Navigation Links
Inner workings of molecular thermostat point to pathways to fight diabetes, obesity
Date:9/11/2009

PHILADELPHIA Best known as the oxygen-carrying component of hemoglobin, the protein that makes blood red, heme also plays a role in chemical detoxification and energy metabolism within the cell. Heme levels are tightly maintained, and with good reason: Too little heme prevents cell growth and division; excessive amounts of heme are toxic.

Researchers at the University of Pennsylvania School of Medicine have discovered a molecular circuit involving heme that helps maintain proper metabolism in the body, providing new insights into metabolic disorders such as obesity and diabetes.

The work builds on 2007 findings from the same team, led by Mitchell Lazar, MD, PhD, Director of Penn's Institute for Diabetes, Obesity, and Metabolism, showing that a protein called Rev-erbα coordinates the daily cycles of heme. The new research, published online in Genes & Development, makes it clear that Rev-erbα, by controlling the production of heme, also plays a key role in maintaining the body's correct metabolism. This happens through a molecular pathway that allows the cell to monitor and adjust internal heme levels, creating more when heme levels fall, and slowing it down when levels rise.

The circuit is a negative feedback loop, with Rev-erbα as its central component, explains Lazar. "Rev-erbα is a thermostat for heme." When heme levels are high, Rev-erbα is activated, reducing heme, which leads the cell back towards a normal state. On the other hand, when heme levels are low, Rev-erbα activity is low, and this permits the cell to make more heme, again leading back toward a normal state. Maintaining this stasis allows energy metabolism to occur but avoids harm to the cell due to excessive levels of heme.

Understanding the control of heme levels is likely to be relevant to several diseases. For example, obesity is a condition where fat tissue builds up due to low energy expenditure relative to energy
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. FDA Updates Prescription Guidelines for Blood Thinner
2. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
3. Good Clinical Practice Journal Awards: Winners Announced
4. Researchers Find Better Way to Deliver Blood Thinner
5. ComPsych(R) Corp. Announces Health at Work(SM) Award Winners: Sprint, Erie Insurance, City of Naperville and Green Hills Public Library
6. Medifast Announces Winners of Mother-Daughter Challenge
7. SAMHSA Announces First Science and Service Award Winners
8. Family Dinners Shape Healthier Eating Habits
9. Vida Health Communications, Inc. to Be Honored as Tibbetts Award Winner
10. IMA South American Extravaganza Dinner to Honor Coachella Valley Doctor
11. No Clear Winner in Diabetes Treatment Trial
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inner workings of molecular thermostat point to pathways to fight diabetes, obesity
(Date:9/19/2014)... Capital Region Periodontics and Dental Implants, led ... the latest addition to their treatment options for ... dental implants. Often referred to as the “gentle ... factor normally associated with traditional gum surgery. No ... this procedure a very attractive oral surgery alternative ...
(Date:9/19/2014)... wonder material graphene has been used to detect molecules ... , The biosensor has been shown to be more ... in use, and was able to provide results in ... a rapid, point-of-care diagnostic tool for patients. , The ... Publishing,s journal 2D Materials . , To develop ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 ... a traditional Scandinavian style of eating, is ... Much like Diet Doc’s medical weight ... cooking and eating good food which leads ... focuses on teaching patients to understand how ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Activz Whole-Food ... Greens Smoothie product, a new whole-food produce powder ... in Baltimore, MD. Activz Greens Smoothie is ... in one convenient – and absolutely delicious —Greens Smoothie. ... in Baltimore, MD. , The new ...
(Date:9/19/2014)... QUT Centre for Accident Research & Road Safety - ... Safety in Transport Conference (OSIT) which is being held ... Ross Blackman, a CARRS-Q road safety researcher, said speed ... speed limits and related traffic controls remained in place ... wolf. If people are asked to slow down at ...
Breaking Medicine News(10 mins):Health News:Albany, NY Periodontist Reed Ference, DMD, Calms Fears of Patients with Gum Disease by Offering LANAP®, An Advanced, Less Invasive Treatment Solution 2Health News:Albany, NY Periodontist Reed Ference, DMD, Calms Fears of Patients with Gum Disease by Offering LANAP®, An Advanced, Less Invasive Treatment Solution 3Health News:Graphene sensor tracks down cancer biomarkers 2Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 2Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 3Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 4Health News:New Activz Greens Smoothie with 8 Organic Superfoods & More Launched at Natural Products Expo East 2Health News:New Activz Greens Smoothie with 8 Organic Superfoods & More Launched at Natural Products Expo East 3Health News:Don't cry wolf: Drivers fed up with slowing down at inactive roadwork sites 2
... new bladder cancer therapy show promising interim results. Lead ... drug Urocidin follows thirty years of his research in ... results of the trial," says Dr. Morales, professor emeritus ... director of the Queen,s University Centre for Applied Urological ...
... crashes each year. As a result, most states have put laws ... cell phones and PDAs while driving. But a new study led ... distracted driving and the laws being passed to address the problem. ... Journal of Preventive Medicine , is the first comprehensive collection and ...
... improve their outcomes if they walk briskly for at least ... recent study in Cancer Research , a journal of ... that men who walk briskly after their diagnosis may delay ... Erin Richman, Sc.D., a research associate at the University of ...
... MA May 24, 2010 CardioCareLive, the world,s ... Johns Hopkins University School of Medicine, today announced ... to be held over two days on Tuesday ... of interest to cardiovascular care and internal medicine ...
... 24, 2011 The latest episode in the ... Global Challenges/Chemistry Solutions ," focuses on new blood ... infected with an antibiotic-resistant bacterium that,s become a ... "superbug" is called methicillin-resistant Staphylococcus aureus, or simply ...
... , TUESDAY, May 24 (HealthDay News) -- Rain-making bacteria ... particles play in the Earth,s precipitation cycle, new research ... at the general meeting of the American Society for ... within the center of hailstones, suggesting that airborne microorganisms ...
Cached Medicine News:Health News:New made-in-Canada therapy for bladder cancer shows promising results 2Health News:Temple-led study finds widening gap between distracted driving and legislation 2Health News:Brisk walking could improve prostate cancer outcomes 2Health News:CME on atrial fibrillation, interventional cardiology and lipids online at CardioCareLive 2Health News:CME on atrial fibrillation, interventional cardiology and lipids online at CardioCareLive 3Health News:New American Chemical Society podcast: Fast test to diagnose MRSA infections 2Health News:Airborne Germs May Spur Rain, Snow, Hail 2
(Date:9/18/2014)... -- Research and Markets  has announced the addition ... Separation Columns Market" report to their offering. ... two enantiomers of the same compound with different affinities ... thus possessing different elution times. Chiral stationary phases are ... The chiral separation chromatography columns market is growing at ...
(Date:9/18/2014)... Texas , Sept. 18, 2014  Casen Buswell has ... and muscles to harden.  His case is one of only ... the world.  The only hospital in the United ... the world, offering treatment with the dual wave-length laser, is ... San Antonio . Using a laser available in ...
(Date:9/18/2014)... YORK , Sept. 18, 2014 This BCC Research ... share of major players, market growth and size, and opportunities ... trends and revenue through 2018. Patent analysis in the report ... as the U.S., Europe and ... to: - Define and discuss the global medical device technologies ...
Breaking Medicine Technology:Micro Market Monitor: Global Chiral Separation Columns Market 2Methodist Children's Hospital In San Antonio, TX Only Hospital In The U.S. Treating Rare Vascular Condition With Dual Wave-Length Laser 2Medical Devices: Technologies and Global Markets 2Medical Devices: Technologies and Global Markets 3Medical Devices: Technologies and Global Markets 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: