Navigation Links
'Innocent bystanders' can be the cause of tumor development
Date:3/3/2008

Tumor growth has commonly been viewed as a result of mutations in a given cell that will therefore proliferate uncontrollably. However, a study conducted at the University of Helsinki, Finland, has demonstrated that in certain type of gastrointestinal polyps, the cause of tumor development are mutations in the smooth muscle cells, previously regarded as innocent bystanders. The results emphasize the importance of interactions between tissue types, and open up possibilities to develop new treatment strategies targeting the intercellular signaling.

Gastrointestinal polyps are tumors that can both block the digestion and progress to cancer. The cell-type making up the bulk of the polyps and therefore responsible for the adverse effects are the hyper proliferating epithelial cells, which normally line the inner surface of the gastrointestinal tract. Therefore studies addressing the possible mechanisms of polyp development have traditionally focused on epithelial cells. However, the results from professor Tomi Mkels research group demonstrate that origin of at least certain polyps is found elsewhere than in the pathologically growing epithelium. By restricting the mutations in mice to the smooth muscle cells that encircle the epithelium, researcher Pekka Katajisto discovered that deletion of the tumor suppressor gene Lkb1 leads to excessive proliferation of neighboring epithelial cells and tumor development.

The results demonstrate that Lkb1 deletion in smooth muscle cells disturbes the signaling between cells. Normally the smooth muscle cells appear to hold-back the proliferation of their neighboring epithelial cells by signals mediated by the growth factor TGF, but this signaling is reduced in the studied tumors. As a consequence, the epithelium undergoes accelerated proliferation. The same intercellular signaling defect was also noted in the Peutz-Jeghers polyposis caused by hereditary LKB1 mutations.


'/>"/>

Contact: Pekka Katajisto
pekka.katajisto@helsinki.fi
358-407-085-349
University of Helsinki
Source:Eurekalert

Page: 1

Related medicine news :

1. Photo: Introducing a New Line of Baby and Toddler Shirts that Can Help Protect Innocent Babies During Flu Season
2. Government Concludes Vaccines Caused Autism
3. Tysabri May Cause Liver Damage, Health Officials Say
4. Cause of effectiveness discovered for a cirrhosis treatment useful in 40 percent of patients
5. NIH awards OHSU researcher $1.2 million to determine causes of, risk factors for pelvic floor injury
6. Taking Multiple Pain Relievers May Cause Complications
7. Biannual Antibiotics May Cut Major Cause of Blindness in Africa
8. Dr. Welsh Self-Test Diagnoses Glaucoma, the Leading Cause of Preventable- Blindness
9. Hypnosis helped Stanford/Packard physicians pinpoint cause of childrens seizures
10. Yale study offers insight into possible cause of lymphoma
11. Scientists Show Stem Cells Dont Cause Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... ... LLC, announced the first national #QuackGivesBack campaign which supported local breast cancer ... our first franchise-wide Quack Gives Back initiative, and we’re very pleased ...
(Date:12/8/2016)... ... December 08, 2016 , ... CURE Media Group, the nation’s leading ... has aligned with Upstage Lung Cancer in efforts to combat lung cancer, announced CURE ... Hennessy, Jr said, “CURE Media Group is honored to team up with Upstage Lung ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... modes of access for customers and employees that are both engaging and easy ... with Service Smart Technology, the software company revealed today its plans to roll ...
(Date:12/8/2016)... ... December 08, 2016 , ... STAT courier is pleased ... a convenient service for Texas, they are expanding their presence in Dallas. One of ... spree that will bring new jobs to the Dallas and Forth Worth market. STAT ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... Vida ... raised an $18M Series B led by Canvas Ventures . Other investors include ... to scale its mobile platform to serve more consumers who are managing chronic ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... , Dec 9, 2016 Research and ... Market 2016-2020" report to their offering. ... The global travel vaccines market to ... The report covers the present scenario and the growth prospects ... market size, the report considers the revenue generated from the sales ...
(Date:12/8/2016)... Calif. , Dec. 8, 2016 IRIDEX Corporation ... to offer newly issued shares of common stock, $0.01 par ... to an underwritten public offering.  The final terms of the ... time of pricing, and there can be no assurance as ... IRIDEX expects to use the net proceeds it will ...
(Date:12/8/2016)... LONDON , Dec. 8, 2016  The global ... of 8.8% during the forecast period of 2016 to ... billion by 2021 from USD 18.21 billion in 2016. ... surgeries, rising incidences of sports related injuries and spinal ... and rising need of effective blood loss management. ...
Breaking Medicine Technology: