Navigation Links
Innovative algorithm spots interactions lethal to cancer
Date:9/3/2014

ey have demonstrated for the first time that such a network can be used to successfully predict the response of cancer cells to various treatments and predict a patient's prognosis based on personal genomic information.

"We started this research from a very simple observation: If two genes are synthetically lethal, they are highly unlikely to be inactive together in the same cell," said Dr. Ruppin. "As cancer cells undergo genetic alterations that result in gene inactivation, we were able to identify synthetic lethal interactions by analyzing large sets of cancer genetic profiles. Genes that were found to be inactive in some cancer samples, but were almost never found to be inactive together in the same sample, were identified as synthetically lethal."

The crux of the study, according to Ms. Jerby-Arnon, is the synergy between the computational research and the ensuing experiments, conducted at the Beatson Institute and the Broad Institute, to verify the predictive power of the new algorithm.

A road to new therapies

In addition to their promising role in tailoring personalized cancer treatment, the synthetic lethal pairs discovered may also be used to repurpose drugs, which are currently used to treat other non-cancer disorders, to target specific cancer types. "We applied our pipeline to search for drugs that may be used to treat certain forms of renal cancer. We identified two such drugs, currently used to treat hypertension and cardiac dysrhythmia, that may be quite effective," said Dr. Ruppin. "Experiments in cell lines performed by the Gottlieb lab at the Beatson Institute support these findings, and we are now working on additional validations in mice."

The researchers are hopeful that their study will help boost the experimental detection of synthetic lethality in cancer cells and offer further insight into the unique susceptibilities of these pathological cells. "In this study, we have demonstrated the clinical ut
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New grants for innovative Alzheimers disease research announced by AHAF
2. NIH awards $7.8 million for innovative HIV vaccine approaches
3. Advances in ataxia research to be featured at USFs Innovative Learning and Simulation Center
4. Saving brains in developing countries: $11.8 million for innovative ideas worldwide
5. Teleconcussion--A new, innovative strategy for assessing young athletes
6. Collegiate inventors honored for innovative science and technology advances
7. Innovative sobriety project reduces DUI and domestic violence arrests, study finds
8. Ward Management Group Wins Innovative Marketing Campaign Award
9. InnoVative Capital Closes $41 Million FHA 242 Refinancing, Cutting Morehead Memorial Hospital's Loan Rate by 21% and Reducing Debt Service by $5 Million
10. Physician Director of ICU Honored for Innovative Telemedicine Program at Healdsburg District Hospital
11. AGNITY Healthcare Teams with Alcatel-Lucent to Deliver Innovative Mobile Healthcare Solutions over 4G LTE Mobile Networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... Anitha Nallari, MD has joined Shakir ... in Columbus, OH. Dr. Nallari will see patients with ... breast cancer, lung cancer, GI and gallbladder cancer, head and ... hematology. , Dr. Anitha Nallari is Board Certified ... Board of Internal Medicine. She completed her medical education in ...
(Date:5/6/2015)... (PRWEB) May 06, 2015 Follow ... sanitizers are increasing, driven by the rising consumer awareness ... spread of contagious diseases. Hand washing is becoming a ... consumer apprehension over contracting infections. Periodic outbreak of Avian ... recent Ebola virus disease (EVD) epidemic in ...
(Date:5/6/2015)... has opened press registration for TU-Automotive Detroit as the ... headlines of major publications world-wide. With 150+ speakers from ... to share their visions for the future of connected ... to go behind the scenes and hear major automakers’ ... year we’re releasing a preview of all the major ...
(Date:5/6/2015)... 2015 Dr. Vito C. Quatela, one of ... recently completed a medical mission trip to Hanoi, Vietnam with ... affected by microtia and other deformities of the face. , ... ended on April 26, Dr. Quatela and his team performed ... congenital deformity where the outside of the ear is underdeveloped. ...
(Date:5/6/2015)... The Florida Council on Compulsive Gambling, Inc. (FCCG), along ... Geriatric Education Center, Mental Health Association of Southeast Florida, ... Abuse, will hold its annual conference in Ft Lauderdale ... , This important event will address topics such as ... clinical training for problem gambling treatment services. “This ...
Breaking Medicine News(10 mins):Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 2Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 3Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 2Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 3Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 4Health News:Press Registration for TU-Automotive Detroit Now Open 2Health News:Dr. Vito Quatela Completes Successful 10-Day Medical Mission Trip to Hanoi, Vietnam 2Health News:Dr. Vito Quatela Completes Successful 10-Day Medical Mission Trip to Hanoi, Vietnam 3Health News:Conference on Problem Gambling to be held in Ft. Lauderdale, FL 2
... services company, explains the repercussions and risks of waiting to file for ... ... make the mistake of waiting too long to apply for Social Security ... of people in the Social Security Disability Insurance (SSDI) process ...
... SEIU announced today that,its California healthcare members have voted ... state,s long-term care workers. The International,Executive Board (IEB), ... of the non-binding advisory vote next month as it,considers ... workers. , "This ...
... of Eastern,Pennsylvania has begun overseeing and coordinating services ... of services to,Medicare beneficiaries. These services include ... providing,transportation to and from those appointments and providing ... Bravo Health. , ...
... statement from Peter H. Cressy, president of the Distilled Spirits ... The Distilled Spirits Council is pleased to see ... point out that these declines may reflect the greater decline ... drinking age. The research is clear that most youth who ...
... ... Boulder Creek, CA (PRWEB) December 11, 2008 -- Two ... taking care of their employees and have been rewarded for that ... has earned each the ,HeartMath Hospital, designation and the ,Continuity of ...
... for some creative stocking-,stuffer ideas to keep your family,s teeth clean and healthy ... Ohio and Indiana recommends the following gift,ideas to ensure healthy teeth and gums ... Toothbrushes, Musical toothbrushes play popular songs ... minutes. A musical toothbrush is a great way to make, ...
Cached Medicine News:Health News:Time is Money When People Wait Too Long to Apply for Social Security Disability Benefits 2Health News:Time is Money When People Wait Too Long to Apply for Social Security Disability Benefits 3Health News:Time is Money When People Wait Too Long to Apply for Social Security Disability Benefits 4Health News:California SEIU Members Support Single Union Uniting Long-Term Care Workers 2Health News:California SEIU Members Support Single Union Uniting Long-Term Care Workers 3Health News:Patient Care Means Employee Care at Illinois Hospitals 2Health News:Patient Care Means Employee Care at Illinois Hospitals 3Health News:Patient Care Means Employee Care at Illinois Hospitals 4Health News:Patient Care Means Employee Care at Illinois Hospitals 5Health News:Patient Care Means Employee Care at Illinois Hospitals 6
(Date:5/6/2015)... , May 05, 2015 Research and ... the addition of the "Chromatography (Instruments and ... report to their offering. Chromatography is ... identifying the component of a complex mixture by ... the decades the scientists have considered chromatography as ...
(Date:5/6/2015)... May 06, 2015 Research and Markets ... of the "Global Insulin Patch Market Opportunity ... Highly advanced technology like ultrasound and iontophoresis are ... patches. Depending upon the type of technique, their ... reach of several patients. In long-term, it would ...
(Date:5/6/2015)... , UAE, May 6, 2015 NVSSoft, ... solutions, has been named a "Cool Vendor" by top IT ... Emerging Markets 2015". Gartner defines a "Cool Vendor" ... innovative, impactful and intriguing. The report highlights that, ... organizations operate in emerging markets should look at local technologies ...
Breaking Medicine Technology:Global Chromatography (Instruments and Reagents) Market 2015 - Forecasts to 2019 2Global Insulin Patch Market Opportunity Analysis 2015 2UAE-Based Software Developer Named by Gartner as a Cool Vendor 2UAE-Based Software Developer Named by Gartner as a Cool Vendor 3UAE-Based Software Developer Named by Gartner as a Cool Vendor 4
... Stimulator is a portable, battery-powered bone growth stimulator ... The device is worn for 30 minutes each ... the fusion site. The device uses a unique ... low energy signal that is very potent in ...
... The Frontier device is ... device with one atrial and ... with chronic atrial fibrillation (AF) ... node ablation and who have ...
... incorporates new advances in CRT and ICD therapy. ... Platform. With this device, we offer: ... or less throughout the life of the device ... longevity over InSync II Marquis) , Separately programmable ...
Intrinsic Dual Chamber ICD With MVP Mode (Managed Ventricular Pacing). MVP promotes intrinsic conduction and is clinically proven to reduce unnecessary right ventricular (RV) pacing to approximately...
Medicine Products: