Navigation Links
Innovative strategy to facilitate organ repair
Date:4/18/2014

This news release is available in French.

A significant breakthrough could revolutionize surgical practice and regenerative medicine. A team led by Ludwik Leibler from the Laboratoire Matire Molle et Chimie (CNRS/ESPCI Paris Tech) and Didier Letourneur from the Laboratoire Recherche Vasculaire Translationnelle (INSERM/Universits Paris Diderot and Paris 13), has just demonstrated that the principle of adhesion by aqueous solutions of nanoparticles can be used in vivo to repair soft-tissue organs and tissues. This easy-to-use gluing method has been tested on rats. When applied to skin, it closes deep wounds in a few seconds and provides aesthetic, high quality healing. It has also been shown to successfully repair organs that are difficult to suture, such as the liver. Finally, this solution has made it possible to attach a medical device to a beating heart, demonstrating the method's potential for delivering drugs and strengthening tissues. This work has just been published on the website of the journal Angewandte Chemie.

In an issue of Nature published in December last year, a team led by Ludwik Leibler presented a novel concept for gluing gels and biological tissues using nanoparticles . The principle is simple: nanoparticles contained in a solution spread out on surfaces to be glued bind to the gel's (or tissue's) molecular network. This phenomenon is called adsorption. At the same time the gel (or tissue) binds the particles together. Accordingly, myriad connections form between the two surfaces. This adhesion process, which involves no chemical reaction, only takes a few seconds. In their latest, newly published study, the researchers used experiments performed on rats to show that this method, applied in vivo, has the potential to revolutionize clinical practice.

In a first experiment, the researchers compared two methods for skin closure in a deep wound: traditional sutures, and the application of the aqueous nanoparticle solution with a brush. The latter is easy to use and closes skin rapidly until it heals completely, without inflammation or necrosis. The resulting scar is almost invisible.

In a second experiment, still on rats, the researchers applied this solution to soft-tissue organs such as the liver, lungs or spleen that are difficult to suture because they tear when the needle passes through them. At present, no glue is sufficiently strong as well as harmless for the organism. Confronted with a deep gash in the liver with severe bleeding, the researchers closed the wound by spreading the aqueous nanoparticle solution and pressing the two edges of the wound together. The bleeding stopped. To repair a sectioned liver lobe, the researchers also used nanoparticles: they glued a film coated with nanoparticles onto the wound, and stopped the bleeding. In both situations, organ function was unaffected and the animals survived.

"Gluing a film to stop leakage" is only one example of the possibilities opened up by adhesion brought by nanoparticles. In an entirely different field, the researchers have succeeded in using nanoparticles to attach a biodegradable membrane used for cardiac cell therapy, and to achieve this despite the substantial mechanical constraints due to its beating. They thus showed that it would be possible to attach various medical devices to organs and tissues for therapeutic, repair or mechanical strengthening purposes.

This adhesion method is exceptional because of its potential spectrum of clinical applications. It is simple, easy to use and the nanoparticles employed (silica, iron oxides) can be metabolized by the organism. It can easily be integrated into ongoing research on healing and tissue regeneration and contribute to the development of regenerative medicine.


'/>"/>

Contact: Didier Letourneur
didier.letourneur@inserm.fr
33-014-025-8600
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert  

Related medicine news :

1. New grants for innovative Alzheimers disease research announced by AHAF
2. NIH awards $7.8 million for innovative HIV vaccine approaches
3. Advances in ataxia research to be featured at USFs Innovative Learning and Simulation Center
4. Saving brains in developing countries: $11.8 million for innovative ideas worldwide
5. Teleconcussion--A new, innovative strategy for assessing young athletes
6. Collegiate inventors honored for innovative science and technology advances
7. Innovative sobriety project reduces DUI and domestic violence arrests, study finds
8. Ward Management Group Wins Innovative Marketing Campaign Award
9. InnoVative Capital Closes $41 Million FHA 242 Refinancing, Cutting Morehead Memorial Hospital's Loan Rate by 21% and Reducing Debt Service by $5 Million
10. Physician Director of ICU Honored for Innovative Telemedicine Program at Healdsburg District Hospital
11. AGNITY Healthcare Teams with Alcatel-Lucent to Deliver Innovative Mobile Healthcare Solutions over 4G LTE Mobile Networks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Innovative strategy to facilitate organ repair
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... Every year, ... invigorating and educational conference, InstructureCon. Each annual event is coupled with a dynamic theme ... with a James Bond theme, Mission: InstructureCon 0017. , To extend their partnership ...
(Date:7/24/2017)... ... ... although people are taking more steps to protect themselves from sunburn, half of all adults ... within the past year. It’s common and people have been dealing with them since the ... become conscientious of the risks that accompany sunburns. , The team at AloeVera.com , ...
(Date:7/24/2017)... ... July 24, 2017 , ... Sharon Kleyne, host of the ... Health on VoiceAmerica sponsored by Nature’s Tears® EyeMist® recently talked on the air about ... in China. , The article by Zidor Aldama described the situation in which Chinese ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... the prestigious StorErotica “Consumer’s Choice” Award, for favorite sex toy. Created in collaboration ... annual StorErotica Awards to be consumer voted. The Magic Wand Rechargeable won in ...
(Date:7/24/2017)... Church, VA (PRWEB) , ... July 24, 2017 ... ... figuring out how to change manufacturers future. , The agency is hammering out ... Cures Act, one of the farthest-ranging laws ever to affect FDA-regulated firms. The ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... , July 10, 2017  US medical equipment and ... 2021, according to Medical Equipment & Supplies: ... Freedonia Focus Reports. Continued increases in demand for medical ... of the population and supported by gains in disposable ... and supplies. New product introductions will also drive sales ...
(Date:7/6/2017)... division of Diplomat Specialty Infusion Group, is celebrating a decade of empowering ... celebrate its anniversary, ThriveRx recently launched a redesigned website at thriverx.diplomat.is ... to create the best user experience for consumers and health care professionals. ... Diplomat Pharmacy ... "We,ve made several great strides throughout the past 10 years," ...
(Date:7/1/2017)... June 30, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... earnings conference call will be broadcast live over the Internet ... A news release detailing the quarterly results will be made ... conference call. The live audio webcast can be ... . It will be archived for replay following the conference ...
Breaking Medicine Technology: