Navigation Links
Inner Workings of Gene Tied to Breast, Ovarian Cancer Revealed
Date:8/23/2010

o bump off those cells so they can't divide and behave badly."

Under normal circumstances, the BRCA gene would automatically correct those problems.

"But if you have certain mutations in the BRCA gene, then one of the mechanisms of repair - the BRCA gene - is not functioning properly, so that cell is allowed to proliferate and grow out of control," Smith said.

Over the course of several, often frustrating years, these scientists were able to purify the protein, which consists of 3,418 amino acids, to reveal some of its inner workings.

As it turns out, BRCA2 binds with another protein, RAD51, in a specific way to make sure that any breaks in the DNA get fixed correctly.

"It's a basic science discovery but it has many implications," said Stephen Kowalczykowski, senior author of the paper appearing in Nature and distinguished professor of microbiology and molecular and cellular biology at the University of California, Davis. "One would be that since we now know how the protein works, we can try to screen for therapeutic agents that could mitigate some of these problems."

"This illuminates a function of BRCA2 that's going to give new ideas to people who are involved in translational [lab-to-bedside] work," added Dr. Priscilla A. Furth, a professor of oncology and medicine at Lombardi Cancer Center of Georgetown University in Washington, D.C. "This is good, solid, basic science that is going to put us on a firm ground as we now look at why we get cancers from the loss of BRCA2."

"The more we can understand where the defect is the more we can try to correct it. RAD51 could be a molecule that we could target to make DNA repair actually effective in BRCA patients," Smith added. "That's the import of this work. It's not going to help us right now but we're moving more and more towards targeted therapy, designing treatments that target specific molecular abnormalities."

More information

There's more on
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Experts Support FDA Panels Backing of New Blood Thinner
2. Health Literacy Innovations Announces 1st Annual Health Literacy Innovator Award — Anonymous Donor Offers Prize Money To Winners
3. SNMs Technologist Section announces award winners
4. Intent.com Launches 30 Days of Intentions and Announces Winners of 2010 Intent Web Awards
5. High School Students Well-Schooled In Diversity: Teen Winners of Book Writing Contest Earn College Scholarships and Have Entries Published
6. 2010 OTC National Advertising Award Winners Announced
7. Judges Select Winner of the Ban Asbestos Now Video Search
8. IADR and GSK Consumer Healthcare announce winners of 2010 Innovation in Oral Care Awards
9. NIDA announces 2010 Addiction Science Award winners at Intel ISEF
10. MovieHatch.com Offers Fame on Massive Times Square Billboard; New Contest Puts Winner's Face in Lights in Heart of Broadway
11. Vietnamese Student Named UMass Boston JFK Award Winner
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inner Workings of Gene Tied to Breast, Ovarian Cancer Revealed
(Date:7/28/2014)... Camp Soaring Eagle today announced it ... Cornville, AZ. The nonprofit organization, founded in July ... to attend medically supervised camps at no cost ... a variety of programs to Arizona families and ... illnesses including: Illness Specific Camping Weekends, Illness Specific ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 An estimated ... year from metastatic breast and prostate cancers – an ... cancer has spread to other parts of the body, ... researchers at Drexel University College of Medicine ... identified that inhibits metastatic progression by blocking tumor cells ...
(Date:7/28/2014)... A revised version of a surgical procedure to treat ... more than 90 percent of the time in patients ... the MGH Division of Plastic and Reconstructive Surgery report ... the non-endoscopic procedure all of whom had headaches ... symptom relief a year later. The team,s paper ...
(Date:7/28/2014)... Glutamine is the most abundant single amino ... conditionally essential during times when the body undergoes large ... Immune System Support. , Having a heavy work out ... with additional glutamine may be advantageous. Glutamine supplementation may ... digestion and immune system function. Stress on the body ...
(Date:7/28/2014)... (HealthDay News) --,The more chronic medical conditions people have ... be, a new study claims. Since nearly ... scientists at Johns Hopkins Bloomberg School of Public Health ... gains in life expectancy are slowing in the United ... diabetes, kidney disease and heart failure is now the ...
Breaking Medicine News(10 mins):Health News:Camp Soaring Eagle Announces New Camp Site 2Health News:Camp Soaring Eagle Announces New Camp Site 3Health News:Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells 2Health News:Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells 3Health News:Non-endoscopic migraine surgery provides significant symptom relief 2Health News:Betancourt Nutrition Introduces Glutamine Plus with Sustamine® L-Alanyl-L-Glutamine 2Health News:Betancourt Nutrition Introduces Glutamine Plus with Sustamine® L-Alanyl-L-Glutamine 3Health News:Chronic Medical Conditions Can Shorten Seniors' Lives: Study 2
... as the newest participants in the Hartford Doctoral Fellows ... by the John A. Hartford Foundation , administered by ... James Lubben , DSW, MPH. Each fellow receives ... his or her home institution, which enables the recipient to ...
... , FRIDAY, Oct. 28 (HealthDay News) -- ... improvement if they,re placed in a classroom with higher-achieving ... low-achievers, researchers say. The findings are important because ... to poor children, whose development of language skills may ...
... recently awarded $7.2 million for the competitive renewal of ... Cancer Center,s Daniel Sullivan, M.D., executive vice president and ... through September 2016. The SEP2C enrolls patients to ... across six member sites. Moffitt is the lead site ...
... shrinking population of trim Americans against an expanding population of ... "fat bans." These "fat policies" would be designed to ... the growth in Americans, waistlines and in the country,s healthcare ... the Land of the Free and the Home of ...
... takes advantage of ovarian cancer,s reliance on folate appears to ... effects, researchers say., The therapy uses the folate receptors on ... a substance attracted to the receptors with a chemotherapeutic agent ... Chief of the Section of Gynecologic Oncology at Georgia Health ...
... burn up to 120 calories in half an hour while wheeling ... as much as someone doing the same action in a motorized ... and as much as 258 calories while fencing in a 30-minute ... This is according to a review article written by Professor David ...
Cached Medicine News:Health News:Prestigious Hartford grants bolster awardees' social work research 2Health News:Prestigious Hartford grants bolster awardees' social work research 3Health News:Preschool Peers May Boost Language Skills in Kids 2Health News:Home of the free - land of the fat? 2Health News:Folate receptors may serve as a front door to ovarian cancer treatment 2Health News:UT study looks at manual wheelchair use, exercise and calorie burning 2
(Date:7/28/2014)... (NYSE: RMD ), an innovator and pioneer ... and other chronic respiratory conditions, has won a permanent ... medical device manufacturer APEX Medical Corp. (APEX), prohibiting sales ... 220 masks.  The judgment was entered by the Regional ... appealable, and applies throughout Germany.  The ...
(Date:7/28/2014)... , July 28, 2014  ANI Pharmaceuticals, Inc. (NASDAQ: ... plans to release its second quarter and year-to-date 2014 ... opening of the U.S. financial markets. The earnings press ... of the Company,s website, www.anipharmaceuticals.com . ... Officer, and Charlotte C. Arnold , Vice President ...
(Date:7/28/2014)... , July 28, 2014  ProteinSimple announced today ... the Simple Western. This new assay allows users to detect ... first time, Simple Western users can analyze proteins without ... Simple Western has changed protein analysis as we know ... Western blot protocols - no messy gels, no transfer ...
Breaking Medicine Technology:ResMed Receives Permanent Injunction against APEX in Germany, Continues Enforcement of Patents in Europe 2ANI Pharmaceuticals Schedules Conference Call for Second Quarter 2014 Financial Results 2ProteinSimple Says "Never Run a Gel Again!" 2
... VioQuest,Pharmaceuticals (OTC Bulletin Board: VQPH) today ... of Lenocta(TM) (sodium stibogluconate), a novel,protein tyrosine ... immune stimulant approved for the treatment of ... cancers. The open-label Phase IIa study is,designed ...
... CuraGen Corporation,(Nasdaq: CRGN ), a clinical-stage biopharmaceutical ... Exchange: TOPO) announced,today that updated preliminary clinical trial ... T-cell lymphomas, and new preclinical data,evaluating belinostat on ... 2007 American Society of Hematology (ASH) 49th Annual ...
Cached Medicine Technology:VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor 2VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor 3VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor 4CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting 2CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting 3CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting 4CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: