... Bi-National Convention of the Federation of Philippine American Chambers of Commerce held from ... Nevada. , 1Heart Caregiver Services, as an active delegate from the Philippine ...
(Date:11/30/2015)... ... 2015 , ... During the National Family Caregivers Month, the ... webinars on topics of ‘Medical and Palliative Care Decisions,’ and ‘Self-Care for Caregivers.’ ... , With a loved one's diagnosis of mesothelioma, the closest family member is ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... . The directory is specialized and only includes chiropractic clinics in the US. ... competent and trustworthy alternative health practitioner when back pain sets in. When people ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... atmosphere for Halloween festivities, the Word of Life Christian Church of Flint, MI, ... and featuring a giant 1.25 ton pile of candy dubbed “Candy Mountain”. , ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 1, 2015 ... of the  "2016 Shigella Testing Market: ... Competitive Strategies, Emerging Opportunities--US, Europe (France, ... to their offering. --> ... of the  "2016 Shigella Testing Market: ...
(Date:11/30/2015)... and BASEL, Switzerland , Dec. 1, ... (Upsher-Smith), through its wholly-owned UK subsidiary Proximagen Ltd., today ... a novel, oral small molecule inhibitor of Vascular Adhesion ... effective in the treatment of inflammatory disease. The VAP-1 ... --> --> Under the ...
(Date:11/30/2015)... 2015 MEDTEC Japon 2016, ... d,Asie portant sur la conception de ... se tiendra à Tokyo ... avril 2016. ... - Logo - ...
Breaking Medicine Technology: