Navigation Links
Innovative screening method identifies possible new treatment for fatal childhood disease
Date:4/18/2011

esterification is the formation of esters, fatty compounds derived from acids). The discovery of a new use for a drug already on the market is always good news, as the drug has already been tested for safety.

Sturley and his team took advantage of the fact that the gene responsible for 95% of NP-C cases has been present throughout evolution, including in the evolutionarily distant yeast. They used what is called a "synthetic lethality screen" on a yeast model of NC-P. Synthetic lethality occurs when the combination of otherwise insignificant mutations in two or more genes leads to cell death. In other words, they determined which combination of mutations was lethal to the yeast.

The cell nucleus contains proteins called histones. During histone acetylation, a group of atoms called an acetyl group is substituted for a hydrogen atom, and during histone deacetylation, it is removed. When deletion of genes responsible for histone acetylation in the yeast model led to an accumulation of lipids, the researchers hypothesized that an imbalance in histone acetylation caused NP-C disease.

They found that the majority of the 11 histone deacetylase (HDAC) genes were impaired. They then discovered that the cancer drug, an HDAC inhibitor, repaired the genes. Sturley and his team concluded that the genetic pathways that exacerbate lethality in the yeast model could be reversed in human cells, providing a novel treatment for NP-C. In short, using their "exacerbate-reverse" approach, they identified the pathways that exacerbate lethality in their yeast model and then used drugs to manipulate those pathways in the opposite direction.

The next step is to test this new use of the cancer drug on mice and, eventually, hopes Sturley, in clinical trials. Although scientific curiosity originally led Sturley to study NP-C, he is now motivated by the search for a cure. "Once you get to know some of these kids and their families," he says, "it can't be othe
'/>"/>

Contact: Ann Rae Jonas
arj2116@columbia.edu
212-305-3900
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UNC Lineberger scientist receives Innovative Research Grant from Stand Up to Cancer
2. Research team honored for innovative science to advance cancer research
3. Innovative technique gives vision researchers insight into how people recognize faces
4. University Hospitals Case Medical Center testing innovative heat therapy for premature ejaculation
5. Innovative International Healthcare Partnership established at Arizona State University
6. Innovative virtual reality exposure therapy shows promise for returning troops
7. 3rd international conference on innovative approaches in head and neck oncology
8. Cancer prevention expert honored for innovative tobacco research
9. Elsevier launches innovative online radiology board review product
10. UC Davis surgeons test innovative device in patient with swallowing disorder
11. Experts say direct-to-consumer genetic tests need innovative oversight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... New York, NY (PRWEB) July 26, 2014 ... by Infosecurity magazine on July 23rd, new research by ... are starting to rewrite their playbook, now focusing more ... individuals en masse who have become increasingly wise to ... (GDF) founder and CEO/CTO, Joe Caruso, talks about ...
(Date:7/26/2014)... “Healthy teeth are important, and having your teeth cleaned regularly ... Health Center of Snohomish County (CHC) in their article, “ ... integration of medical and dental care is the best way ... encourage regular cleanings and checkups not only with a family ... adults will find knowledgeable and friendly staff that ...
(Date:7/26/2014)... 26, 2014 Multiple sclerosis (MS), ... is an inflammatory disease in which the insulating ... spinal cord are damaged. This damage disrupts the ... communicate, resulting in a wide range of signs ... problems. Multiple sclerosis takes several forms, with new ...
(Date:7/26/2014)... 26, 2014 The U.S. Food & Drug ... includes a new medication guide for AndroGel to include blood ... of taking the topical low testosterone medication, notes Wright & ... the makers of the low testosterone theapy drug, has also ... swelling or redness as signs of a blood clot in ...
(Date:7/26/2014)... Kentucky (PRWEB) July 26, 2014 ... on the playing field; however, concussions in ... injuries. The occupations with the highest risk of ... ,     Firefighters ,     Police officers , ... workers ,     Delivery personnel , ...
Breaking Medicine News(10 mins):Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 2Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 3Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 4Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 5Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 6Health News:Common Dental Care Questions Answered by Community Health Center of Snohomish County in Recent Article 2Health News:Multiple Sclerosis Therapeutics Clinical Trials Market Review H2 2014 Analysis Report Available at MarketOptimizer.org 2Health News:Multiple Sclerosis Therapeutics Clinical Trials Market Review H2 2014 Analysis Report Available at MarketOptimizer.org 3Health News:Multiple Sclerosis Therapeutics Clinical Trials Market Review H2 2014 Analysis Report Available at MarketOptimizer.org 4Health News:FDA Updates AndroGel Risks to Include Blood Clots In Legs and Lungs as Testosterone Treatment Lawsuits Move Forward 2Health News:FDA Updates AndroGel Risks to Include Blood Clots In Legs and Lungs as Testosterone Treatment Lawsuits Move Forward 3Health News:FDA Updates AndroGel Risks to Include Blood Clots In Legs and Lungs as Testosterone Treatment Lawsuits Move Forward 4Health News:FDA Updates AndroGel Risks to Include Blood Clots In Legs and Lungs as Testosterone Treatment Lawsuits Move Forward 5Health News:KORT Physical Therapists Take the Mystery Out of Identifying and Treating Workplace Head Injuries 2Health News:KORT Physical Therapists Take the Mystery Out of Identifying and Treating Workplace Head Injuries 3
... May 6 (HealthDay News) -- Nearly one in seven nursing ... each year, new research shows. Infections are a leading ... nearly 400,000 lives annually. Before receiving reimbursement from Medicare ... do not are issued deficiency citations. A new study ...
... , FRIDAY, May 6 (HealthDay News) -- Nail salon workers ... chemicals, a new study warns. Researchers recruited 80 Vietnamese ... measured their work-related exposure to toluene, ethyl acetate and isopropyl ... American Journal of Public Health , showed that the workers ...
... Rhythm Society and the European Heart Rhythm Association issued ... cardiovascular genetic testing at the Heart Rhythm Society,s 32nd ... PhD, a leader in the field of inherited cardiovascular ... NYU Langone Medical Center, was co-lead author of the ...
... FRIDAY, May 6 (HealthDay News) -- Americans walked and biked ... earlier, new research finds. But the increases were minor, ... 5 in the American Journal of Public Health . ... and 2009 U.S. National Household Travel Surveys and found that ...
... receive the 2011 ESCMID Award for Excellence on Clinical Microbiology ... and Infectious Diseases (ESCMID). He has been awarded the prize ... vaccines and vaccinology. The award of 10,000 will be ... ICC meeting in Milan, Italy, which takes place from 7 ...
... Center has received a $500,000 grant from the California Community ... Kids and Their Families program. Over a two-year period, ... services by COACH for Kids to vulnerable children in underserved ... neighborhoods of Watts and Compton. "Promoting ...
Cached Medicine News:Health News:1 in 7 U.S. Nursing Homes Cited for Poor Infection Control 2Health News:New guidelines for cardiovascular genetic testing 2Health News:Americans Walking, Biking a Bit More, Research Shows 2Health News:Cedars-Sinai's mobile medical clinics receive $500,000 grant from California Community Foundation 2
(Date:7/25/2014)... Research and Markets has announced the addition ... report to their offering. ... An ophthalmic diagnostic device is a ... in the human visual pathway. Ophthalmic devices are used ... glaucoma, retinal disorders, conjunctivitis, and dry eyes. ...
(Date:7/25/2014)... July 25, 2014  Semler Scientific, Inc. (Nasdaq: ... risk assessment company that develops patented products that ... chronic diseases, today reported financial results for the ... 2014. "The second quarter of ... Doug Murphy-Chutorian , M.D., chief executive officer ...
(Date:7/25/2014)... , July 25, 2014  Arena Pharmaceuticals, Inc. (NASDAQ: ... a corporate update and report second quarter 2014 financial ... Friday, August 1, 2014. That same day, Arena will ... Eastern Time (5:30 a.m. Pacific Time). ... for domestic callers and 914.495.8552 for international callers. Please ...
Breaking Medicine Technology:Global Ophthalmic Diagnostic Devices Market 2014-2018: Key Vendors are Alcon, Carl Zeiss, Haag-Streit and Topcon 2Semler Reports Second Quarter 2014 Financial Results 2Semler Reports Second Quarter 2014 Financial Results 3Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 3
... 28, 2011 The Oklahoma Bureau of Narcotics (OBN) ... WBH, the owner/operator of the Energy-from-Waste facility in Tulsa ... state.  Since March 1, 2011, through the Safe Trip ... permanent drug disposal metal containers in police and sheriff ...
... July 28, 2011 Futbol Club (FC) Barcelona, ... Gates Foundation kicked off a three-year partnership today to ... attention to the promise of life-saving vaccines.  Bill Gates, ... with FC Barcelona President Sandro Rosell and Manager Josep ...
Cached Medicine Technology:Narcotics Bureau Partners With Covanta Energy and the City of Tulsa for Safe Prescription Drug Disposal 2Narcotics Bureau Partners With Covanta Energy and the City of Tulsa for Safe Prescription Drug Disposal 3Futbol Club Barcelona and the Bill & Melinda Gates Foundation Team Up to End Polio and Give Every Child an Equal Shot at Life 2Futbol Club Barcelona and the Bill & Melinda Gates Foundation Team Up to End Polio and Give Every Child an Equal Shot at Life 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: