Navigation Links
Inside job: new radioactive agents for colon cancer work inside cells
Date:10/9/2007

Johns Hopkins scientists have developed a potentially novel way to fight colorectal cancer using tiny molecules to deliver potent barrages of radiation inside cancer cells, unlike current treatments that bind to the surface of cells and attack from the outside and cause unwanted side effects.

In laboratory studies with normal and cancer cells, the new radiation delivery system proved able to specifically target colon cancer cells, and whats left over is likely to be easily filtered out by the kidneys because the delivery systems molecules are so small.

As reported online in PLoS One on October 3, Hopkins colorectal cancer specialists John Abraham, Ph.D., and Stephen Meltzer, M.D. -working with the notion that small molecules generally make better treatment packages-designed small bits of protein only 10 amino acids long as the foundation for their drugs. By contrast, antibodies used to deliver radiation or chemicals can be over one thousand amino acids long.

The team attached radioactive phosphorous, P32, as a test of how well their peptides worked and to our surprise, our first tests showed that cells were ingesting these molecules, thus transferring the radiation inside and killing them by breaking up their DNA and proteins, Abraham says.

While cautioning that the new radiation delivery system is still far from ready for use in people, Abraham notes that P32 gives off high energy that can penetrate through 5 millimeters of human tissue, making it a good candidate to tackle colon cancer since colon cancer cells can often form large, thick tumors into which drugs may not penetrate very well. In addition, P32-labeled peptides may serve another valuable use: to find small metastases or recurrences of colon tumors while they are still small enough to treat. Images of the body can be taken of the labeled peptides as they bind, revealing where stray tumor cells may be nesting.

Abraham, Meltzer and their team then de
'/>"/>

Contact: Nick Zagorski
nzagors1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Bacteria Commonly Seen In Radioactive Waste, Hot Springs Found Inside Humans
2. 90 Million Americans Harbor Drug Resistant Bacteria Inside Their Nose
3. Understanding the RNA binding protein and its functions inside the cell
4. Baby Underwent A Heart Surgery Inside The Womb
5. Fimbriae Help Bacteria Stick Around Inside the Body
6. DDT spraying inside houses permitted by WHO
7. Minirobot for Medical Procedures Inside Human Body
8. Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane
9. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
10. Brain Cancer Could be Safely Treated with Radioactive Scorpion Venom
11. Chornobyl Incident Proved Increased Risk of Thyroid Cancer from Radioactive Iodine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... and Leisure Time Physical Activity on Mobility Limitation in ... increases the risk of mobility limitation in old age, ... found in a study which followed up 5,200 public ... at the Gerontology Research Center in Finland and the ... is often repetitive, wears the body and lasts for ...
(Date:4/23/2014)... as Ritalin, may prevent the depletion of self-control, according ... journal of the Association for Psychological Science. , Self-control ... trying to focus attention on a boring textbook are ... explanation for this difficulty: Exerting self-control for a long ... effectively on subsequent tasks. , "It is as if ...
(Date:4/23/2014)... the bottom of Alzheimer,s disease has been a ... controversies. In the latest crook in the research ... the interaction between proteins associated with the disease. ... ACS Chemical Neuroscience , could have important implications ... Krzysztof Nieznanski and colleagues explain that for years, ...
(Date:4/22/2014)... and industry leaders visited the New Jersey Institute ... Joel S. Bloom for the launch of the ... that provides a new model for business innovation ... education assets and investment. U.S. Senator Cory Booker, ... Joe Taylor, New Jersey Lieutenant Governor Kim Guadagno, ...
(Date:4/22/2014)... the last few decades researchers have characterized a set ... and behavior in all types of species, from flies ... identified, but researchers surmise there are more. A team ... of Pennsylvania wondered if big-data approaches could find them. ... by John Hogenesch, PhD, professor of Pharmacology and first ...
Breaking Medicine News(10 mins):Health News:Midlife occupational and leisure-time physical activity limits mobility in old age 2Health News:ADHD drug may help preserve our self-control resources 2Health News:Government and industry leaders herald launch of NJIT's New Jersey Innovation Institute 2Health News:Bioinformatics profiling identifies a new mammalian clock gene 2
... a Million People Nationwide to take 10 Billion, Steps ... WASHINGTON, Sept. 17 More than 1,500 YMCAs ... active living and,healthy eating during "America On the Move ... partnership with the America On the Move,Foundation, aims to ...
... Science Series to Focus on Cardiovascular Disease, Prevention and Treatment Options, ... ... NEW YORK, Sept. 17 The upcoming episode of the "Charlie,Rose ... leading,global killers, which claims almost 900,000 lives each year in the United,States ...
... A new study by researchers at the University of Southern ... , Researchers found that a storyline on the primetime ... and healthy eating habits had a positive impact on the ... study, published in the Sept. 14 Journal of Health Communication ...
... cancer in the head and neck region may have ... without the disease, according to a report in the ... one of the JAMA/Archives journals. , Driving is a ... functions that work together. These functions can be compromised ...
... the Medicare,Quality Improvement Organization for Florida, is ... Laredo, Texas to provide free Diabetes,Empowerment Education ... 33,Florida counties. According to Kathleen Lightbourne, Project ... "The Program is designed to help,people with ...
... Open House - Saturday, October 20,Event to be held ... WEST PLAINS, Mo., Sept. 17 GAMMILL QUILTING ... systems, in,cooperation with it,s nationwide network of dealers, will ... 20. This event is being,held in honor of October,s ...
Cached Medicine News:Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 2Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 3Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 4Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 5Health News:Charlie Rose Science Series Explores Heart Disease 2Health News:Charlie Rose Science Series Explores Heart Disease 3Health News:ER episode impacts viewers' health knowledge and behavior 2Health News:Patients with head and neck cancer may have impairment of some driving skills 2Health News:Medicare Every Diabetic Counts Project Gears Up for Kick-Off 2Health News:'Think Pink with Gammill(R)' 2
(Date:1/15/2014)... , Jan. 15, 2014  Valeant Pharmaceuticals International, Inc. ... that the applicable waiting period under the Hart-Scott-Rodino Antitrust ... previously announced tender offer by its indirect wholly-owned subsidiary, ... shares of common stock of Solta Medical, Inc. (NASDAQ: ...
(Date:1/15/2014)... 15, 2014  Zafgen, Inc., a leading biopharmaceutical company ... obese patients, today announced initial results from its ... of methionine aminopeptidase 2 (MetAP2), in patients with ... obesity.  These results showed improvements in body weight, ...
(Date:1/14/2014)... Jan. 14, 2014  Luminex Corporation (Nasdaq: LMNX ) ... fourth quarter of 2013 on Monday, February 3, 2014. A ... the close of trading. (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ... discuss the operating highlights and financial results for the fourth ...
Breaking Medicine Technology:Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3
... application process, CSA Medical, Inc. ( www.CSAmedical.com ) has ... future plans for its proprietary spray cryotherapy platform on ... will take place from 10:20-10:50 am at the Walter ... CSA Medical is first to harness the power of ...
... EMERYVILLE, Calif., Oct. 7 Onyx Pharmaceuticals, Inc. (Nasdaq: ... teleconference to provide a status update on its New Drug ... webcast of the presentation on our website at: ... 847-585-4405 and using the passcode 28119641. A replay of the ...
Cached Medicine Technology:CSA Medical Selected to Present at AdvaMed 2010: The MedTech Conference 2Onyx Pharmaceuticals Announces Teleconference to Provide Status Update on Carfilzomib 2
... The ACS:180 SE is a ... PLUS, consisting of important physical ... simplify routine operation and increase ... the "Next Generation" ACS:180. The ...
... wide range of Platelet aggregometers allows ... meet particular needs. Single, dual and ... chart recorder outputs or digital computer ... Optical aggregometers, which measure platelet aggregation ...
... you in achieving improved cost efficiency ... to cut costs is constantly increasing. ... eliminate unnecessary manual interactions. Ensuring security ... control mechanisms like pipetting integrity check. ...
... Advia 2400 has minimal ... (as low as 2 ... (40 L/hour) thus maximizing ... universal rack handler facilitates ...
Medicine Products: